{"id":6884,"date":"2024-06-03T13:57:32","date_gmt":"2024-06-03T13:57:32","guid":{"rendered":"https:\/\/www.thinkph1.eu\/?page_id=6884"},"modified":"2026-02-02T14:08:40","modified_gmt":"2026-02-02T14:08:40","slug":"decouvrir-lhp1","status":"publish","type":"page","link":"https:\/\/www.thinkph1.eu\/fr\/decouvrir-lhp1\/","title":{"rendered":"\u00c0 propos de l\u2019hyperoxalurie primitive de type 1 (HP1) | Think PH1\u2122"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6884\" class=\"elementor elementor-6884 elementor-25\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ed2ef5 e-flex e-con-boxed e-con e-parent\" data-id=\"5ed2ef5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e826260 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"e826260\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u2019HYPEROXALURIE PRIMITIVE DE TYPE 1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7956335 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7956335\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019hyperoxalurie primitive de type 1 (HP1) est une maladie lithiasique m\u00e9tabolique h\u00e9r\u00e9ditaire, rare, progressive et potentiellement mortelle, qui se manifeste souvent par des calculs r\u00e9naux.<sup>1\u20133<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64ae249 e-flex e-con-boxed e-con e-parent\" data-id=\"64ae249\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b558f28 e-flex e-con-boxed e-con e-child\" data-id=\"b558f28\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d80e7aa elementor-widget elementor-widget-heading\" data-id=\"d80e7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u2019HP1 EST UNE MALADIE LITHIASIQUE H\u00c9R\u00c9DITAIRE, RARE ET PROGRESSIVE<sup>1\u20133<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c341bcb elementor-widget elementor-widget-text-editor\" data-id=\"c341bcb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019hyperoxalurie primitive (HP) est un groupe de maladies lithiasiques m\u00e9taboliques autosomiques r\u00e9cessives dues \u00e0 des dysfonctionnements dans diff\u00e9rentes enzymes impliqu\u00e9es dans le m\u00e9tabolisme du glyoxylate qui conduisent \u00e0 une surproduction d\u2019oxalate dans le foie.<sup>2,3<\/sup> Il existe 3 types d\u2019HP : l\u2019HP1, l\u2019HP2 et l\u2019HP3, chacune caus\u00e9e par le dysfonctionnement d\u2019une enzyme diff\u00e9rente.<sup>3<\/sup><\/p><p>L\u2019HP1 se manifeste souvent par des calculs r\u00e9naux et survient en raison de mutations autosomiques r\u00e9cessives du g\u00e8ne <em>AGXT <\/em>, qui alt\u00e8rent la fonction de l\u2019alanine-glyoxylate aminotransf\u00e9rase (AGT), une enzyme sp\u00e9cifique du foie.<sup>1,3<\/sup> Dans une situation normale, l\u2019AGT m\u00e9tabolise le glyoxylate, qui est produit par une autre enzyme h\u00e9patique, la glycolate oxydase (GO).<sup>2,3<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d571f52 elementor-widget elementor-widget-text-editor\" data-id=\"d571f52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>\u00c9coutez le Dr Moochhala expliquer le lien entre la consanguinit\u00e9 et le risque d\u2019HP1<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e74db1 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"3e74db1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/dr-shabbir-moochhala-fr.jpg&quot;,&quot;id&quot;:8751,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Dr. Moochhala KOL video&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1143806176?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/dr-shabbir-moochhala-fr.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Dr. Moochhala KOL video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b285e0f elementor-widget elementor-widget-text-editor\" data-id=\"b285e0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prenez-vous en consid\u00e9ration la consanguinit\u00e9 lorsque vous \u00e9valuez des patients pr\u00e9sentant des calculs r\u00e9naux ? D\u00e9couvrez pourquoi cela peut \u00eatre d\u00e9terminant en cas de calculs r\u00e9naux inexpliqu\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9580d8 elementor-widget elementor-widget-n-accordion\" data-id=\"c9580d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2110\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2110\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Lire la transcription compl\u00e8te ici <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"icon icon-up-arrow1\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"icon icon-down-arrow1\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2110\" class=\"elementor-element elementor-element-70367a0 e-con-full e-flex e-con