{"id":5449,"date":"2024-06-03T13:57:32","date_gmt":"2024-06-03T13:57:32","guid":{"rendered":"https:\/\/www.thinkph1.eu\/?page_id=5449"},"modified":"2026-01-28T10:39:52","modified_gmt":"2026-01-28T10:39:52","slug":"scopri-la-ph1","status":"publish","type":"page","link":"https:\/\/www.thinkph1.eu\/it\/scopri-la-ph1\/","title":{"rendered":"Informazioni sull\u2019iperossaluria primitiva di tipo 1 (PH1) | Think PH1\u2122"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"5449\" class=\"elementor elementor-5449 elementor-25\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ed2ef5 e-flex e-con-boxed e-con e-parent\" data-id=\"5ed2ef5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e826260 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"e826260\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PANORAMICA DELL\u2019IPEROSSALURIA PRIMITIVA DI TIPO 1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7956335 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7956335\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019iperossaluria primitiva di tipo 1 (PH1) \u00e8 una malattia metabolica ereditaria rara, progressiva, potenzialmente pericolosa per la vita e che spesso si presenta con nefrolitiasi.<sup>1\u20133<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64ae249 e-flex e-con-boxed e-con e-parent\" data-id=\"64ae249\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b558f28 e-flex e-con-boxed e-con e-child\" data-id=\"b558f28\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d80e7aa elementor-widget elementor-widget-heading\" data-id=\"d80e7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LA PH1 \u00c8 UNA MALATTIA METABOLICA EREDITARIA RARA, PROGRESSIVA E CON SVILUPPO DI NEFROLITIASI<sup>1\u20133<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c341bcb elementor-widget elementor-widget-text-editor\" data-id=\"c341bcb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019iperossaluria primitiva (PH) \u00e8 un gruppo di malattie metaboliche autosomiche recessive con sviluppo di nefrolitiasi, derivanti da difetti in diversi enzimi coinvolti nel metabolismo del gliossilato che portano a un eccesso di produzione di ossalato in sede epatica.<sup>2,3<\/sup> Vi sono 3 tipi di PH: PH1, PH2 e PH3, e ciascun tipo \u00e8 causato da un difetto in un enzima diverso.<sup>3<\/sup><\/p><p>La PH1 si presenta spesso con nefrolitiasi ed \u00e8 causata da mutazioni autosomiche recessive nel gene <em>AGXT<\/em>, che compromettono la funzione dell\u2019enzima specifico del fegato alanina:gliossilato aminotransferasi (AGT).<sup>1,3<\/sup> Normalmente l\u2019AGT catalizza il gliossilato, che viene prodotto da un altro enzima epatico, la glicolato ossidasi (GO).<sup>2,3<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4652fb5 elementor-widget elementor-widget-text-editor\" data-id=\"4652fb5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Ascolta il Dott. Moochhala discutere del legame tra consanguineit\u00e0 e rischio di PH1<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-adf6d37 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"adf6d37\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/dr-shabbir-moochhala-it.jpg&quot;,&quot;id&quot;:8750,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Dott. Moochhala video&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1143804039?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/dr-shabbir-moochhala-it.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Dott. Moochhala video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c31a0b elementor-widget elementor-widget-text-editor\" data-id=\"4c31a0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tQuando valuti i pazienti affetti da calcoli renali, tieni conto della consanguineit\u00e0? Scopri perch\u00e9 \u00e8 importante nella valutazione dei pazienti con calcoli renali di causa sconosciuta.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2380ba elementor-widget elementor-widget-n-accordion\" data-id=\"b2380ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1860\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1860\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Leggi la trascrizione completa qui <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"icon icon-up-arrow1\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"icon icon-down-arrow1\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1860\" class=\"elementor-element elementor-element-6e8fe7e e-con-full e-flex e-con e-child\" data-id=\"6e8fe7e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3856c7c elementor-widget elementor-widget-text-editor\" data-id=\"3856c7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dott. Moochhala: PH1 \u00e8 un\u2019abbreviazione. Sta per iperossaluria primitiva di tipo 1. Primitiva significa che \u00e8 una malattia genetica. Iperossaluria significa che c\u2019\u00e8 un eccesso di ossalato nelle urine. L\u2019ossalato \u00e8 un prodotto di scarto. E tipo 1 ci dice che \u00e8 un particolare enzima a presentare un difetto. Vi sono alcuni effetti nocivi associati alla sovrapproduzione di ossalato nell\u2019organismo. L\u2019ossalato si deposita per prima cosa nei reni con conseguente formazione di calcoli, ma portando anche alla calcificazione dei reni stessi.