{"id":6863,"date":"2024-06-03T13:54:12","date_gmt":"2024-06-03T13:54:12","guid":{"rendered":"https:\/\/www.thinkph1.eu\/?page_id=6863"},"modified":"2026-02-02T14:25:46","modified_gmt":"2026-02-02T14:25:46","slug":"maladie-metabolique-des-calculs-renaux","status":"publish","type":"page","link":"https:\/\/www.thinkph1.eu\/fr\/","title":{"rendered":"HP1 : Maladie m\u00e9tabolique des calculs r\u00e9naux | Think PH1\u2122"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6863\" class=\"elementor elementor-6863 elementor-22\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-094e2f1 randomBGImage e-con-full e-flex e-con e-parent\" data-id=\"094e2f1\" data-element_type=\"container\" data-e-type=\"container\" id=\"bgID\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\" data-images=\"\/wp-content\/uploads\/2024\/06\/behind-the-stone-ph1-adolescent-on-dialysis-banner-large.jpg,\/wp-content\/uploads\/2024\/06\/behind-the-stone-ph1-adult-on-dialysis-banner-large.jpg,\/wp-content\/uploads\/2024\/06\/behind-the-stone-ph1-child-on-dialysis-banner-large.jpg\">\n\t\t<div class=\"elementor-element elementor-element-c6ce04c e-flex e-con-boxed e-con e-child\" data-id=\"c6ce04c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-87b24e5 e-con-full e-flex e-con e-child\" data-id=\"87b24e5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c9ada73 eael-dual-header-content-align-left elementor-widget elementor-widget-eael-dual-color-header\" data-id=\"c9ada73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-dual-color-header.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"eael-dual-header\">\n\t\t\t\t<span class=\"subtext\"><p>DERRI\u00c8RE<\/p><\/span>\n\t\t\t\t<h2 class=\"title eael-dch-title\"><span class=\"eael-dch-title-text eael-dch-title-lead lead solid-color\">UN CALCUL,<\/span> <span class=\"eael-dch-title-text\">Y A-T-IL AUTRE CHOSE&nbsp;? <\/span><\/h2>\t\t\t\t\t\t\t\t\t<span class=\"eael-dch-svg-icon\"><\/span>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-634ad28 e-con-full e-flex e-con e-child\" data-id=\"634ad28\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-0caa92a e-con-full e-flex e-con e-child\" data-id=\"0caa92a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c4d28e4 elementor-widget elementor-widget-text-editor\" data-id=\"c4d28e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les calculs r\u00e9naux r\u00e9currents chez un adulte ou tout calcul r\u00e9nal chez un enfant peuvent \u00eatre des signes pr\u00e9coces d\u2019une maladie lithiasique m\u00e9tabolique pouvant avoir des cons\u00e9quences potentiellement d\u00e9vastatrices, telle que l\u2019hyperoxalurie primitive de type 1 (HP1).<sup>1\u20134 <\/sup> <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-caffbea elementor-align-left elementor-widget elementor-widget-button\" data-id=\"caffbea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/decouvrir-lhp1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">En savoir plus sur l\u2019HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7e2ee69 e-con-full e-flex e-con e-child\" data-id=\"7e2ee69\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f2a73f elementor-absolute e-transform elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"2f2a73f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;none&quot;,&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-24,&quot;sizes&quot;:[]},&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateX_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateX_direction&quot;:&quot;negative&quot;,&quot;motion_fx_translateX_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:5,&quot;sizes&quot;:[]},&quot;motion_fx_translateX_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1100\" height=\"474\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone.png\" class=\"attachment-full size-full wp-image-6947\" alt=\"Calculs d\u2019oxalate de calcium - Calculs r\u00e9naux\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone.png 1100w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone-300x129.png 300w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone-1024x441.png 1024w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone-768x331.png 768w\" sizes=\"(max-width: 1100px) 100vw, 1100px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0e5a07a e-flex e-con-boxed e-con e-parent\" data-id=\"0e5a07a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-be23a4b elementor-widget elementor-widget-heading\" data-id=\"be23a4b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">NE N\u00c9GLIGER AUCUN CALCUL R\u00c9NAL<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e959b14 elementor-widget elementor-widget-heading\" data-id=\"e959b14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Tout calcul inhabituel peut \u00eatre le signe d\u2019une maladie lithiasique m\u00e9tabolique, telle que l\u2019hyperoxalurie primitive de type 1, et m\u00e9rite un examen plus approfondi.