e-child\" data-id=\"70367a0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c16448f elementor-widget elementor-widget-text-editor\" data-id=\"c16448f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dr Moochhala : \u00ab\u00a0HP1\u00a0\u00bb est une abr\u00e9viation qui signifie \u00ab\u00a0hyperoxalurie primitive de type 1\u00a0\u00bb. Le terme \u00ab\u00a0primitive\u00a0\u00bb veut dire qu\u2019il s\u2019agit d\u2019une maladie g\u00e9n\u00e9tique. \u00ab\u00a0Hyperoxalurie \u00bb signifie qu\u2019il y a un exc\u00e8s d\u2019oxalate dans les urines. L\u2019oxalate est un produit de d\u00e9gradation. Et \u00ab type 1\u00a0\u00bb nous indique que l\u2019anomalie provient d&rsquo;une enzyme sp\u00e9cifique. Il existe un certain nombre d\u2019effets nocifs li\u00e9s \u00e0 la surproduction d\u2019oxalate dans l\u2019organisme. L\u2019oxalate se d\u00e9pose d\u2019abord dans les reins, ce qui entraine des calculs r\u00e9naux mais entra\u00eene \u00e9galement la calcification des reins.<\/p><p>Il peut aussi se d\u00e9poser dans n\u2019importe quel tissu mou. Par exemple, la peau, les yeux, le c\u0153ur, les muscles, tous les tissus mous. Et comme ce d\u00e9p\u00f4t est d\u00e9finitif, il peut r\u00e9duire le fonctionnement de ce tissu sp\u00e9cifique. C\u2019est pourquoi cette maladie progressive est tellement dangereuse, et c\u2019est la raison pour laquelle nous souhaitons la traiter le plus t\u00f4t possible. Souvent, le seul signe chez un patient peut \u00eatre la survenue de calculs r\u00e9naux pendant une certaine p\u00e9riode. C\u2019est une maladie tr\u00e8s rare et c\u2019est pourquoi elle est si difficile \u00e0 diagnostiquer.<\/p><p>Mais nous avons des indices, tels que les ant\u00e9c\u00e9dents familiaux. Nous commen\u00e7ons \u00e0 observer certaines tendances, l\u2019une d\u2019elles \u00e9tant une pr\u00e9valence plus \u00e9lev\u00e9e d\u2019HP1 chez les patients issus de certaines r\u00e9gions du globe, notamment d\u2019Asie du Sud-Est, du Moyen-Orient et d\u2019Afrique du Nord. Mon message pour tous les cliniciens, partout o\u00f9 qu\u2019ils voient des patients et doivent diagnostiquer des maladies rares, est de se demander en cas de calculs r\u00e9naux, \u00ab\u00a0Quelle est la cause de ces calculs\u00a0?\u00a0\u00bb Je pense que, comme pour toute autre maladie ou pr\u00e9sentation clinique, o\u00f9 nous nous demandons, \u00ab\u00a0Quelle en est la raison\u00a0?\u00a0\u00bb, nous devons penser de la m\u00eame fa\u00e7on chez les patients atteints de calculs r\u00e9naux. Nous devons nous demander, \u00ab\u00a0Vous avez eu plusieurs calculs r\u00e9naux sur une certaine p\u00e9riode. Pourquoi ?\u00a0\u00bb \u00ab\u00a0Avons-nous r\u00e9fl\u00e9chi aux causes possibles\u00a0?\u00a0\u00bb \u00ab\u00a0Avons-nous fait des investigations\u00a0?\u00a0\u00bb \u00ab\u00a0Avons-nous orient\u00e9 le patient vers un sp\u00e9cialiste qui pourrait faire des examens plus approfondis\u00a0?\u00a0\u00bb C\u2019est de cette fa\u00e7on que nous pourrons faire le diagnostic, non seulement de maladies fr\u00e9quentes, mais aussi de maladies rares. Si vous pensez que vous observez quelque chose d\u2019inhabituel, par exemple un patient qui pourrait pr\u00e9senter une l\u00e9g\u00e8re atteinte r\u00e9nale, mais avec des ant\u00e9c\u00e9dents familiaux importants, ou en cas de quantit\u00e9 inhabituelle de calculs r\u00e9naux chez un jeune patient, adressez ce patient \u00e0 un n\u00e9phrologue. Le diagnostic pr\u00e9coce de l\u2019HP1 est absolument essentiel. Vous pourrez ainsi commencer au plus t\u00f4t \u00e0 stabiliser la fonction r\u00e9nale du patient. Et, si possible, \u00e0 r\u00e9duire voire pr\u00e9venir la formation ult\u00e9rieure de calculs. Soyez pers\u00e9v\u00e9rants. Si vous pensez qu\u2019il y a un probl\u00e8me, je pr\u00e9f\u00e8re voir ce patient et constater que tout est normal, plut\u00f4t que de passer \u00e0 c\u00f4t\u00e9 d\u2019une maladie rare telle que l\u2019HP1, ou d\u2019une autre maladie rare avec formation de calculs r\u00e9naux. Je r\u00e9p\u00e8te : soyez pers\u00e9v\u00e9rants.