<\/p><p>Pu\u00f2 inoltre depositarsi in tutti i tessuti molli. Dunque anche nella pelle, negli occhi, nel cuore, nei muscoli e cos\u00ec via. E si deposita in modo permanente, con possibile riduzione della funzionalit\u00e0 di tali tessuti. Ecco perch\u00e9 si tratta di una malattia cos\u00ec pericolosa e progressiva che vorremmo trattare il pi\u00f9 presto possibile. Molto spesso l\u2019unico segno pu\u00f2 essere il fatto che il paziente ha calcoli renali da un certo periodo di tempo. \u00c8 una malattia molto rara e questo \u00e8 il motivo per cui \u00e8 cos\u00ec difficile diagnosticarla.<\/p><p>Ma noi usiamo indizi, come la storia familiare. Vediamo emergere alcuni modelli iniziali, uno dei quali \u00e8 la pi\u00f9 alta prevalenza della PH1 in pazienti da determinati contesti, tra cui anche Sud-Est Asiatico, Medio Oriente e Nord Africa. Il mio messaggio a tutti i medici che visitano pazienti per diagnosticare malattia rare \u00e8 pensare, se riscontrano calcoli renali: \u201cCos\u2019ha causato la loro comparsa\u201d? Credo che, come per qualunque altra malattia o altro sintomo, la cosa da chiedersi sarebbe: \u201cQual \u00e8 il motivo\u201d? Dovremmo fare lo stesso in presenza di nefrolitiasi. Dovremmo chiederci: \u201cIl paziente ha diversi calcoli renali da un certo periodo di tempo. Perch\u00e9\u201c?\u00a0\u201cAbbiamo pensato alle possibili cause\u201c? \u201cAbbiamo fatto accertamenti\u201c? \u201cLo abbiamo riferito a uno specialista in grado di eseguire un esame pi\u00f9 dettagliato\u201d? Perch\u00e9 \u00e8 cos\u00ec che riusciremo a pervenire a una diagnosi, non solo per le malattie comuni ma anche per quelle rare. Se pensa di trovarsi dinanzi a qualcosa di inconsueto, ad esempio un paziente che forse ha una certa compromissione renale, ma con una storia familiare fortemente indicativa di qualcos\u2019altro, o se vede una quantit\u00e0 insolita di nefrolitiasi in un paziente giovane, indirizzi quel paziente a un nefrologo. La diagnosi precoce per la PH1 \u00e8 assolutamente critica. Prima si inizia a stabilizzare la funzionalit\u00e0 dei reni del paziente, pi\u00f9 possibilit\u00e0 avremo di ridurre e perfino prevenire ulteriori calcoli renali. Deve perseverare. Se ritiene che ci sia qualcosa che non va, preferirei di gran lunga visitare il paziente senza riscontrare problemi anzich\u00e9 trascurare chi potenzialmente ha una malattia rara come la PH1 o un\u2019altra patologia che causa nefrolitiasi. Quindi il mio messaggio \u00e8: si deve perseverare.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fee24f6 e-flex e-con-boxed e-con e-parent\" data-id=\"fee24f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3946a00 e-con-full e-flex e-con e-child\" data-id=\"3946a00\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-873fbc6 elementor-widget elementor-widget-heading\" data-id=\"873fbc6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">UNA DIAGNOSI PRECOCE DI PH1 PU\u00d2 CONTRIBUIRE A MITIGARE IL DANNO RENALE<sup>2\u20136<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f3883e0 e-grid e-con-boxed e-con e-child\" data-id=\"f3883e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e7ec9e8 e-con-full e-flex e-con e-child\" data-id=\"e7ec9e8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b9e8c43 elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"b9e8c43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div 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translate(29.000000, 11.000000)\"><\/path><g><path d=\"M18.3 1.4c-.4-.4-.9-.5-1.5-.5-1.1.1-2 1.1-1.9 2.2v1.2h-.2H1.3C.6 4.3 0 4.9 0 5.6c0 .7.6 1.3 1.3 1.3h13.4l-.1.3c-.7 2.4-2.3 4.6-4.9 6.6-.9.7-1 2-.4 2.9.4.5 1 .8 1.6.8.5 0 .9-.2 1.3-.4 5-3.9 7.3-8.6 6.9-14.2-.1-.7-.4-1.2-.8-1.5z\" fill=\"#1F2756\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000) translate(10.000000, 0.000000)\"><\/path><path d=\"M12.1 16.9c-.4.3-.8.4-1.3.4-.6 0-1.2-.3-1.6-.8-.7-.9-.5-2.2.4-2.9 2.6-2 4.2-4.2 4.9-6.6l.1-.3H1.3C.6 6.7 0 6.1 0 5.4c0-.7.6-1.3 1.3-1.3h13.6L15 4v-.9C14.9 2 15.8 1 16.9.9c.5 0 1.1.1 1.5.5.3.3.6.8.6 1.4.4 5.6-1.8 10.2-6.9 