{"id":4521,"date":"2024-06-03T13:57:32","date_gmt":"2024-06-03T13:57:32","guid":{"rendered":"https:\/\/www.thinkph1.eu\/?page_id=4521"},"modified":"2026-01-16T11:55:58","modified_gmt":"2026-01-16T11:55:58","slug":"descubrir-la-hp1","status":"publish","type":"page","link":"https:\/\/www.thinkph1.eu\/es\/descubrir-la-hp1\/","title":{"rendered":"Sobre la hiperoxaluria primaria de tipo 1 (HP1) | Think PH1\u2122"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4521\" class=\"elementor elementor-4521 elementor-25\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ed2ef5 e-flex e-con-boxed e-con e-parent\" data-id=\"5ed2ef5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e826260 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"e826260\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RESUMEN DE LA HIPEROXALURIA PRIMARIA DE TIPO 1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7956335 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7956335\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La hiperoxaluria primaria de tipo 1 (HP1) es una enfermedad metab\u00f3lica hereditaria, rara y progresiva, asociada a litiasis y potencialmente mortal, con presencia frecuente de c\u00e1lculos renales.<sup>1\u20133<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64ae249 e-flex e-con-boxed e-con e-parent\" data-id=\"64ae249\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b558f28 e-flex e-con-boxed e-con e-child\" data-id=\"b558f28\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d80e7aa elementor-widget elementor-widget-heading\" data-id=\"d80e7aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LA HP1 ES UNA ENFERMEDAD METAB\u00d3LICA RARA, HEREDITARIA Y PROGRESIVA<sup>1\u20133<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c341bcb elementor-widget elementor-widget-text-editor\" data-id=\"c341bcb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Las hiperoxalurias primarias (HP) son un grupo de enfermedades metab\u00f3licas autos\u00f3micas recesivas asociadas a la litiasis, causadas por defectos en diferentes enzimas implicadas en el metabolismo del glioxilato que dan lugar a una hiperproducci\u00f3n de oxalato en el h\u00edgado.<sup>2,3 <\/sup>Hay 3 tipos diferentes de HP: HP1, HP2 y HP3. Cada una es causada por un defecto en una enzima distinta.<sup>3<\/sup><\/p><p>La HP1 se suele presentar con c\u00e1lculos renales y est\u00e1 causada por mutaciones autos\u00f3micas recesivas en el gen <em>AGXT<\/em>, que alteran la funci\u00f3n de la enzima espec\u00edfica del h\u00edgado alanina:glioxilato aminotransferasa (AGT).<sup>1,3<\/sup> Normalmente, la AGT procesa el glioxilato, que es generado por otra enzima hep\u00e1tica, glicolato oxidasa (GO).<sup>2,3<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3de7280 elementor-widget elementor-widget-text-editor\" data-id=\"3de7280\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Escuche al Dr. Moochhala hablar sobre la relaci\u00f3n entre la consanguinidad y el riesgo de HP1<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f18a378 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"f18a378\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/dr-shabbir-moochhala-es.jpg&quot;,&quot;id&quot;:8753,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Dr. Moochhala KOL video&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1143804572?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/dr-shabbir-moochhala-es.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Dr. Moochhala KOL video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3bc47ce elementor-widget elementor-widget-text-editor\" data-id=\"3bc47ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00bfTiene en cuenta la consanguinidad al evaluar a pacientes con c\u00e1lculos renales? Descubra por qu\u00e9 es importante al evaluar a pacientes con c\u00e1lculos renales de causa desconocida.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01572db elementor-widget elementor-widget-n-accordion\" data-id=\"01572db\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1400\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1400\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Lea aqu\u00ed la transcripci\u00f3n completa <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"icon icon-up-arrow1\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"icon icon-down-arrow1\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1400\" class=\"elementor-element elementor-element-d5397c6 e-con-full e-flex e-con e-child\" data-id=\"d5397c6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3e6be4 elementor-widget elementor-widget-text-editor\" data-id=\"f3e6be4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dr. Moochhala: HP1 es una abreviatura. Quiere decir hiperoxaluria primaria de tipo 1. Primaria significa que es una enfermedad gen\u00e9tica. Hiperoxaluria significa que hay un exceso de oxalato en la orina. El oxalato es un producto residual. Y el tipo 1 nos indica que una enzima concreta tiene un defecto. Hay una elevada cantidad de efectos da\u00f1inos en la hiperproducci\u00f3n de oxalato en el organismo. En primer lugar, el oxalato se deposita en los ri\u00f1ones, lo que causa c\u00e1lculos renales, pero tambi\u00e9n la calcificaci\u00f3n de los propios ri\u00f1ones.