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fee24f6 e-flex e-con-boxed e-con e-parent\" data-id=\"fee24f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3946a00 e-con-full e-flex e-con e-child\" data-id=\"3946a00\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-873fbc6 elementor-widget elementor-widget-heading\" data-id=\"873fbc6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LE DIAGNOSTIC PR\u00c9COCE DE L\u2019HP1 PEUT CONTRIBUER \u00c0 ATT\u00c9NUER LES L\u00c9SIONS R\u00c9NALES<sup>2\u20136<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f3883e0 e-grid e-con-boxed e-con e-child\" data-id=\"f3883e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d30176f e-con-full e-flex e-con e-child\" data-id=\"d30176f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b9e8c43 elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"b9e8c43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" height=\"88\" viewBox=\"0 0 88 88\" width=\"88\"><g fill=\"none\" fill-rule=\"evenodd\"><g fill-rule=\"nonzero\"><g><g><g fill=\"#1F99D5\"><path d=\"M28.8 31.6c-.2-3-2-6.3-4.6-9l-.3-.3c-.1-.1-.2-.1-.3-.2-1.3-1.2-2.8-2.2-4.2-2.8-.7-.4-1.5-.9-2.2-1.3-2.2-1.2-4.6-2.6-6.6-4.1l-.2-.2c-.7-.6-1.4-1.2-2-1.8l-.4-.4h11.4c.7 0 1.3-.6 1.3-1.3 0-.7-.6-1.3-1.3-1.3H6.3l-.1-.1C5.3 7 4.9 5.1 5.1 3c0-.5-.1-1.1-.5-1.5-.4-.4-.9-.7-1.4-.7C2.1.7 1.1 1.6 1 2.7c-.2 3.6.6 6.7 2.5 9.6 2.3 3.9 7.3 6.7 11.6 9.1.6.3 1.1.6 1.7 1 .2.2.4.3.6.4l.1.1c1.5.9 2.5 1.5 3.3 2.1 2.1 1.9 3.5 4.3 3.9 6.4v.3H11.3c-.7 0-1.3.6-1.3 1.3 0 .7.6 1.3 1.3 1.3h13.4v.2c-.4 3.2-1.8 5.4-5.2 7.6-.5.3-.8.8-.9 1.3-.1.5 0 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transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000)\"><\/path><g><path d=\"M18.3 1.4c-.4-.4-.9-.5-1.5-.5-1.1.1-2 1.1-1.9 2.2v1.2h-.2H1.3C.6 4.3 0 4.9 0 5.6c0 .7.6 1.3 1.3 1.3h13.4l-.1.3c-.7 2.4-2.3 4.6-4.9 6.6-.9.7-1 2-.4 2.9.4.5 1 .8 1.6.8.5 0 .9-.2 1.3-.4 5-3.9 7.3-8.6 6.9-14.2-.1-.7-.4-1.2-.8-1.5z\" fill=\"#1F2756\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000) translate(10.000000, 0.000000)\"><\/path><path d=\"M12.1 16.9c-.4.3-.8.4-1.3.4-.6 0-1.2-.3-1.6-.8-.7-.9-.5-2.2.4-2.9 2.6-2 4.2-4.2 4.9-6.6l.1-.3H1.3C.6 6.7 0 6.1 0 5.4c0-.7.6-1.3 1.3-1.3h13.6L15 4v-.9C14.9 2 15.8 1 16.9.9c.5 0 1.1.1 1.5.5.3.3.6.8.6 1.4.4 5.6-1.8 10.2-6.9 14.1z\" fill=\"#062059\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000) translate(10.000000, 0.000000)\"><\/path><\/g><path d=\"M19 60H6.2l.1-.3c.6-2.6 2.3-5 5.1-7.2.9-.7 1-2 .4-2.9-.3-.4-.8-.7-1.4-.8h-.3c-.5 0-.9.2-1.3.4-5 3.9-7.3 8.6-6.9 14.2.1 1.1 1.1 2 2.2 1.9.5 0 1-.3 1.4-.7.4-.4.5-.9.5-1.5V62.5h13c.7 0 1.3-.6 1.3-1.3 0-.6-.6-1.2-1.3-1.2z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000)\"><\/path><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tL\u2019HP1 est le type d\u2019HP le plus fr\u00e9quent et le plus s\u00e9v\u00e8re<sup>1,3,7<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14f6f1d elementor-widget elementor-widget-text-editor\" data-id=\"14f6f1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDans 70 % \u00e0 80 % des cas, l\u2019HP est une HP1. N\u00e9anmoins, l\u2019HP1 est une maladie rare, qui touche environ 1 \u00e0 3 personnes par million d\u2019habitants, avec un taux d\u2019incidence de 1 cas pour 120 000 naissances vivantes par an en Europe et une pr\u00e9valence plus \u00e9lev\u00e9e dans les r\u00e9gions du Moyen-Orient et d\u2019Afrique du Nord.<sup>1,3,7<\/sup> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-818527c e-con-full e-flex e-con e-child\" data-id=\"818527c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-87bac69 elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"87bac69\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"88\" height=\"88\" viewBox=\"0 0 88 88\"><g fill=\"none\" fill-rule=\"nonzero\"><path fill=\"#1E2656\" d=\"M23.362 54c-5.525 0-10.079-2.679-13.562-7.982a22.931 22.931 0 0 1-3.276-9.555c-.207-1.182-.306-2.375-.393-3.514L6 31.419v-.205c.11-3.45.459-7.451 2.577-11.139 3.702-6.312 9.27-9.349 16.576-9.056 2.543.014 5.034.715 7.207 2.028 3.647 2.343 5.547 5.922 5.634 10.64a10.146 10.146 0 0 1-.906 4.544 1.68 1.68 0 0 1-2.89.27 1.655 1.655 0 0 1-.157-1.658c.443-.97.652-2.028.612-3.091-.077-3.59-1.42-6.182-4.117-7.906a10.647 10.647 0 0 0-5.514-1.508c-5.61-.482-10.96 2.442-13.551 7.408-1.584 2.7-1.999 5.704-2.13 9.478 0 .489.088.977.12 1.454.099 1.15.186 2.234.339 3.308a19.93 19.93 0 0 0 2.806 8.22c2.85 4.339 6.377 6.508 10.767 6.508h.874a7.85 7.85 0 0 0 5.83-2.755c1.748-2.071 2.589-5.238-.283-7.906a1.664 1.664 0 0 1 .605-2.916 1.689 1.689 0 0 1 1.688.486A8.651 8.651 0 0 1 35.013 44a9.562 9.562 0 0 1-2.347 6.02 11.145 11.145 0 0 1-8.201 3.947L23.362 54z\"><\/path><path fill=\"#2098D5\" d=\"M37.468 35.62c-2.727-3.29-6.761-5.023-10.007-6.153a12.252 12.252 0 0 0-1.42-2.403 6.616 6.616 0 0 0 1.533-1.865l1.499-2.5c.162-.255.21-.563.134-.853a1.101 1.101 0 0 0-.54-.683 1.153 1.153 0 0 0-.878-.127c-.298.077-.55.27-.7.532l-1.532 2.49a5.544 5.544 0 0 1-.834 1.207 6.504 6.504 0 0 1-1.127-2.358 1.13 1.13 0 0 0-.763-.838c-.39-.126-.82-.04-1.127.225-.307.266-.446.67-.363 1.062a11.553 11.553 0 0 0 2.32 4.388c.65.781 1.206 1.631 1.657 2.534.08.175.147.355.203.538.143.432.212.884.203 1.338a4.302 4.302 0 0 1-.63 2.106 8.883 8.883 0 0 1-2.683 2.732l-4.417-1.997-1.51-.416a1.193 1.193 0 0 0-1.134.282 