14.1z\" fill=\"#062059\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000) translate(10.000000, 0.000000)\"><\/path><\/g><path d=\"M19 60H6.2l.1-.3c.6-2.6 2.3-5 5.1-7.2.9-.7 1-2 .4-2.9-.3-.4-.8-.7-1.4-.8h-.3c-.5 0-.9.2-1.3.4-5 3.9-7.3 8.6-6.9 14.2.1 1.1 1.1 2 2.2 1.9.5 0 1-.3 1.4-.7.4-.4.5-.9.5-1.5V62.5h13c.7 0 1.3-.6 1.3-1.3 0-.6-.6-1.2-1.3-1.2z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000)\"><\/path><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tLa PH1 \u00e8 il tipo pi\u00f9 comune e pi\u00f9 grave di PH<sup>1,3,7<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-041b21c elementor-widget elementor-widget-text-editor\" data-id=\"041b21c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Il 70%\u201380% dei casi di PH \u00e8 costituito da PH1. Nonostante ci\u00f2, la PH1 \u00e8 una malattia rara, responsabile secondo le stime di circa 1\u20133 casi per milione di abitanti, un tasso di incidenza pari a 1 caso ogni 120.000 nati vivi all\u2019anno in Europa con maggiore prevalenza nella regione di Medio Oriente e Nord Africa.<sup>1,3,7<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ccac162 e-con-full e-flex e-con e-child\" data-id=\"ccac162\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-87bac69 elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"87bac69\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"88\" height=\"88\" viewBox=\"0 0 88 88\"><g fill=\"none\" fill-rule=\"nonzero\"><path fill=\"#1E2656\" d=\"M23.362 54c-5.525 0-10.079-2.679-13.562-7.982a22.931 22.931 0 0 1-3.276-9.555c-.207-1.182-.306-2.375-.393-3.514L6 31.419v-.205c.11-3.45.459-7.451 2.577-11.139 3.702-6.312 9.27-9.349 16.576-9.056 2.543.014 5.034.715 7.207 2.028 3.647 2.343 5.547 5.922 5.634 10.64a10.146 10.146 0 0 1-.906 4.544 1.68 1.68 0 0 1-2.89.27 1.655 1.655 0 0 1-.157-1.658c.443-.97.652-2.028.612-3.091-.077-3.59-1.42-6.182-4.117-7.906a10.647 10.647 0 0 0-5.514-1.508c-5.61-.482-10.96 2.442-13.551 7.408-1.584 2.7-1.999 5.704-2.13 9.478 0 .489.088.977.12 1.454.099 1.15.186 2.234.339 3.308a19.93 19.93 0 0 0 2.806 8.22c2.85 4.339 6.377 6.508 10.767 6.508h.874a7.85 7.85 0 0 0 5.83-2.755c1.748-2.071 2.589-5.238-.283-7.906a1.664 1.664 0 0 1 .605-2.916 1.689 1.689 0 0 1 1.688.486A8.651 8.651 0 0 1 35.013 44a9.562 9.562 0 0 1-2.347 6.02 11.145 11.145 0 0 1-8.201 3.947L23.362 54z\"><\/path><path fill=\"#2098D5\" d=\"M37.468 35.62c-2.727-3.29-6.761-5.023-10.007-6.153a12.252 12.252 0 0 0-1.42-2.403 6.616 6.616 0 0 0 1.533-1.865l1.499-2.5c.162-.255.21-.563.134-.853a1.101 1.101 0 0 0-.54-.683 1.153 1.153 0 0 0-.878-.127c-.298.077-.55.27-.7.532l-1.532 2.49a5.544 5.544 0 0 1-.834 1.207 6.504 6.504 0 0 1-1.127-2.358 1.13 1.13 0 0 0-.763-.838c-.39-.126-.82-.04-1.127.225-.307.266-.446.67-.363 1.062a11.553 11.553 0 0 0 2.32 4.388c.65.781 1.206 1.631 1.657 2.534.08.175.147.355.203.538.143.432.212.884.203 1.338a4.302 4.302 0 0 1-.63 2.106 8.883 8.883 0 0 1-2.683 2.732l-4.417-1.997-1.51-.416a1.193 1.193 0 0 0-1.134.282 1.12 1.12 0 0 0-.315 1.097c.103.394.415.705.818.815l1.34.373 2.784 1.25c-.906.427-1.854.765-2.828 1.01a1.126 1.126 0 0 0-.708.491c-.159.25-.208.55-.138.836.123.506.594.858 1.127.844.094.011.188.011.282 0a19.037 19.037 0 0 0 5.127-2.194 1.13 1.13 0 0 0 .665-.416 11.331 11.331 0 0 0 3.572-3.599 6.47 6.47 0 0 0 .846-2.281 16.935 16.935 0 0 1 6.952 4.552c3.313 3.993 3.088 9.763 2.322 13.899-.372 1.996-.913 4.015-1.431 5.978a54.344 54.344 0 0 0-1.95 9.742 27.935 27.935 0 0 0 .642 8.468c.165.738.836 1.264 1.612 1.262.123.016.248.016.372 0 .437-.086.82-.342 1.06-.708.24-.366.317-.811.213-1.234a24.644 24.644 0 0 1-.563-7.547c.34-3.108.961-6.18 1.859-9.182.53-2.018 1.127-4.091 1.476-6.198.868-4.804 1.07-11.562-3.02-16.498z\"><\/path><path fill=\"#1E2656\" d=\"M64.674 54c5.524 0 10.077-2.679 13.56-7.982a22.934 22.934 0 0 0 3.275-9.555c.174-1.182.273-2.375.36-3.514l.131-1.53v-.205c-.12-3.45-.426-7.451-2.587-11.139-3.701-6.312-9.27-9.349-16.573-9.056a14.076 14.076 0 0 0-7.206 2.028c-3.646 2.343-5.546 5.922-5.633 10.64a10.15 10.15 0 0 0 1.004 4.544 1.68 1.68 0 0 0 2.222.819 1.66 1.66 0 0 0 .824-2.207 6.815 6.815 0 0 1-.611-3.091c.076-3.59 1.42-6.182 4.116-7.906a10.643 10.643 0 0 1 5.459-1.508c5.609-.482 10.957 2.442 13.548 7.408 1.583 2.7 1.998 5.737 2.184 9.478 0 .489-.088.977-.12 1.454-.099 1.15-.186 2.234-.339 3.308a19.932 19.932 0 0 1-2.806 8.22c-2.85 4.339-6.375 6.508-10.764 6.508h-.874a7.848 7.848 0 0 1-5.83-2.755c-1.746-2.071-2.587-5.238.284-7.906a1.662 1.662 0 0 0-.016-2.267 1.69 1.69 0 0 0-2.276-.163A8.652 8.652 0 0 0 53.08 44a9.562 9.562 0 0 0 2.292 6.02 11.142 11.142 0 0 0 8.2 3.947l1.102.033z\"><\/path><path fill=\"#2098D5\" d=\"M50.532 35.62c2.727-3.29 6.761-5.023 10.006-6.153.38-.85.856-1.656 1.42-2.403a6.616 6.616 0 0 1-1.532-1.865l-1.465-2.5a1.072 1.072 