<sup>1,2<\/sup><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-506f531 e-flex e-con-boxed e-con e-parent\" data-id=\"506f531\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cc978a2 e-con-full e-flex e-con e-child\" data-id=\"cc978a2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9dfb170 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"9dfb170\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" width=\"75\" height=\"71\" viewBox=\"0 0 75 71\"><g fill=\"none\" fill-rule=\"evenodd\"><g><g><g><g><path fill=\"#2098D5\" fill-rule=\"nonzero\" d=\"M23 38.987c-3.297.076-6.338-1.74-7.795-4.653-.293-.511-.27-1.141.058-1.631.329-.49.908-.758 1.501-.694.593.065 1.1.45 1.312.999.935 1.818 2.855 2.937 4.924 2.87 2.068.075 3.99-1.042 4.924-2.86.213-.548.72-.933 1.312-.998.593-.064 1.172.204 1.5.694.33.49.352 1.12.06 1.631-1.458 2.913-4.5 4.728-7.796 4.653v-.011z\" transform=\"translate(-363 -1056) translate(215 872) translate(0 184) translate(149)\"><\/path><path fill=\"#2098D5\" d=\"M44.449 35.16c-.804-6.126 2.96-9.74 7.592-10.928-.155-.515-.494-.955-.951-1.24 1.052-.102 2.101.215 2.918.882 1.127-1.351 2.867-2.043 4.621-1.839-.86.322-1.553.973-1.925 1.808 2.9.14 5.638 1.364 7.667 3.426 1.897 2.182 2.733 5.084 2.284 7.934 2.316 1.271 1.258 5.254-.307 7.167-.463.571-1.053 1.028-1.723 1.335-.672 1.697-1.79 3.185-3.236 4.308-3.474 2.65-8.306 2.65-11.78 0-1.447-1.123-2.564-2.61-3.236-4.308-.672-.304-1.263-.761-1.723-1.335-1.618-1.934-2.623-5.98-.212-7.21h.01zm8.026-4.486c-.212 1.734-2.348 7.566-4.8 6.935-.826-.262-1.873-.115-1.735 1.051.26 1.7 1.608 3.03 3.32 3.279.767 2.8 3.325 4.742 6.244 4.742 2.92 0 5.477-1.943 6.244-4.742 1.715-.247 3.066-1.577 3.331-3.279.117-1.135-.803-1.324-1.607-1.124-2.242.326-6.345-3.92-6.947-5.255.143 1.704.833 3.317 1.967 4.603-2.63-1.358-4.733-3.542-5.985-6.21h-.032z\" transform=\"translate(-363 -1056) translate(215 872) translate(0 184) translate(149)\"><\/path><path stroke=\"#1E2656\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"1.932\" d=\"M39.18 34.54l-.388-.16c-1.412-.524-2.835-1.07-3.924-1.38 1.078 9.254-8.108 6.687-11.73 13.908-3.623-7.179-12.82-4.61-11.73-13.908-1.079.321-2.513.856-3.925 1.38-1.467.554-2.663 1.645-3.343 3.05C1.876 41.708.56 55.616.011 60.42c-.126 1.395.851 2.65 2.243 2.879C9.162 64.442 16.155 65.01 23.159 65c3.623 0 7.202-.15 10.782-.439.575-3.743 1.698-7.383 3.331-10.806 1.423-3.091 3.882-4.525 6.728-5.413-.534-.694-1.004-1.435-1.402-2.215-.642-.45-1.222-.982-1.725-1.583-1.112-1.358-1.878-2.961-2.231-4.675-.442-1.75-.251-3.597.539-5.221l.064-.107h-.064z\" transform=\"translate(-363 -1056) translate(215 872) translate(0 184) translate(149)\"><\/path><path fill=\"#1E2656\" d=\"M16.895 28.739c-2.48.952-7.375 1.853-10.895.806C12.173 27.115 3.899 2.9 16.018 2.712 17.621.366 20.21 0 22.516 0c5.361 0 10.31 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1.774-2.653z\" transform=\"translate(-363 -1056) translate(215 872) translate(0 184) translate(149)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tEnfants ou adolescents\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tTout calcul ou des ant\u00e9c\u00e9dents familiaux de calculs peuvent constituer des signaux d\u2019alerte.<sup>1,3\u20135<\/sup>\n\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad70bc6 e-con-full e-flex e-con e-child\" data-id=\"ad70bc6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31a330f elementor-view-default 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3.275-9.555c.174-1.182.273-2.375.36-3.514l.131-1.53v-.205c-.12-3.45-.426-7.451-2.587-11.139-3.701-6.312-9.27-9.349-16.573-9.056a14.076 14.076 0 0 0-7.206 2.028c-3.646 2.343-5.546 5.922-5.633 10.64a10.15 10.15 0 0 0 1.004 4.544 1.68 1.68 0 0 0 2.222.819 1.66 1.66 0 0 0 .824-2.207 6.815 6.815 0 0 1-.611-3.091c.076-3.59 1.42-6.182 4.116-7.906a10.643 10.643 0 0 1 5.459-1.508c5.609-.482 10.957 2.442 13.548 7.408 1.583 2.7 1.998 5.737 2.184 9.478 0 .489-.088.977-.12 1.454-.099 1.15-.186 2.234-.339 3.308a19.932 19.932 0 0 1-2.806 8.22c-2.85 4.339-6.375 6.508-10.764 6.508h-.874a7.848 7.848 0 0 