1.12 1.12 0 0 0-.315 1.097c.103.394.415.705.818.815l1.34.373 2.784 1.25c-.906.427-1.854.765-2.828 1.01a1.126 1.126 0 0 0-.708.491c-.159.25-.208.55-.138.836.123.506.594.858 1.127.844.094.011.188.011.282 0a19.037 19.037 0 0 0 5.127-2.194 1.13 1.13 0 0 0 .665-.416 11.331 11.331 0 0 0 3.572-3.599 6.47 6.47 0 0 0 .846-2.281 16.935 16.935 0 0 1 6.952 4.552c3.313 3.993 3.088 9.763 2.322 13.899-.372 1.996-.913 4.015-1.431 5.978a54.344 54.344 0 0 0-1.95 9.742 27.935 27.935 0 0 0 .642 8.468c.165.738.836 1.264 1.612 1.262.123.016.248.016.372 0 .437-.086.82-.342 1.06-.708.24-.366.317-.811.213-1.234a24.644 24.644 0 0 1-.563-7.547c.34-3.108.961-6.18 1.859-9.182.53-2.018 1.127-4.091 1.476-6.198.868-4.804 1.07-11.562-3.02-16.498z\"><\/path><path fill=\"#1E2656\" d=\"M64.674 54c5.524 0 10.077-2.679 13.56-7.982a22.934 22.934 0 0 0 3.275-9.555c.174-1.182.273-2.375.36-3.514l.131-1.53v-.205c-.12-3.45-.426-7.451-2.587-11.139-3.701-6.312-9.27-9.349-16.573-9.056a14.076 14.076 0 0 0-7.206 2.028c-3.646 2.343-5.546 5.922-5.633 10.64a10.15 10.15 0 0 0 1.004 4.544 1.68 1.68 0 0 0 2.222.819 1.66 1.66 0 0 0 .824-2.207 6.815 6.815 0 0 1-.611-3.091c.076-3.59 1.42-6.182 4.116-7.906a10.643 10.643 0 0 1 5.459-1.508c5.609-.482 10.957 2.442 13.548 7.408 1.583 2.7 1.998 5.737 2.184 9.478 0 .489-.088.977-.12 1.454-.099 1.15-.186 2.234-.339 3.308a19.932 19.932 0 0 1-2.806 8.22c-2.85 4.339-6.375 6.508-10.764 6.508h-.874a7.848 7.848 0 0 1-5.83-2.755c-1.746-2.071-2.587-5.238.284-7.906a1.662 1.662 0 0 0-.016-2.267 1.69 1.69 0 0 0-2.276-.163A8.652 8.652 0 0 0 53.08 44a9.562 9.562 0 0 0 2.292 6.02 11.142 11.142 0 0 0 8.2 3.947l1.102.033z\"><\/path><path fill=\"#2098D5\" d=\"M50.532 35.62c2.727-3.29 6.761-5.023 10.006-6.153.38-.85.856-1.656 1.42-2.403a6.616 6.616 0 0 1-1.532-1.865l-1.465-2.5a1.072 1.072 0 0 1-.135-.853c.077-.29.272-.537.54-.683.263-.158.58-.203.879-.127.298.077.55.27.699.532l1.499 2.49c.222.437.503.842.834 1.207a6.504 6.504 0 0 0 1.126-2.358c.128-.606.736-.997 1.358-.872a1.12 1.12 0 0 1 .896 1.321 11.553 11.553 0 0 1-2.321 4.388 13.221 13.221 0 0 0-1.657 2.534 4.41 4.41 0 0 0-.202.538 4.024 4.024 0 0 0-.203 1.338c.023.743.24 1.468.63 2.106a8.883 8.883 0 0 0 2.683 2.732l4.417-1.997 1.51-.416c.622-.17 1.268.184 1.442.79a1.136 1.136 0 0 1-.811 1.404l-1.34.373-2.784 1.25c.906.427 1.853.765 2.828 1.01.294.064.549.242.708.491.159.25.208.55.137.836a1.122 1.122 0 0 1-1.127.844c-.093.011-.188.011-.281 0a19.036 19.036 0 0 1-5.128-2.194 1.13 1.13 0 0 1-.664-.416 11.331 11.331 0 0 1-3.573-3.599 6.47 6.47 0 0 1-.845-2.281 16.935 16.935 0 0 0-6.952 4.552c-3.313 3.993-3.088 9.763-2.322 13.899.372 1.996.913 4.015 1.431 5.978a54.344 54.344 0 0 1 1.95 9.742 27.936 27.936 0 0 1-.642 8.468c-.165.738-.836 1.264-1.612 1.262a1.435 1.435 0 0 1-.372 0 1.646 1.646 0 0 1-1.06-.708 1.566 1.566 0 0 1-.213-1.234c.575-2.474.765-5.018.563-7.547a51.605 51.605 0 0 0-1.859-9.182c-.53-2.018-1.127-4.091-1.476-6.198-.868-4.804-1.07-11.562 3.02-16.498z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tL\u2019HP1 peut entra\u00eener des l\u00e9sions r\u00e9nales irr\u00e9versibles<sup>1,3<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c89fb0b elementor-widget elementor-widget-text-editor\" data-id=\"c89fb0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tL\u2019un des aspects les plus d\u00e9vastateurs de l\u2019HP1 est qu\u2019elle provoque un d\u00e9clin progressif de la fonction r\u00e9nale, qui conduit \u00e0 terme \u00e0 une insuffisance r\u00e9nale terminale (IRT).<sup>1,3,6<\/sup> De plus, il existe un risque potentiel d\u2019oxalose syst\u00e9mique.<sup>3,8<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f51863f e-con-full e-flex e-con e-child\" data-id=\"f51863f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb0223d elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"cb0223d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" height=\"88\" viewBox=\"0 0 88 88\" width=\"88\"><g fill=\"none\" fill-rule=\"evenodd\"><g fill-rule=\"nonzero\"><g><g><g><path d=\"M1.2 47.1c0 .3-.7 5.5-.2 13.4.1 2.2 1.9 3.9 4.1 3.9h17.5c2.2 0 4-1.7 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60.5h3.1c1.6 0 2.9-1.3 2.9-2.9V56c0-.5-.4-1-1-1-.5 0-1 .4-1 1v1.6c0 .5-.4 1-1 1h-3.1c-.5 0-1 .4-1 1 .1.4.6.9 1.1.9zM9.9 14.8c-2 .8-3.4 2.7-3.7 5.2-.1.5.3 1 .8 1.1h.1c.5 0 .9-.4 1-.8.2-1.7 1.1-3.1 2.5-3.6.5-.2.7-.7.6-1.2-.3-.6-.8-.9-1.3-.7z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(22.000000, 0.000000)\"><\/path><\/g><g><path d=\"M1.2 37.5c0 .2-.6 4.4-.2 10.8.1 1.7 1.6 3.1 3.3 3.1h14c1.7 0 3.2-1.4 3.3-3.1.4-5.9-.2-10.7-.2-10.8-.2-2.1-.7-4.3-1.5-6.8-.8-2.3-1.1-5.1.1-7.2.7-1.4 1.4-3.2 1.5-5 .2-7.8-4.6-10-6.4-10.5V6.6h.4c.4 0 .8-.3.8-.8V2c0-.9-.8-1.7-1.7-1.7H8.2c-.9 0-1.7.8-1.7 