0 0 1-.135-.853c.077-.29.272-.537.54-.683.263-.158.58-.203.879-.127.298.077.55.27.699.532l1.499 2.49c.222.437.503.842.834 1.207a6.504 6.504 0 0 0 1.126-2.358c.128-.606.736-.997 1.358-.872a1.12 1.12 0 0 1 .896 1.321 11.553 11.553 0 0 1-2.321 4.388 13.221 13.221 0 0 0-1.657 2.534 4.41 4.41 0 0 0-.202.538 4.024 4.024 0 0 0-.203 1.338c.023.743.24 1.468.63 2.106a8.883 8.883 0 0 0 2.683 2.732l4.417-1.997 1.51-.416c.622-.17 1.268.184 1.442.79a1.136 1.136 0 0 1-.811 1.404l-1.34.373-2.784 1.25c.906.427 1.853.765 2.828 1.01.294.064.549.242.708.491.159.25.208.55.137.836a1.122 1.122 0 0 1-1.127.844c-.093.011-.188.011-.281 0a19.036 19.036 0 0 1-5.128-2.194 1.13 1.13 0 0 1-.664-.416 11.331 11.331 0 0 1-3.573-3.599 6.47 6.47 0 0 1-.845-2.281 16.935 16.935 0 0 0-6.952 4.552c-3.313 3.993-3.088 9.763-2.322 13.899.372 1.996.913 4.015 1.431 5.978a54.344 54.344 0 0 1 1.95 9.742 27.936 27.936 0 0 1-.642 8.468c-.165.738-.836 1.264-1.612 1.262a1.435 1.435 0 0 1-.372 0 1.646 1.646 0 0 1-1.06-.708 1.566 1.566 0 0 1-.213-1.234c.575-2.474.765-5.018.563-7.547a51.605 51.605 0 0 0-1.859-9.182c-.53-2.018-1.127-4.091-1.476-6.198-.868-4.804-1.07-11.562 3.02-16.498z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tLa PH1 pu\u00f2 provocare danni irreparabili ai reni<sup>1,3<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41b774d elementor-widget elementor-widget-text-editor\" data-id=\"41b774d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tUno degli aspetti pi\u00f9 devastanti della PH1 \u00e8 il progressivo declino della funzionalit\u00e0 renale, culminante nella nefropatia in stadio terminale (ESRD).<sup>1,3,6<\/sup> Inoltre, esiste il rischio potenziale di ossalosi sistemica.<sup>3,8<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d68c75b e-con-full e-flex e-con e-child\" data-id=\"d68c75b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb0223d elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"cb0223d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" height=\"88\" viewBox=\"0 0 88 88\" width=\"88\"><g fill=\"none\" fill-rule=\"evenodd\"><g fill-rule=\"nonzero\"><g><g><g><path d=\"M1.2 47.1c0 .3-.7 5.5-.2 13.4.1 2.2 1.9 3.9 4.1 3.9h17.5c2.2 0 4-1.7 4.1-3.9.5-7.4-.2-13.3-.2-13.4-.3-2.6-.9-5.4-1.9-8.5-.9-2.9-1.4-6.3.1-9 .9-1.8 1.8-4 1.8-6.2.3-9.8-5.8-12.4-8-13.1V8.5h.5c.5 0 1-.4 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2.7-3.7 5.2-.1.5.3 1 .8 1.1h.1c.5 0 .9-.4 1-.8.2-1.7 1.1-3.1 2.5-3.6.5-.2.7-.7.6-1.2-.3-.6-.8-.9-1.3-.7z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(22.000000, 0.000000)\"><\/path><\/g><g><path d=\"M1.2 37.5c0 .2-.6 4.4-.2 10.8.1 1.7 1.6 3.1 3.3 3.1h14c1.7 0 3.2-1.4 3.3-3.1.4-5.9-.2-10.7-.2-10.8-.2-2.1-.7-4.3-1.5-6.8-.8-2.3-1.1-5.1.1-7.2.7-1.4 1.4-3.2 1.5-5 .2-7.8-4.6-10-6.4-10.5V6.6h.4c.4 0 .8-.3.8-.8V2c0-.9-.8-1.7-1.7-1.7H8.2c-.9 0-1.7.8-1.7 1.7v3.8c0 .4.3.8.8.8h.4V8c-1.8.5-6.7 2.7-6.4 10.5 0 1.3.5 3.1 1.5 5 .7 1.3 1.2 3.5.1 7.2-.9 2.4-1.4 4.7-1.7 6.8zm18.9 1.6c.2 2.8.3 5.8 0 9.1-.1.9-.8 1.6-1.7 1.6h-14c-.9 0-1.7-.7-1.7-1.6-.2-3.3-.2-6.3.1-9.1h17.3zM8 2c0-.1.1-.1.1-.1h6.4c.1 0 .1.1.1.1v3H7.9V2H8zm.6 7.3c.4 0 .7-.4.7-.8v-2h4.2v2c0 .4.3.7.7.8.2 0 6 .9 5.8 9H2.8c-.2-8.1 5.5-9 5.8-9zM4.1 22.7c-.8-1.4-1-2.3-1.1-2.9h16.7c-.1.5-.3 1.4-1.1 2.9s-1.5 4.3-.2 8.4c.9 2.7 1.3 4.7 1.4 6.4h-17c.3-2.2.8-4.4 1.5-6.5.9-2.7 1.2-5.8-.2-8.3z\" fill=\"#062059\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(49.000000, 10.000000)\"><\/path><path d=\"M12 23.1c-.3-.5-1-.5-1.3 0-.6.9-3.3 5.6-3.3 7.4 0 2.2 1.8 4 4 4s4-1.8 4-4c-.1-1.8-2.8-6.4-3.4-7.4zM13.7 48.2h2.4c1.3 0 2.3-1 2.3-2.3v-1.3c0-.4-.3-.8-.8-.8-.4 0-.8.3-.8.8v1.3c0 .4-.3.8-.8.8h-2.4c-.4 0-.8.3-.8.8s.5.7.9.7zM8.2 11.6c-1.6.6-2.7 2.2-3 4.1-.1.4.3.8.7.9H6c.4 0 .7-.3.8-.7.2-1.4.9-2.5 2-2.9.4-.2.6-.6.4-1-.1-.4-.6-.6-1-.4z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(49.000000, 10.000000)\"><\/path><\/g><g><path d=\"M1.1 37.5c0 .2-.6 4.4-.2 10.8.1 1.7 1.5 3.1 3.3 3.1h14c1.7 0 3.2-1.4 3.3-3.1.4-5.9-.2-10.7-.2-10.8-.2-2.1-.7-4.3-1.5-6.8-.8-2.3-1.1-5.1.1-7.2.7-1.4 1.4-3.2 1.5-5 .2-7.8-4.6-10-6.4-10.5V6.6h.4c.4 0 .8-.3.8-.8V2c0-.9-.8-1.7-1.7-1.7H8c-.9 0-1.7.8-1.7 1.7v3.8c0 .4.3.8.8.8h.4V8c-1.8.5-6.7 2.7-6.4 10.5 0 1.3.5 3.1 1.5 5 .7 1.3 1.2 3.5.1 7.2-.9 2.4-1.4 4.7-1.6 6.8zm18.8 1.6c.2 2.8.3 5.8 0 9.1-.1.9-.8 1.6-1.7 1.6h-14c-.9 0-1.7-.7-1.7-1.6-.2-3.3-.2-6.3.1-9.1h17.3zM7.8 2c0-.1.1-.1.1-.1h6.4c.1 0 .1.1.1.1v3H7.7V2h.1zm.6 7.3c.4 0 .7-.4.7-.8v-2h4.2v2c0 .4.3.7.7.8.2 0 6 .9 5.8 9H2.6c-.2-8.1 5.5-9 5.8-9zM3.9 22.7c-.8-1.4-1-2.3-1.1-2.9h16.7c-.1.5-.3 1.4-1.1 2.9s-1.5 4.3-.2 8.4c.9 2.7 1.3 4.7 1.4 6.4h-17c.3-2.2.8-4.4 1.5-6.5.9-2.7 1.2-5.8-.2-8.3z\" fill=\"#062059\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(0.000000, 10.000000)\"><\/path><path d=\"M11.8 