1-5.83-2.755c-1.746-2.071-2.587-5.238.284-7.906a1.662 1.662 0 0 0-.016-2.267 1.69 1.69 0 0 0-2.276-.163A8.652 8.652 0 0 0 53.08 44a9.562 9.562 0 0 0 2.292 6.02 11.142 11.142 0 0 0 8.2 3.947l1.102.033z\"><\/path><path fill=\"#2098D5\" d=\"M50.532 35.62c2.727-3.29 6.761-5.023 10.006-6.153.38-.85.856-1.656 1.42-2.403a6.616 6.616 0 0 1-1.532-1.865l-1.465-2.5a1.072 1.072 0 0 1-.135-.853c.077-.29.272-.537.54-.683.263-.158.58-.203.879-.127.298.077.55.27.699.532l1.499 2.49c.222.437.503.842.834 1.207a6.504 6.504 0 0 0 1.126-2.358c.128-.606.736-.997 1.358-.872a1.12 1.12 0 0 1 .896 1.321 11.553 11.553 0 0 1-2.321 4.388 13.221 13.221 0 0 0-1.657 2.534 4.41 4.41 0 0 0-.202.538 4.024 4.024 0 0 0-.203 1.338c.023.743.24 1.468.63 2.106a8.883 8.883 0 0 0 2.683 2.732l4.417-1.997 1.51-.416c.622-.17 1.268.184 1.442.79a1.136 1.136 0 0 1-.811 1.404l-1.34.373-2.784 1.25c.906.427 1.853.765 2.828 1.01.294.064.549.242.708.491.159.25.208.55.137.836a1.122 1.122 0 0 1-1.127.844c-.093.011-.188.011-.281 0a19.036 19.036 0 0 1-5.128-2.194 1.13 1.13 0 0 1-.664-.416 11.331 11.331 0 0 1-3.573-3.599 6.47 6.47 0 0 1-.845-2.281 16.935 16.935 0 0 0-6.952 4.552c-3.313 3.993-3.088 9.763-2.322 13.899.372 1.996.913 4.015 1.431 5.978a54.344 54.344 0 0 1 1.95 9.742 27.936 27.936 0 0 1-.642 8.468c-.165.738-.836 1.264-1.612 1.262a1.435 1.435 0 0 1-.372 0 1.646 1.646 0 0 1-1.06-.708 1.566 1.566 0 0 1-.213-1.234c.575-2.474.765-5.018.563-7.547a51.605 51.605 0 0 0-1.859-9.182c-.53-2.018-1.127-4.091-1.476-6.198-.868-4.804-1.07-11.562 3.02-16.498z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tAdultes\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tDes calculs r\u00e9currents et\/ou inhabituels* peuvent \u00eatre des signaux d\u2019alerte.<sup>1,6\u20139<\/sup><br><br>\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0d49b23 e-con-full e-flex e-con e-child\" data-id=\"0d49b23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d9703b3 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"d9703b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" width=\"60\" height=\"62\" viewBox=\"0 0 60 62\"><g fill=\"none\" fill-rule=\"evenodd\"><g fill-rule=\"nonzero\"><g><g><g><path fill=\"#1E2656\" d=\"M33.13 34.296c.27-.123.562-.222.87-.296H10v1h21.595c.487-.258 1-.493 1.536-.704zM39.598 26.516c.137-.183.275-.334.402-.516H9v1h30.255c.155-.148.27-.312.343-.484z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><path fill=\"#1E2656\" d=\"M49.808 39.418V56.46c0 .742-.711 2.166-1.874 2.146H5.364c-.567.006-1.113-.22-1.514-.628-.402-.407-.625-.961-.62-1.537l-.058-38.072h16.68V3.385l26.62.097c2.442-.117 3.26.615 3.317 2.624v9.52c1.327-.809 2.278-.555 3.211-.975V4.897C52.394 2.595 51.385.02 46.01.166L19.286 0H16.92L0 15.441v40.97C0 59.035 2.403 62 5 62l42.645-.176c1.42.01 2.785-.556 3.791-1.573 1.006-1.017 1.57-2.4 1.564-3.84V38.579c-.308.137-2.346.634-3.192.84zM16.92 4.068V15.44H3.932L16.92 4.068z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><path fill=\"#1E2656\" d=\"M27 43H10v1h16.272c.22-.342.463-.676.728-1z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><path fill=\"#2098D5\" d=\"M58.628 21.564l-.667-.069-.067.674c-.136 1.211-.382 2.408-.735 3.574L52.135 21.7c1.036-.593 2.122-1.09 3.247-1.484l.599-.205-.6-2.011-.608.195c-2.594.956-5.011 2.346-7.15 4.11-.846.718-1.631 1.505-2.348 2.354-.84 1.008-1.514 2.145-2 3.368-1 2.499-1.236 5.244-.676 7.88-2.677.019-5.29.837-7.507 2.353-1.065.752-2.012 1.66-2.812 2.694-.691.855-1.296 1.777-1.807 2.754-1.249 2.465-2.063 5.131-2.405 7.879L28 52.26l1.41.136.667.069.068-.674c.14-1.188.386-2.362.734-3.505l4.937 4.013c-1.027.58-2.1 1.073-3.207 1.474l-.6.205.667 2.021.6-.205c2.595-.954 5.015-2.34 7.159-4.1.86-.704 1.659-1.481 2.386-2.324.815-1.014 1.467-2.151 1.933-3.369.997-2.5 1.23-5.245.666-7.88 2.67-.028 5.273-.846 7.488-2.352 1.062-.755 2.01-1.663 2.812-2.695.694-.856 1.3-1.782 1.807-2.763 1.252-2.46 2.066-5.124 2.405-7.87L60 21.77l-1.372-.205zm-19.469 28.47c-.463.41-.966.742-1.4 1.084l-6.088-4.882c.203-.537.474-1.074.735-1.679.203-.332.338-.674.54-.976l6.977 5.584c-.217.322-.474.614-.764.87zm2.145-2.216l-7.178-5.79c.612-.777 1.335-1.458 2.145-2.02l6.55 5.32c-.406.888-.916 1.724-1.517 2.49zm2.136-4.579l-5.45-4.374c1.659-.75 3.472-1.085 5.285-.977.482 1.744.539 3.58.165 5.351zm1.41-7.274c-.434-1.74-.467-3.557-.096-5.311l5.352 4.305c-1.644.766-3.449 1.112-5.256 1.006zm7.024-2.08l-6.56-5.32c.402-.882.897-1.717 1.478-2.49l7.15 5.79c-.567.79-1.267 1.474-2.068 2.02zm3.865-4.647l-.599.976-7.024-5.653c.274-.284.565-.55.87-.8.463-.41.966-.743 1.4-1.084l6.087 4.882c-.207.574-.449 1.135-.724 1.679h-.01z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tD\u00e9pistage\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tUn test de d\u00e9pistage dans les urines de 24 heures peut \u00eatre utilis\u00e9 pour aider \u00e0 d\u00e9tecter une maladie lithiasique m\u00e9tabolique.