1.7v3.8c0 .4.3.8.8.8h.4V8c-1.8.5-6.7 2.7-6.4 10.5 0 1.3.5 3.1 1.5 5 .7 1.3 1.2 3.5.1 7.2-.9 2.4-1.4 4.7-1.7 6.8zm18.9 1.6c.2 2.8.3 5.8 0 9.1-.1.9-.8 1.6-1.7 1.6h-14c-.9 0-1.7-.7-1.7-1.6-.2-3.3-.2-6.3.1-9.1h17.3zM8 2c0-.1.1-.1.1-.1h6.4c.1 0 .1.1.1.1v3H7.9V2H8zm.6 7.3c.4 0 .7-.4.7-.8v-2h4.2v2c0 .4.3.7.7.8.2 0 6 .9 5.8 9H2.8c-.2-8.1 5.5-9 5.8-9zM4.1 22.7c-.8-1.4-1-2.3-1.1-2.9h16.7c-.1.5-.3 1.4-1.1 2.9s-1.5 4.3-.2 8.4c.9 2.7 1.3 4.7 1.4 6.4h-17c.3-2.2.8-4.4 1.5-6.5.9-2.7 1.2-5.8-.2-8.3z\" fill=\"#062059\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(49.000000, 10.000000)\"><\/path><path d=\"M12 23.1c-.3-.5-1-.5-1.3 0-.6.9-3.3 5.6-3.3 7.4 0 2.2 1.8 4 4 4s4-1.8 4-4c-.1-1.8-2.8-6.4-3.4-7.4zM13.7 48.2h2.4c1.3 0 2.3-1 2.3-2.3v-1.3c0-.4-.3-.8-.8-.8-.4 0-.8.3-.8.8v1.3c0 .4-.3.8-.8.8h-2.4c-.4 0-.8.3-.8.8s.5.7.9.7zM8.2 11.6c-1.6.6-2.7 2.2-3 4.1-.1.4.3.8.7.9H6c.4 0 .7-.3.8-.7.2-1.4.9-2.5 2-2.9.4-.2.6-.6.4-1-.1-.4-.6-.6-1-.4z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(49.000000, 10.000000)\"><\/path><\/g><g><path d=\"M1.1 37.5c0 .2-.6 4.4-.2 10.8.1 1.7 1.5 3.1 3.3 3.1h14c1.7 0 3.2-1.4 3.3-3.1.4-5.9-.2-10.7-.2-10.8-.2-2.1-.7-4.3-1.5-6.8-.8-2.3-1.1-5.1.1-7.2.7-1.4 1.4-3.2 1.5-5 .2-7.8-4.6-10-6.4-10.5V6.6h.4c.4 0 .8-.3.8-.8V2c0-.9-.8-1.7-1.7-1.7H8c-.9 0-1.7.8-1.7 1.7v3.8c0 .4.3.8.8.8h.4V8c-1.8.5-6.7 2.7-6.4 10.5 0 1.3.5 3.1 1.5 5 .7 1.3 1.2 3.5.1 7.2-.9 2.4-1.4 4.7-1.6 6.8zm18.8 1.6c.2 2.8.3 5.8 0 9.1-.1.9-.8 1.6-1.7 1.6h-14c-.9 0-1.7-.7-1.7-1.6-.2-3.3-.2-6.3.1-9.1h17.3zM7.8 2c0-.1.1-.1.1-.1h6.4c.1 0 .1.1.1.1v3H7.7V2h.1zm.6 7.3c.4 0 .7-.4.7-.8v-2h4.2v2c0 .4.3.7.7.8.2 0 6 .9 5.8 9H2.6c-.2-8.1 5.5-9 5.8-9zM3.9 22.7c-.8-1.4-1-2.3-1.1-2.9h16.7c-.1.5-.3 1.4-1.1 2.9s-1.5 4.3-.2 8.4c.9 2.7 1.3 4.7 1.4 6.4h-17c.3-2.2.8-4.4 1.5-6.5.9-2.7 1.2-5.8-.2-8.3z\" fill=\"#062059\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(0.000000, 10.000000)\"><\/path><path d=\"M11.8 23.1c-.3-.5-1-.5-1.3 0-.6.9-3.3 5.6-3.3 7.4 0 2.2 1.8 4 4 4s4-1.8 4-4c-.1-1.8-2.8-6.4-3.4-7.4zM13.5 48.2H16c1.3 0 2.3-1 2.3-2.3v-1.3c0-.4-.3-.8-.8-.8-.4 0-.8.3-.8.8v1.3c0 .4-.3.8-.8.8h-2.4c-.4 0-.8.3-.8.8s.4.7.8.7zM8 11.6c-1.6.6-2.7 2.2-3 4.1-.1.4.3.8.7.9h.1c.4 0 .7-.3.8-.7.2-1.4.9-2.5 2-2.9.4-.1.6-.6.4-1-.1-.4-.6-.6-1-.4z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(0.000000, 10.000000)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tUn diagnostic et une intervention pr\u00e9coces sont essentiels afin de limiter l\u2019apparition de l\u00e9sions irr\u00e9versibles<sup>2\u20136<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba163fe elementor-widget elementor-widget-text-editor\" data-id=\"ba163fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLes m\u00e9thodes de prise en charge permettent de limiter l\u2019apparition de l\u00e9sions en r\u00e9duisant la formation de calculs et le d\u00e9p\u00f4t de cristaux d\u2019oxalate de calcium ; ceci souligne l\u2019importance de diagnostiquer et d\u2019intervenir pr\u00e9cocement.<sup>3,7,8<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-834924a e-flex e-con-boxed e-con e-parent\" data-id=\"834924a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d45841f elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d45841f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/connaitre-les-signes\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conna\u00eetre les signes<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-81dc0fb elementor-widget elementor-widget-heading\" data-id=\"81dc0fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u2019HP1 EST PROGRESSIVE ET SYST\u00c9MIQUE<sup>2,9<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb170e3 elementor-widget elementor-widget-heading\" data-id=\"fb170e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Comprendre pourquoi l\u2019HP1 peut \u00eatre potentiellement mortelle<sup>2<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8ed625 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"d8ed625\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/Video-HP1-France-GO1-FRA-00006.jpg&quot;,&quot;id&quot;:6972,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Lorsque les calculs r\\u00e9naux peuvent \\u00eatre le signe de quelque chose de plus grave - Vignette de vid\\u00e9o&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1049640211?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1&amp;h=e4a1dc59d2#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/Video-HP1-France-GO1-FRA-00006.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Lorsque les calculs r\u00e9naux peuvent \u00eatre le signe de quelque chose de plus grave - Vignette de vid\u00e9o\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c0ab795 elementor-widget elementor-widget-text-editor\" data-id=\"c0ab795\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tL\u2019HP1 entra\u00eene un d\u00e9clin progressif de la fonction r\u00e9nale.