23.1c-.3-.5-1-.5-1.3 0-.6.9-3.3 5.6-3.3 7.4 0 2.2 1.8 4 4 4s4-1.8 4-4c-.1-1.8-2.8-6.4-3.4-7.4zM13.5 48.2H16c1.3 0 2.3-1 2.3-2.3v-1.3c0-.4-.3-.8-.8-.8-.4 0-.8.3-.8.8v1.3c0 .4-.3.8-.8.8h-2.4c-.4 0-.8.3-.8.8s.4.7.8.7zM8 11.6c-1.6.6-2.7 2.2-3 4.1-.1.4.3.8.7.9h.1c.4 0 .7-.3.8-.7.2-1.4.9-2.5 2-2.9.4-.1.6-.6.4-1-.1-.4-.6-.6-1-.4z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(0.000000, 10.000000)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tLa diagnosi e l\u2019intervento precoci sono fondamentali per mitigare i danni<sup>2\u20136<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf0d0c3 elementor-widget elementor-widget-text-editor\" data-id=\"bf0d0c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLa gestione della patologia pu\u00f2 alleviare il danno riducendo la formazione di calcoli e la deposizione di cristalli di ossalato di calcio nei reni; ci\u00f2 sottolinea l\u2019importanza della diagnosi e dell\u2019intervento precoci.<sup>3,7,8<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-834924a e-flex e-con-boxed e-con e-parent\" data-id=\"834924a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d45841f elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d45841f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/it\/riconosci-i-segni\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Riconosci i segni<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-81dc0fb elementor-widget elementor-widget-heading\" data-id=\"81dc0fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LA PH1 \u00c8 PROGRESSIVA E SISTEMICA<sup>2,9<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb170e3 elementor-widget elementor-widget-heading\" data-id=\"fb170e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Scopri come la PH1 pu\u00f2 essere pericolosa per la vita<sup>2<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8ed625 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"d8ed625\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/PH1-ITA-00008_PH1-MOD-ita.jpg&quot;,&quot;id&quot;:5776,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Miniatura video sul meccanismo della PH1&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1151008795?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1&amp;h=27591abf1e#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00008_PH1-MOD-ita.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Miniatura video sul meccanismo della PH1\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a05300 elementor-widget elementor-widget-text-editor\" data-id=\"4a05300\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La PH1 porta al progressivo declino della funzionalit\u00e0 renale.<sup>2<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-18b58b1 e-flex e-con-boxed e-con e-parent\" data-id=\"18b58b1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-490699c elementor-widget elementor-widget-heading\" data-id=\"490699c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u2019ECCESSO DI OSSALATO PU\u00d2 DANNEGGIARE I RENI<sup>9<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9e086d elementor-widget elementor-widget-text-editor\" data-id=\"e9e086d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019eccesso di produzione di ossalato in sede epatica pu\u00f2 portare a infiammazione e al progressivo declino della funzionalit\u00e0 renale in seguito alla formazione di cristalli di ossalato di calcio.<sup>8,9<\/sup> Il continuo eccesso di produzione di ossalato pu\u00f2 sfociare in danni irreversibili ai reni e ad altri organi.<sup>8,9<\/sup><\/p>\n<p>La PH1 avanza a velocit\u00e0 variabile, progredendo fino alla ESRD.<sup>2<\/sup> Quando i reni non sono in grado di espellere efficacemente l\u2019ossalato a causa della tossicit\u00e0 derivante dalla deposizione di cristalli di ossalato di calcio, pu\u00f2 verificarsi ossalosi sistemica, la diffusa deposizione di ossalato di calcio nei tessuti.<sup>9<\/sup> Le complicanze dell\u2019ossalosi sistemica possono essere fatali.<sup>2<\/sup><\/p>\n<p>In alcuni casi, la funzionalit\u00e0 renale pu\u00f2 peggiorare dopo un singolo episodio di disidratazione dovuto a malattia acuta o attivit\u00e0 fisica intensa.<sup>10\u201313<\/sup> Ci\u00f2 pu\u00f2 verificarsi anche in pazienti con malattia precedentemente stabile.<sup>9,11<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6c8909 e-flex e-con-boxed e-con e-parent\" data-id=\"c6c8909\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-03585b9 e-flex e-con-boxed e-con e-child\" data-id=\"03585b9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b15ab3d elementor-widget elementor-widget-heading\" data-id=\"b15ab3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">COSA CAUSA L\u2019ECCESSO DI PRODUZIONE DI OSSALATO NELLA PH1?