<sup>10\u201312<\/sup>\n\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d1dcbef e-flex e-con-boxed e-con e-parent\" data-id=\"d1dcbef\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-89ef038 elementor-widget elementor-widget-text-editor\" data-id=\"89ef038\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size:16px;\">*Y compris les calculs multiples, bilat\u00e9raux et\/ou de grande taille.<\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-145f4ba elementor-align-center elementor-widget elementor-widget-button\" data-id=\"145f4ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/depistage-de-lhp1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">D\u00e9pistage de l\u2019HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1db4af6 e-flex e-con-boxed e-con e-parent\" data-id=\"1db4af6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2e7b831 e-con-full e-flex e-con e-child\" data-id=\"2e7b831\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0342f95 elementor-widget elementor-widget-heading\" data-id=\"0342f95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">L\u2019HP1 EST UNE MALADIE H\u00c9R\u00c9DITAIRE RARE, PROGRESSIVE ET POTENTIELLEMENT MORTELLE.<sup>3,4<\/sup><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-53d81f0 e-con-full e-flex e-con e-child\" data-id=\"53d81f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fbc7d69 elementor-widget elementor-widget-image\" data-id=\"fbc7d69\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"492\" height=\"264\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/primary-hyperoxaluria-type-1-mechanism-of-disease.png\" class=\"attachment-large size-large wp-image-6961\" alt=\"Hyperoxalurie primitive de type\u00a01 (HP1) - M\u00e9canisme de la maladie - Interaction foie-rein\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/primary-hyperoxaluria-type-1-mechanism-of-disease.png 492w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/primary-hyperoxaluria-type-1-mechanism-of-disease-300x161.png 300w\" sizes=\"(max-width: 492px) 100vw, 492px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f496017 e-con-full e-flex e-con e-child\" data-id=\"f496017\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-79642b8 elementor-widget elementor-widget-text-editor\" data-id=\"79642b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019HP1 est due \u00e0 des mutations autosomiques r\u00e9cessives du g\u00e8ne <em>AGXT<\/em>, qui entra\u00eenent une surproduction d\u2019oxalate dans le foie.<sup>3,4<\/sup> Avec le temps, la surproduction d\u2019oxalate peut entra\u00eener un d\u00e9clin progressif de la fonction r\u00e9nale.<sup>2,4<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-070b5b0 elementor-align-left elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"070b5b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/decouvrir-lhp1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">D\u00e9couvrir l\u2019HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dcc5ba1 e-flex e-con-boxed e-con e-parent\" data-id=\"dcc5ba1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2bf4788 e-con-full e-flex e-con e-child\" data-id=\"2bf4788\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f989eb elementor-widget elementor-widget-heading\" data-id=\"8f989eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">LA SUSPICION D\u2019HP1 DOIT \u00caTRE FORTE CHEZ LES PATIENTS NON DIAGNOSTIQU\u00c9S PR\u00c9SENTANT DES SIGNES D\u2019ALERTE S\u2019ILS SONT ORIGINAIRES DE R\u00c9GIONS O\u00d9 LES CAS D\u2019HP1 SONT PLUS FR\u00c9QUENTS<sup>13<\/sup><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bb9e988 e-con-full e-flex e-con e-child\" data-id=\"bb9e988\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f2dfcf6 elementor-widget elementor-widget-text-editor\" data-id=\"f2dfcf6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Les publications scientifiques indiquent une pr\u00e9valence d\u2019HP1 sup\u00e9rieure \u00e0 la moyenne dans les populations suivantes :<sup>13<\/sup><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bac063e elementor-widget elementor-widget-image\" data-id=\"bac063e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"453\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-fr-1024x580.jpg\" class=\"attachment-large