<sup>2<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-18b58b1 e-flex e-con-boxed e-con e-parent\" data-id=\"18b58b1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-490699c elementor-widget elementor-widget-heading\" data-id=\"490699c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">UN EXC\u00c8S D\u2019OXALATE PEUT ENDOMMAGER LES REINS<sup>9<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9e086d elementor-widget elementor-widget-text-editor\" data-id=\"e9e086d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Une surproduction h\u00e9patique d\u2019oxalate peut entra\u00eener une inflammation et une diminution progressive de la fonction r\u00e9nale suite \u00e0 la formation de cristaux d\u2019oxalate de calcium.<sup>8,9<\/sup> Une surproduction continue d\u2019oxalate peut entra\u00eener des l\u00e9sions irr\u00e9versibles dans les reins et d\u2019autres organes.<sup>8,9<\/sup><\/p>\n<p>L\u2019HP1 \u00e9volue en IRT \u00e0 une vitesse variable.<sup>2<\/sup> Lorsque les reins sont incapables d\u2019excr\u00e9ter efficacement l\u2019oxalate en raison de la toxicit\u00e9 des d\u00e9p\u00f4ts de cristaux d\u2019oxalate de calcium, une oxalose syst\u00e9mique, c\u2019est-\u00e0-dire un d\u00e9p\u00f4t g\u00e9n\u00e9ralis\u00e9 d\u2019oxalate de calcium dans les tissus, peut se produire.<sup>9<\/sup> Les complications de l\u2019oxalose syst\u00e9mique peuvent \u00eatre fatales.<sup>2<\/sup><\/p>\n<p>Dans certains cas, la fonction r\u00e9nale peut diminuer apr\u00e8s un seul \u00e9v\u00e9nement de d\u00e9shydratation d\u00fb \u00e0 une maladie aigu\u00eb ou \u00e0 une activit\u00e9 physique intense.<sup>10\u201313<\/sup> Cela peut se produire m\u00eame chez des patients dont la maladie \u00e9tait stable auparavant.<sup>9,11<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6c8909 e-flex e-con-boxed e-con e-parent\" data-id=\"c6c8909\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-03585b9 e-flex e-con-boxed e-con e-child\" data-id=\"03585b9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b15ab3d elementor-widget elementor-widget-heading\" data-id=\"b15ab3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">QUELLES SONT LES CAUSES DE LA SURPRODUCTION D\u2019OXALATE DANS L\u2019HP1 ?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1da21d elementor-widget elementor-widget-heading\" data-id=\"c1da21d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Incapacit\u00e9 de l\u2019AGT \u00e0 m\u00e9taboliser le glyoxylate produit par l\u2019enzyme GO<sup>2<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ba4b4cd e-grid e-con-boxed e-con e-child\" data-id=\"ba4b4cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef80976 elementor-widget elementor-widget-text-editor\" data-id=\"ef80976\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019HP1 est une maladie g\u00e9n\u00e9tique provoqu\u00e9e par des mutations du g\u00e8ne <em>AGXT<\/em> qui rend l\u2019enzyme h\u00e9patique AGT dysfonctionnelle.<sup class=\"sup\">3<\/sup><\/p><p class=\"mb-70 mob-mb-40\">Dans une situation normale, l\u2019AGT m\u00e9tabolise le glyoxylate, qui est produit par une autre enzyme h\u00e9patique, la GO.<sup class=\"sup\">2,3<\/sup> Dans l\u2019HP1, l\u2019AGT mut\u00e9e ne peut plus m\u00e9taboliser le glyoxylate. Il sera alors converti en oxalate par la GO.<sup class=\"sup\">2<\/sup> L\u2019oxalate ne peut pas \u00eatre m\u00e9tabolis\u00e9 et doit \u00eatre excr\u00e9t\u00e9 par les reins mais,<sup class=\"sup\">3<\/sup> dans l\u2019HP1, l\u2019oxalate peu soluble et produit en exc\u00e8s ne sera pas correctement \u00e9limin\u00e9.<sup class=\"sup\">2<\/sup> L\u2019oxalate en exc\u00e8s se combine alors avec le calcium pour cr\u00e9er des cristaux d\u2019oxalate de calcium.<sup class=\"sup\">2<\/sup> L\u2019oxalate de calcium peut se d\u00e9poser dans les tissus r\u00e9naux et entra\u00eener une n\u00e9phrocalcinose ou s\u2019agr\u00e9ger pour former des calculs r\u00e9naux, provoquant des dommages irr\u00e9versibles.<sup class=\"sup\">2,9<\/sup> Au fur et \u00e0 mesure que l\u2019oxalate de calcium s\u2019accumule, l\u2019excr\u00e9tion r\u00e9nale est alt\u00e9r\u00e9e et des cristaux se d\u00e9posent dans tout l\u2019organisme.