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1da21d elementor-widget elementor-widget-heading\" data-id=\"c1da21d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Incapacit\u00e0 dell\u2019AGT di catalizzare il gliossilato prodotto dalla GO<sup>2<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ba4b4cd e-grid e-con-boxed e-con e-child\" data-id=\"ba4b4cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef80976 elementor-widget elementor-widget-text-editor\" data-id=\"ef80976\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La PH1 \u00e8 una malattia genetica causata da mutazioni nel gene <em>AGXT<\/em> che rende disfunzionale l\u2019enzima epatico AGT.<sup class=\"sup\">3<\/sup><\/p><p class=\"mb-70 mob-mb-40\">Normalmente l\u2019AGT catalizza il gliossilato, che viene prodotto da un altro enzima epatico chiamato GO.<sup class=\"sup\">2,3<\/sup> Nella PH1, un difetto nell\u2019AGT comporta la conversione del gliossilato in ossalato.<sup class=\"sup\">2<\/sup> L\u2019ossalato non pu\u00f2 essere metabolizzato e a livelli normali viene generalmente escreto dai reni.<sup class=\"sup\">3<\/sup> Se prodotto in eccesso, come nella PH1, l\u2019ossalato pu\u00f2 provocare danni progressivi e irreversibili.<sup class=\"sup\">2<\/sup> L\u2019ossalato si combina con il calcio, generando cristalli di ossalato di calcio.<sup class=\"sup\">2<\/sup> Questi cristalli si depositano nei tessuti renali, dove possono aggregarsi formando calcoli renali o causare nefrocalcinosi.<sup class=\"sup\">2,9<\/sup> Con il progressivo accumulo di ossalato di calcio si ha una compromissione dell\u2019escrezione renale e i cristalli si depositano in tutto l\u2019organismo.<sup>9<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-545ff66 e-flex e-con-boxed e-con e-child\" data-id=\"545ff66\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-579544e elementor-widget elementor-widget-heading\" data-id=\"579544e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Scarica una panoramica della PH1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70a977f e-con-full e-flex e-con e-child\" data-id=\"70a977f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-acfcc44 e-con-full e-flex e-con e-child\" data-id=\"acfcc44\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f62fbc elementor-widget elementor-widget-image\" data-id=\"4f62fbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"849\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00092-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-negli-adulti-1.jpg\" class=\"attachment-full size-full wp-image-6767\" alt=\"PH1-ITA-00092-Quando-la-nefrolitiasi-indica-qualcosa-di-pi\u00f9-serio-negli-adulti\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00092-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-negli-adulti-1.jpg 600w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00092-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-negli-adulti-1-212x300.jpg 212w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52e0210 elementor-widget elementor-widget-heading\" data-id=\"52e0210\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">ADULTO<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1af67c3 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"1af67c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/downloads\/it\/PH1-ITA-00092-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-negli-adulti.pdf\" target=\"_blank\" download=\"PH1-ITA-00092-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-negli-adulti\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"15\" viewBox=\"0 0 16 15\"><path fill=\"#D0191F\" fill-rule=\"evenodd\" d=\"M14.28 7.58a.5.5 0 0 1 1 0v4.825c0 .643-.263 1.227-.685 1.65a2.332 2.332 0 0 1-1.65.685H2.335a2.328 2.328 0 0 1-1.65-.685A2.324 2.324 0 0 1 0 12.405V7.58a.5.5 0 0 1 1 0v4.825a1.335 1.335 0 0 0 1.334 1.334h10.611a1.338 1.338 0 0 0 1.334-1.334V7.58zm-9.958-.854a.5.5 0 0 1 .707-.707l2.111 2.11V.5a.5.5 0 0 1 1 0v7.63l2.11-2.11a.5.5 0 0 1 .707.707l-2.96 2.96a.453.453 0 0 1-.032.03l-.018.015-.004.003-.008.006-.008.006-.005.004-.004.002-.006.005-.004.003-.006.003-.008.005a.508.508 0 0 1-.508 0l-.009-.005-.004-.003-.004-.003-.008-.005-.002-.002-.006-.004-.008-.006h-.002l-.005-.006-.004-.003a.173.173 0 0 1-.02-.014c-.012-.01-.02-.02-.03-.031l-2.962-2.96z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Scarica<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a70326c e-con-full e-flex e-con e-child\" data-id=\"a70326c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fd1fdd3 elementor-widget