size-large wp-image-8310\" alt=\"Carte de pr\u00e9valence de PH1\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-fr-1024x580.jpg 1024w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-fr-300x170.jpg 300w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-fr-768x435.jpg 768w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-fr.jpg 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d77517a e-con-full e-flex e-con e-child\" data-id=\"d77517a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1389ecf elementor-widget elementor-widget-text-editor\" data-id=\"1389ecf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Regardez la vid\u00e9o du Dr Moochhala qui explique dans quelle mesure la consanguinit\u00e9 peut augmenter le risque d\u2019HP1 et pourquoi cet \u00e9l\u00e9ment est important lors de l\u2019\u00e9valuation de patients pr\u00e9sentant des calculs r\u00e9naux inexpliqu\u00e9s.<\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7186d76 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"7186d76\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/dr-shabbir-moochhala-fr.jpg&quot;,&quot;id&quot;:8751,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Dr. Moochhala KOL video&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1143806176?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/dr-shabbir-moochhala-fr.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Dr. Moochhala KOL video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-db58228 e-flex e-con-boxed e-con e-parent\" data-id=\"db58228\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d156e46 e-con-full e-flex e-con e-child\" data-id=\"d156e46\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-72c132f elementor-widget elementor-widget-heading\" data-id=\"72c132f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">HP1 : SOUS-DIAGNOSTIQU\u00c9E ET DIAGNOSTIC RETARD\u00c9<sup>8,14\u201317<\/sup><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3fb2253 elementor-widget elementor-widget-heading\" data-id=\"3fb2253\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Le diagnostic est souvent retard\u00e9 lorsque l\u2019HP1 n\u2019est pas d\u00e9tect\u00e9e<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe75b96 e-con-full e-flex e-con e-child\" data-id=\"fe75b96\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-661d014 elementor-widget elementor-widget-eael-progress-bar\" data-id=\"661d014\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-progress-bar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-progressbar-circle-container center\">\n                \n            \n                <div class=\"eael-progressbar eael-progressbar-circle\" data-layout=\"circle\" data-count=\"50\" data-duration=\"1500\">\n                    <div class=\"eael-progressbar-circle-pie\">\n                        <div class=\"eael-progressbar-circle-half-left eael-progressbar-circle-half\"><\/div>\n                        <div class=\"eael-progressbar-circle-half-right eael-progressbar-circle-half\"><\/div>\n                    <\/div>\n                    <div class=\"eael-progressbar-circle-inner\"><\/div>\n                    <div class=\"eael-progressbar-circle-inner-content\">\n                        <div class=\"eael-progressbar-title\">~<\/div>\n                        <span class=\"eael-progressbar-count-wrap\"><span class=\"eael-progressbar-count\">0<\/span><span class=\"postfix\">%<\/span><\/span>\n                    <\/div>\n                <\/div>\n\n                \n            <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec1ae0e elementor-widget elementor-widget-text-editor\" data-id=\"ec1ae0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>des patients atteints d\u2019HP1 pourraient \u00eatre sous-diagnostiqu\u00e9s, bien que les donn\u00e9es relatives \u00e0 la pr\u00e9valence soient limit\u00e9es.