<sup>9<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-545ff66 e-flex e-con-boxed e-con e-child\" data-id=\"545ff66\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-579544e elementor-widget elementor-widget-heading\" data-id=\"579544e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">T\u00e9l\u00e9charger la brochure sur l\u2019HP1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f62fbc elementor-widget elementor-widget-image\" data-id=\"4f62fbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"504\" height=\"736\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/Brochure-HP1-PH1-FRA-00009.jpg\" class=\"attachment-full size-full wp-image-6980\" alt=\"HP1 - Vue d\u2019ensemble - Miniature de brochure\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/Brochure-HP1-PH1-FRA-00009.jpg 504w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/Brochure-HP1-PH1-FRA-00009-205x300.jpg 205w\" sizes=\"(max-width: 504px) 100vw, 504px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1af67c3 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"1af67c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/downloads\/fr\/PH1-FRA-00009_Brochure_sur_lHP1.pdf\" target=\"_blank\" download=\"Brochure-sur-lHP1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"15\" viewBox=\"0 0 16 15\"><path fill=\"#D0191F\" fill-rule=\"evenodd\" d=\"M14.28 7.58a.5.5 0 0 1 1 0v4.825c0 .643-.263 1.227-.685 1.65a2.332 2.332 0 0 1-1.65.685H2.335a2.328 2.328 0 0 1-1.65-.685A2.324 2.324 0 0 1 0 12.405V7.58a.5.5 0 0 1 1 0v4.825a1.335 1.335 0 0 0 1.334 1.334h10.611a1.338 1.338 0 0 0 1.334-1.334V7.58zm-9.958-.854a.5.5 0 0 1 .707-.707l2.111 2.11V.5a.5.5 0 0 1 1 0v7.63l2.11-2.11a.5.5 0 0 1 .707.707l-2.96 2.96a.453.453 0 0 1-.032.03l-.018.015-.004.003-.008.006-.008.006-.005.004-.004.002-.006.005-.004.003-.006.003-.008.005a.508.508 0 0 1-.508 0l-.009-.005-.004-.003-.004-.003-.008-.005-.002-.002-.006-.004-.008-.006h-.002l-.005-.006-.004-.003a.173.173 0 0 1-.02-.014c-.012-.01-.02-.02-.03-.031l-2.962-2.96z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">T\u00e9l\u00e9charger<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-06906e6 e-flex e-con-boxed e-con e-parent\" data-id=\"06906e6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-88643fd e-con-full e-flex e-con e-child\" data-id=\"88643fd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5196e77 elementor-widget elementor-widget-image\" data-id=\"5196e77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"247\" height=\"249\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle.png\" class=\"attachment-large size-large wp-image-6953\" alt=\"Kim Hollander - Directrice ex\u00e9cutive de la Oxalosis and Hyperoxaluria Foundation\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle.png 247w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle-150x150.png 150w\" sizes=\"(max-width: 247px) 100vw, 247px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-11e20b3 e-con-full e-flex e-con e-child\" data-id=\"11e20b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22d351c elementor-widget elementor-widget-text-editor\" data-id=\"22d351c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00ab \u00c9tant donn\u00e9 la nature de cette maladie, il est possible que l\u2019HP1 ne soit pas diagnostiqu\u00e9e pendant des ann\u00e9es. Les sympt\u00f4mes pr\u00e9coces chez l\u2019adulte, tels que les calculs r\u00e9naux, sont souvent attribu\u00e9s \u00e0 d\u2019autres affections plus fr\u00e9quentes. Nous devons aider les m\u00e9decins \u00e0 reconna\u00eetre les sympt\u00f4mes plus rapidement, afin d\u2019arr\u00eater la progression de la maladie chez le patient, avant qu\u2019elle ne provoque une insuffisance r\u00e9nale terminale. \u00bb<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c2cfe8 elementor-widget elementor-widget-text-editor\" data-id=\"6c2cfe8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Kim Hollander<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a69df67 person-role elementor-widget elementor-widget-text-editor\" data-id=\"a69df67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDirectrice ex\u00e9cutive de la <a style=\"color: #1f99d5;\" href=\"https:\/\/ohf.org\/\" rel=\"nofollow\" class=\"external\">Fondation pour l\u2019oxalose et l\u2019hyperoxalurie<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe7e8fc e-flex e-con-boxed e-con e-parent\" data-id=\"fe7e8fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-094ad73 elementor-hidden-tablet elementor-hidden-mobile elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"094ad73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc862c8 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"dc862c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/connaitre-les-signes\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">D\u00c9COUVRIR <span>LES SIGNES<span style=\"background-color: var( --e-global-color-5a8cfc1 );color: var( --e-global-color-accent );font-size: 