elementor-widget-image\" data-id=\"fd1fdd3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"600\" height=\"849\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00093-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-nei-bambini-1.jpg\" class=\"attachment-full size-full wp-image-6768\" alt=\"PH1-ITA-00093-Quando-la-nefrolitiasi-indica-qualcosa-di-pi\u00f9-serio-nei-bambini\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00093-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-nei-bambini-1.jpg 600w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ITA-00093-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-nei-bambini-1-212x300.jpg 212w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01fd9d8 elementor-widget elementor-widget-heading\" data-id=\"01fd9d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">BAMBINO<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0f4ef7 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"e0f4ef7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/downloads\/it\/PH1-ITA-00093-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-nei-bambini.pdf\" target=\"_blank\" download=\"PH1-ITA-00093-Quando-la-nefrolitiasi-indica-qualcosa-di-piu-serio-nei-bambini\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"15\" viewBox=\"0 0 16 15\"><path fill=\"#D0191F\" fill-rule=\"evenodd\" d=\"M14.28 7.58a.5.5 0 0 1 1 0v4.825c0 .643-.263 1.227-.685 1.65a2.332 2.332 0 0 1-1.65.685H2.335a2.328 2.328 0 0 1-1.65-.685A2.324 2.324 0 0 1 0 12.405V7.58a.5.5 0 0 1 1 0v4.825a1.335 1.335 0 0 0 1.334 1.334h10.611a1.338 1.338 0 0 0 1.334-1.334V7.58zm-9.958-.854a.5.5 0 0 1 .707-.707l2.111 2.11V.5a.5.5 0 0 1 1 0v7.63l2.11-2.11a.5.5 0 0 1 .707.707l-2.96 2.96a.453.453 0 0 1-.032.03l-.018.015-.004.003-.008.006-.008.006-.005.004-.004.002-.006.005-.004.003-.006.003-.008.005a.508.508 0 0 1-.508 0l-.009-.005-.004-.003-.004-.003-.008-.005-.002-.002-.006-.004-.008-.006h-.002l-.005-.006-.004-.003a.173.173 0 0 1-.02-.014c-.012-.01-.02-.02-.03-.031l-2.962-2.96z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Scarica<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-06906e6 e-flex e-con-boxed e-con e-parent\" data-id=\"06906e6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-88643fd e-con-full e-flex e-con e-child\" data-id=\"88643fd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5196e77 elementor-widget elementor-widget-image\" data-id=\"5196e77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"247\" height=\"249\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle.png\" class=\"attachment-large size-large wp-image-5522\" alt=\"Kim Hollander - Direttore esecutivo - Fondazione per l\u2019ossalosi e l\u2019iperossaluria (OHF)\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle.png 247w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle-150x150.png 150w\" sizes=\"(max-width: 247px) 100vw, 247px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-11e20b3 e-con-full e-flex e-con e-child\" data-id=\"11e20b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22d351c elementor-widget elementor-widget-text-editor\" data-id=\"22d351c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u201cData la natura di questa malattia, \u00e8 possibile che la PH1 non venga diagnosticata per molti anni. I primi sintomi negli adulti, come la nefrolitiasi, sono spesso attribuiti ad altre condizioni molto pi\u00f9 comuni. Dobbiamo aiutare i medici a riconoscere i sintomi pi\u00f9 velocemente, per arrestare la progressione prima che il paziente giunga all\u2019insufficienza renale in stadio terminale\u201d.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c2cfe8 elementor-widget elementor-widget-text-editor\" data-id=\"6c2cfe8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Kim Hollander<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a69df67 person-role elementor-widget elementor-widget-text-editor\" data-id=\"a69df67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDirettore esecutivo, <a style=\"color: #1f99d5;\" href=\"https:\/\/ohf.org\/\" rel=\"nofollow\" class=\"external\">Fondazione per l\u2019ossalosi e l\u2019iperossaluria (OHF)<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe7e8fc e-flex e-con-boxed e-con e-parent\" data-id=\"fe7e8fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-094ad73 elementor-hidden-tablet elementor-hidden-mobile elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"094ad73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc862c8 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"dc862c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/it\/riconosci-i-segni\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">VAI A <span>RICONOSCI I SEGNI<span style=\"background-color: var( --e-global-color-5a8cfc1 );color: var( --e-global-color-accent );font-size: 32px\"><\/span><\/span><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e996090 e-flex e-con-boxed e-con e-parent\" data-id=\"e996090\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4dda9423 e-con-full e-flex e-con e-child\" data-id=\"4dda9423\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27f870e6 elementor-widget elementor-widget-heading\" data-id=\"27f870e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Test dei pazienti per la PH1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33003895 elementor-widget elementor-widget-text-editor\" data-id=\"33003895\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Scopri come i test genetici svolgono un ruolo importante nella diagnosi della PH1.<sup>2,4<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61982d65 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"61982d65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/it\/test-per-la-ph1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Opzioni di test<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2525b1e4 e-con-full e-flex e-con e-child\" data-id=\"2525b1e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b4575f8 elementor-widget elementor-widget-heading\" data-id=\"5b4575f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ricevi aggiornamenti<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37f042f4 elementor-widget elementor-widget-text-editor\" data-id=\"37f042f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Iscriviti per ricevere informazioni da Alnylam sulla PH1.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f72a8f elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2f72a8f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Iscriviti<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ae63e4 e-flex e-con-boxed e-con e-parent\" data-id=\"1ae63e4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-478a2d1 elementor-widget elementor-widget-text-editor\" data-id=\"478a2d1\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"footer-refs\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Bibliografia: 1.<\/strong> Hoppe B. <em>Nat Rev Nephrol.<\/em> 2012;8(8):467\u2013475. <strong>2.<\/strong> Milliner DS, Harris PC, Sas DJ, <em>et al.<\/em> Primary hyperoxaluria type 1. GeneReviews<sup>\u00ae<\/sup> [<em>Internet<\/em>]. Aggiornato il 15 agosto 2024. Ultimo accesso: febbraio 2026. <a class=\"comment-text__link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/<\/a> <strong>3.<\/strong> Cochat P, Rumsby G. <em>N Engl J Med.<\/em> 2013;369(7):649\u2013658. <strong>4.<\/strong> Cochat P, Hulton SA, Acquaviva C, <em>et al. Nephrol Dial Transplant.<\/em> 2012;27(5):1729\u20131736. <strong>5.<\/strong> Ben-Shalom E, Frishberg Y. <em>Pediatr Nephrol.<\/em> 2015;30(10):1781\u20131791. <strong>6.<\/strong> Raju DL, Cantarovich M, Brisson ML, <em>et al. Am J Kidney Dis.<\/em> 2008;51(1):e1\u2013e5. <strong>7.<\/strong> Bhasin B, \u00dcrekli HM, Atta MG. <em>World J Nephrol.<\/em> 2015;4(2):235\u2013244. <strong>8.<\/strong> Hoppe B, Beck BB, Milliner DS. <em>Kidney Int.<\/em> 2009;75(12):1264\u20131271. <strong>9.<\/strong> Leumann E, Hoppe B. <em>J Am Soc Nephrol.<\/em> 2001;12(9):1986\u20131993. <strong>10.<\/strong> El-Reshaid K, Al-Bader D, Madda JP. <em>Saudi J Kidney Dis Transpl.<\/em> 2016;27(3):606\u2013609. <strong>11.<\/strong> Cochat P. <em>Kidney Int.<\/em> 1999;55(6):2533\u20132547. <strong>12.<\/strong> Harambat J, Fargue S, Bacchetta J, <em>et al. Int J Nephrol.<\/em> 2011;2011:864580. <strong>13.<\/strong> Tintillier M, Pochet JM, Cosyns JP, <em>et al. Clin Nephrol.<\/em> 2004;62(2):155\u2013157.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60902a3 elementor-widget elementor-widget-text-editor\" data-id=\"60902a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>PH1-ITA-00137 | Febbraio 2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Scopri di pi\u00f9 sull\u2019iperossaluria primitiva di tipo 1 (PH1), una rara malattia genetica progressiva che spesso si manifesta con calcoli renali e pu\u00f2 causare danni renali irreversibili.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-5449","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/pages\/5449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/comments?post=5449"}],"version-history":[{"count":132,"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/pages\/5449\/revisions"}],"predecessor-version":[{"id":8848,"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/pages\/5449\/revisions\/8848"}],"wp:attachment":[{"href":"https:\/\/www.thinkph1.eu\/it\/wp-json\/wp\/v2\/media?parent=5449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}