<sup>17<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ab77764 e-con-full e-flex e-con e-child\" data-id=\"ab77764\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-60f9104 elementor-widget elementor-widget-eael-progress-bar\" data-id=\"60f9104\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-progress-bar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-progressbar-circle-container center\">\n                \n            \n                <div class=\"eael-progressbar eael-progressbar-circle\" data-layout=\"circle\" data-count=\"55\" data-duration=\"1500\">\n                    <div class=\"eael-progressbar-circle-pie\">\n                        <div class=\"eael-progressbar-circle-half-left eael-progressbar-circle-half\"><\/div>\n                        <div class=\"eael-progressbar-circle-half-right eael-progressbar-circle-half\"><\/div>\n                    <\/div>\n                    <div class=\"eael-progressbar-circle-inner\"><\/div>\n                    <div class=\"eael-progressbar-circle-inner-content\">\n                        <span class=\"eael-progressbar-title\">5,5 <br><span>ANS<\/span><\/span>\n                        <span class=\"eael-progressbar-count-wrap\" style=\"display: none;\"><span class=\"eael-progressbar-count\">0<\/span><span class=\"postfix\">%<\/span><\/span>\n                    <\/div>\n                <\/div>\n\n                \n            <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aac8e2c elementor-widget elementor-widget-text-editor\" data-id=\"aac8e2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>est le d\u00e9lai m\u00e9dian chez l\u2019adulte entre l\u2019apparition des manifestations cliniques et le diagnostic.<sup>15<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f6f2a07 e-con-full e-flex e-con e-child\" data-id=\"f6f2a07\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0d5b48a elementor-widget elementor-widget-eael-progress-bar\" data-id=\"0d5b48a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-progress-bar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-progressbar-circle-container center\">\n                \n            \n                <div class=\"eael-progressbar eael-progressbar-circle\" data-layout=\"circle\" data-count=\"70\" data-duration=\"1500\">\n                    <div class=\"eael-progressbar-circle-pie\">\n                        <div class=\"eael-progressbar-circle-half-left eael-progressbar-circle-half\"><\/div>\n                        <div class=\"eael-progressbar-circle-half-right eael-progressbar-circle-half\"><\/div>\n                    <\/div>\n                    <div class=\"eael-progressbar-circle-inner\"><\/div>\n                    <div class=\"eael-progressbar-circle-inner-content\">\n                        <div class=\"eael-progressbar-title\">JUSQU\u2019\u00c0<\/div>\n                        <span class=\"eael-progressbar-count-wrap\"><span class=\"eael-progressbar-count\">0<\/span><span class=\"postfix\">%<\/span><\/span>\n                    <\/div>\n                <\/div>\n\n                \n            <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-936becd elementor-widget elementor-widget-text-editor\" data-id=\"936becd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>des diagnostics chez l\u2019adulte sont pos\u00e9s apr\u00e8s l\u2019\u00e9volution en insuffisance r\u00e9nale terminale (IRT).<sup>14,18\u201321<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e8f799e e-flex e-con-boxed e-con e-parent\" data-id=\"e8f799e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ed6d46b e-con-full e-flex e-con e-child\" data-id=\"ed6d46b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5edec30 elementor-align-right elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"5edec30\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/connaitre-les-signes\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conna\u00eetre les signes<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-60b866c e-con-full e-flex e-con e-child\" data-id=\"60b866c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8490d00 elementor-align-left elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"8490d00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/downloads\/fr\/PH1-FRA-00009_Brochure_sur_lHP1.pdf\" target=\"_blank\" download=\"Brochure-sur-lHP1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"15\" viewBox=\"0 0 16 15\"><path fill=\"#D0191F\" fill-rule=\"evenodd\" d=\"M14.28 7.58a.5.5 0 0 1 1 0v4.825c0 .643-.263 1.227-.685 1.65a2.332 2.332 0 0 1-1.65.685H2.335a2.328 2.328 0 0 1-1.65-.685A2.324 2.324 0 0 1 0 12.405V7.58a.5.5 0 0 1 1 0v4.825a1.335 1.335 0 0 0 1.334 1.334h10.611a1.338 1.338 0 0 0 1.334-1.334V7.58zm-9.958-.854a.5.5 0 0 1 .707-.707l2.111 2.11V.5a.5.5 0 0 1 1 0v7.63l2.11-2.11a.5.5 0 0 1 .707.707l-2.96 2.96a.453.453 0 0 1-.032.03l-.018.015-.004.003-.008.006-.008.006-.005.004-.004.002-.006.005-.004.003-.006.003-.008.005a.508.508 0 0 1-.508 0l-.009-.005-.004-.003-.004-.003-.008-.005-.002-.002-.006-.004-.008-.006h-.002l-.005-.006-.004-.003a.173.173 