32px\"><\/span><\/span><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e996090 e-flex e-con-boxed e-con e-parent\" data-id=\"e996090\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4dda9423 e-con-full e-flex e-con e-child\" data-id=\"4dda9423\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27f870e6 elementor-widget elementor-widget-heading\" data-id=\"27f870e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Test de d\u00e9pistage de l\u2019HP1 chez les patients<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33003895 elementor-widget elementor-widget-text-editor\" data-id=\"33003895\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e9couvrez le r\u00f4le important que jouent les tests g\u00e9n\u00e9tiques dans le diagnostic de l\u2019HP1.<sup>2,4<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61982d65 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"61982d65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/depistage-de-lhp1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Options de d\u00e9pistage<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2525b1e4 e-con-full e-flex e-con e-child\" data-id=\"2525b1e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b4575f8 elementor-widget elementor-widget-heading\" data-id=\"5b4575f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Obtenir des mises \u00e0 jour<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37f042f4 elementor-widget elementor-widget-text-editor\" data-id=\"37f042f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>S\u2019inscrire pour recevoir des informations d\u2019Alnylam sur l\u2019HP1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3b7360 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"b3b7360\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">S\u2019inscrire<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ae63e4 e-flex e-con-boxed e-con e-parent\" data-id=\"1ae63e4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-478a2d1 elementor-widget elementor-widget-text-editor\" data-id=\"478a2d1\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"footer-refs\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>R\u00e9f\u00e9rences : 1.<\/strong> Hoppe B. <em>Nat Rev Nephrol.<\/em> 2012;8(8):467\u2013475. <strong>2.<\/strong> Milliner DS, Harris PC, Sas DJ, <em>et al.<\/em> Primary hyperoxaluria type 1. GeneReviews<sup>\u00ae<\/sup> [<em>Internet<\/em>]. Mis \u00e0 jour le 15 ao\u00fbt 2024. Dernier acc\u00e8s en f\u00e9vrier 2026. <strong>3.<\/strong> Cochat P, Rumsby G. <em>N Engl J Med.<\/em> 2013;369(7):649\u2013658. <strong>4.<\/strong> Cochat P, Hulton SA, Acquaviva C, <em>et al. Nephrol Dial Transplant.<\/em> 2012;27(5):1729\u20131736. <strong>5.<\/strong> Ben-Shalom E, Frishberg Y. <em>Pediatr Nephrol.<\/em> 2015;30(10):1781\u20131791. <strong>6.<\/strong> Raju DL, Cantarovich M, Brisson ML, <em>et al. Am J Kidney Dis.<\/em> 2008;51(1):e1\u2013e5. <strong>7.<\/strong> Bhasin B, \u00dcrekli HM, Atta MG. <em>World J Nephrol.<\/em> 2015;4(2):235\u2013244. <strong>8.<\/strong> Hoppe B, Beck BB, Milliner DS. <em>Kidney Int.<\/em> 2009;75(12):1264\u20131271. <strong>9.<\/strong> Leumann E, Hoppe B. <em>J Am Soc Nephrol.<\/em> 2001;12(9):1986\u20131993. <strong>10.<\/strong> El-Reshaid K, Al-Bader D, Madda JP. <em>Saudi J Kidney Dis Transpl.<\/em> 2016;27(3):606\u2013609. <strong>11.<\/strong> Cochat P. <em>Kidney Int.<\/em> 1999;55(6):2533\u20132547. <strong>12.<\/strong> Harambat J, Fargue S, Bacchetta J, <em>et al. Int J Nephrol.<\/em> 2011;2011:864580. <strong>13.<\/strong> Tintillier M, Pochet JM, Cosyns JP, <em>et al. Clin Nephrol.<\/em> 2004;62(2):155\u2013157.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60902a3 elementor-widget elementor-widget-text-editor\" data-id=\"60902a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>PH1-FRA-00146 I F\u00e9vrier 2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>En savoir plus sur l\u2019hyperoxalurie primaire de type 1 (HP1), maladie g\u00e9n\u00e9tique rare et progressive qui se manifeste souvent par la pr\u00e9sence de calculs r\u00e9naux et peut provoquer des l\u00e9sions r\u00e9nales irr\u00e9versibles.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-6884","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages\/6884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/comments?post=6884"}],"version-history":[{"count":93,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages\/6884\/revisions"}],"predecessor-version":[{"id":8877,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages\/6884\/revisions\/8877"}],"wp:attachment":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/media?parent=6884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}