0 0 1-.02-.014c-.012-.01-.02-.02-.03-.031l-2.962-2.96z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">T\u00e9l\u00e9charger la brochure sur l\u2019HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc5b474 e-flex e-con-boxed e-con e-parent\" data-id=\"cc5b474\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2bce96d e-con-full e-flex e-con e-child\" data-id=\"2bce96d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59e05f1 elementor-widget elementor-widget-heading\" data-id=\"59e05f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">S\u2019inscrire pour recevoir plus d\u2019informations sur l\u2019HP1<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-48656ef elementor-mobile-align-center elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"48656ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Restons en contact<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1f2359f e-con-full e-flex e-con e-child\" data-id=\"1f2359f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8a20469 elementor-widget elementor-widget-image\" data-id=\"8a20469\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/laptop-icon.png\" class=\"attachment-large size-large wp-image-6938\" alt=\"Ic\u00f4ne Ordinateur portable\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/laptop-icon.png 300w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/laptop-icon-150x150.png 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-44b788d e-flex e-con-boxed e-con e-parent\" data-id=\"44b788d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dfd856 elementor-widget elementor-widget-heading\" data-id=\"5dfd856\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">APPROCHES DE PRISE EN CHARGE DE L\u2019HP1<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbbd4a9 elementor-widget elementor-widget-text-editor\" data-id=\"dbbd4a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLes approches actuelles de la prise en charge de l\u2019HP1 visent \u00e0 am\u00e9liorer la clairance de l\u2019oxalate, \u00e0 inhiber la cristallisation de l\u2019oxalate ou \u00e0 r\u00e9duire la production d\u2019oxalate par le foie.<sup>3,4,11<\/sup>\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6545417 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6545417\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/prise-en-charge\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Prise en charge<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4f49f3 e-flex e-con-boxed e-con e-parent\" data-id=\"f4f49f3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4e9530 elementor-hidden-tablet elementor-hidden-mobile elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b4e9530\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eeaccc0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"eeaccc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/decouvrir-lhp1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">\u00c0 LA <span>D\u00c9COUVERTE<br \/>DE L\u2019HP1<\/span><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9b32ca e-flex e-con-boxed e-con e-parent\" data-id=\"d9b32ca\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1fc7878 e-con-full e-flex e-con e-child\" data-id=\"1fc7878\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-260f8d2 elementor-widget elementor-widget-heading\" data-id=\"260f8d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Test de d\u00e9pistage de l\u2019HP1 chez les patients<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c10eae elementor-widget elementor-widget-text-editor\" data-id=\"1c10eae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e9couvrez le r\u00f4le important que jouent les tests g\u00e9n\u00e9tiques dans le diagnostic de l\u2019HP1.<sup>3,11<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4958985 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"4958985\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr\/depistage-de-lhp1\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Options de d\u00e9pistage<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64116a1 e-con-full e-flex e-con e-child\" data-id=\"64116a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a4e59d5 elementor-widget elementor-widget-heading\" data-id=\"a4e59d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Obtenir des mises \u00e0 jour<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b19f6b elementor-widget elementor-widget-text-editor\" data-id=\"9b19f6b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>S\u2019inscrire pour recevoir des informations d\u2019Alnylam sur l\u2019HP1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1a7586 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d1a7586\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">S\u2019inscrire<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d828f46 e-flex e-con-boxed e-con e-parent\" data-id=\"d828f46\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d27d09 elementor-widget elementor-widget-text-editor\" data-id=\"6d27d09\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"footer-refs\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>R\u00e9f\u00e9rences : 1.<\/strong> Ferraro PM, D\u2019Addessi A, Gambaro G. <em>Nephrol Dial Transplant.<\/em> 2013;28(4):811\u2013820. <strong>2.<\/strong> Hoppe B. <em>Nat Rev Nephrol.<\/em> 2012;8(8):467\u2013475. <strong>3.<\/strong> Milliner DS, Harris PC, Sas DJ, <em>et al.<\/em> Primary hyperoxaluria type 1. GeneReviews<sup>\u00ae<\/sup> [<em>Internet<\/em>]. Mis \u00e0 jour le 15 ao\u00fbt 2024. Dernier acc\u00e8s en janvier 2026. <strong>4.<\/strong> Cochat P, Rumsby G. <em>N Engl J Med.<\/em> 2013;369(7):649\u2013658. <strong>5.<\/strong> Hoppe B, Kemper MJ. <em>Pediatr Nephrol.<\/em> 2010;25(3):403\u2013413. <strong>6.<\/strong> Jendeberg J, Geijer H, Alshamari M, <em>et al. Eur Radiol.<\/em> 2017;27(11):4775\u20134785. <strong>7.<\/strong> Carrasco A Jr, Granberg CF, Gettman MT, <em>et al. Urology.<\/em> 2015;85(3):522\u2013526. <strong>8.<\/strong> Hoppe B, Beck BB, Milliner DS. <em>Kidney Int.<\/em> 2009;75(12):1264\u20131271. <strong>9.<\/strong> Leumann E, Hoppe B. <em>J Am Soc Nephrol.<\/em> 2001;12(9):1986\u20131993. <strong>10.<\/strong> Ben-Shalom E, Frishberg Y. <em>Pediatr Nephrol.<\/em> 2015;30(10):1781\u20131791. <strong>11.<\/strong> Cochat P, Hulton SA, Acquaviva C, <em>et al. Nephrol Dial Transplant.<\/em> 2012;27(5):1729\u20131736. <strong>12.<\/strong> Groothoff JW, Metry E, Deesker L, <em>et al. Nat Rev Nephrol.<\/em> 2023;19(3):194\u2013211. <strong>13.<\/strong> Mandrile G, Rumsby G, Sciannameo V, <em>et al. Clin Kidney J.<\/em> 2025;18(7):sfaf194. <strong>14.<\/strong> Harambat J, Fargue S, Acquaviva C, <em>et al. Kidney Int.<\/em> 2010;77(5):443\u2013449. <strong>15.<\/strong> van der Hoeven SM, van Woerden CS, Groothoff JW. <em>Nephrol Dial Transplant.<\/em> 2012;27(10):3855\u20133862. <strong>16.<\/strong> Hulton SA. <em>Int J Surg.<\/em> 2016;36(Pt D):649\u2013654. <strong>17.<\/strong> Hopp K, Cogal AG, Bergstralh EJ, <em>et al. J Am Soc Nephrol.<\/em> 2015;26(10):2559\u20132570. <strong>18.<\/strong> van Woerden CS, Groothoff JW, Wanders RJA, <em>et al. Nephrol Dial Transplant.<\/em> 2003;18(2):273\u2013279. <strong>19.<\/strong> Mandrile G, van Woerden CS, Berchialla P, <em>et al<\/em>; pour OxalEurope Consortium. <em>Kidney Int.<\/em> 2014;86(6):1197\u20131204. <strong>20.<\/strong> Lieske JC, Monico CG, Holmes WS, <em>et al. Am J Nephrol.<\/em> 2005;25(3):290\u2013296. <strong>21.<\/strong> Soliman NA, Nabhan MM, Abdelrahman SM, <em>et al. Nephrol Ther.<\/em> 2017;13(3):176\u2013182.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8a8bb8 elementor-widget elementor-widget-text-editor\" data-id=\"f8a8bb8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<section id=\"block-footerhomereferences\" class=\"block block-block-content block-block-contentead207f3-e885-4e6e-bd3b-f06ef2b5be1d clearfix\"><div class=\"field field--name-body field--type-text-with-summary field--label-hidden field--item\"><div class=\"container\"><div class=\"container-970\"><p class=\"references\">PH1-FRA-00145 I F\u00e9vrier 2026<\/p><\/div><\/div><\/div><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>L\u2019hyperoxalurie primitive de type 1 (HP1) est une maladie h\u00e9r\u00e9ditaire rare et progressive qui peut entra\u00eener un d\u00e9clin de la fonction r\u00e9nale. D\u00e9couvrez les manifestations de l\u2019HP1. <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-6863","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages\/6863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/comments?post=6863"}],"version-history":[{"count":123,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages\/6863\/revisions"}],"predecessor-version":[{"id":8899,"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/pages\/6863\/revisions\/8899"}],"wp:attachment":[{"href":"https:\/\/www.thinkph1.eu\/fr\/wp-json\/wp\/v2\/media?parent=6863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}