<\/p><p>Tambi\u00e9n se puede depositar en cualquiera de los tejidos blandos. Es decir, la piel, los ojos, el coraz\u00f3n, los m\u00fasculos: cualquier tejido blando. Y la sedimentaci\u00f3n es permanente, por lo que puede reducir la funci\u00f3n de dicho tejido. Y por ello es una enfermedad progresiva tan peligrosa, que queremos tratar lo antes posible. Muy a menudo el \u00fanico s\u00edntoma puede ser que el paciente tenga c\u00e1lculos renales durante un periodo de tiempo. Es una enfermedad muy rara y por eso es tan dif\u00edcil de diagnosticar.<\/p><p>Aunque seguimos pistas como el historial familiar. S\u00ed que observamos que emergen algunos patrones iniciales, uno de ellos es que vemos una mayor prevalencia de HP1 en pacientes de determinadas procedencias, y que pueden incluir el sudeste asi\u00e1tico, Oriente Medio y el norte de \u00c1frica. Mi mensaje a los m\u00e9dicos de todo el mundo que visitan pacientes para diagnosticar enfermedades raras es que piensen: si tienen c\u00e1lculos renales, \u00ab\u00bfQu\u00e9 ha causado el c\u00e1lculo?\u00bb. Creo que es lo mismo que har\u00edamos para cualquier otra enfermedad o cuadro cl\u00ednico, nos preguntar\u00edamos, bueno, \u00ab\u00bfCu\u00e1l es el motivo?\u00bb. Deber\u00edamos hacer lo mismo para pacientes que forman c\u00e1lculos renales. Deber\u00edamos cuestionarnos: \u00abHa tenido varios c\u00e1lculos renales durante un periodo de tiempo. \u00bfPor qu\u00e9?\u00bb. \u00ab\u00bfHemos reflexionado sobre la causa?\u00bb. \u00ab\u00bfLa hemos investigado?\u00bb. \u00ab\u00bfLe hemos derivado a alguien que pueda analizarlo con mayor detalle?\u00bb. Porque esta es la forma en la que haremos diagn\u00f3sticos, no solo de enfermedades comunes, sino tambi\u00e9n de enfermedades raras. Si cree que observa algo inusual, como un paciente que tiene un poco de insuficiencia renal, pero cuyo historial familiar muestra indicios claros de que sucede algo, o hay una cantidad inusual de formaci\u00f3n de c\u00e1lculos renales en un paciente joven, derive al paciente a un nefr\u00f3logo. El diagn\u00f3stico temprano es absolutamente esencial para la HP1. Cuanto antes pueda empezar a estabilizar la funci\u00f3n renal del paciente, con suerte reducir\u00e1 e incluso prevendr\u00e1 que siga formando c\u00e1lculos renales. Sea perseverante. Si cree que existe un problema, es mejor examinar al paciente y concluir que est\u00e1 todo bien antes que pasar por alto a alguien que pueda tener una enfermedad rara como la HP1 o enfermedades raras que forman c\u00e1lculos renales. As\u00ed que mi mensaje es que sea perseverante.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fee24f6 e-flex e-con-boxed e-con e-parent\" data-id=\"fee24f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3946a00 e-con-full e-flex e-con e-child\" data-id=\"3946a00\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-873fbc6 elementor-widget elementor-widget-heading\" data-id=\"873fbc6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">EL DIAGN\u00d3STICO TEMPRANO DE LA HP1 PUEDE AYUDAR A ATENUAR EL DA\u00d1O RENAL<sup>2\u20136<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f3883e0 e-grid e-con-boxed e-con e-child\" data-id=\"f3883e0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3757ec8 e-con-full e-flex e-con e-child\" data-id=\"3757ec8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b9e8c43 elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"b9e8c43\" data-element_type=\"widget\" data-e-type=\"widget\" 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transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000)\"><\/path><g><path d=\"M18.3 1.4c-.4-.4-.9-.5-1.5-.5-1.1.1-2 1.1-1.9 2.2v1.2h-.2H1.3C.6 4.3 0 4.9 0 5.6c0 .7.6 1.3 1.3 1.3h13.4l-.1.3c-.7 2.4-2.3 4.6-4.9 6.6-.9.7-1 2-.4 2.9.4.5 1 .8 1.6.8.5 0 .9-.2 1.3-.4 5-3.9 7.3-8.6 6.9-14.2-.1-.7-.4-1.2-.8-1.5z\" fill=\"#1F2756\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000) translate(10.000000, 0.000000)\"><\/path><path d=\"M12.1 16.9c-.4.3-.8.4-1.3.4-.6 0-1.2-.3-1.6-.8-.7-.9-.5-2.2.4-2.9 2.6-2 4.2-4.2 4.9-6.6l.1-.3H1.3C.6 6.7 0 6.1 0 5.4c0-.7.6-1.3 1.3-1.3h13.6L15 4v-.9C14.9 2 15.8 1 16.9.9c.5 0 1.1.1 1.5.5.3.3.6.8.6 1.4.4 5.6-1.8 10.2-6.9 14.1z\" fill=\"#062059\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000) translate(10.000000, 0.000000)\"><\/path><\/g><path d=\"M19 60H6.2l.1-.3c.6-2.6 2.3-5 5.1-7.2.9-.7 1-2 .4-2.9-.3-.4-.8-.7-1.4-.8h-.3c-.5 0-.9.2-1.3.4-5 3.9-7.3 8.6-6.9 14.2.1 1.1 1.1 2 2.2 1.9.5 0 1-.3 1.4-.7.4-.4.5-.9.5-1.5V62.5h13c.7 0 1.3-.6 1.3-1.3 0-.6-.6-1.2-1.3-1.2z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -62.000000) translate(75.000000, 62.000000) translate(29.000000, 11.000000)\"><\/path><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tLa HP1 es el tipo m\u00e1s com\u00fan (y m\u00e1s grave) de HP<sup>1,3,7<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fc0894 elementor-widget elementor-widget-text-editor\" data-id=\"8fc0894\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tEntre el 70 % y el 80 % de los casos de HP son HP1. A pesar de ello, se trata de una enfermedad infrecuente, que afecta aproximadamente de 1 a 3 casos por cada mill\u00f3n de poblaci\u00f3n, con una tasa de incidencia de 1 caso por cada 120 000 nacimientos vivos al a\u00f1o en Europa y con una mayor prevalencia en Oriente Medio y \u00c1frica del Norte.<sup>1,3,7<\/sup> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c059fa3 e-con-full e-flex e-con e-child\" data-id=\"c059fa3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-87bac69 elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"87bac69\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"88\" height=\"88\" viewBox=\"0 0 88 88\"><g fill=\"none\" fill-rule=\"nonzero\"><path fill=\"#1E2656\" d=\"M23.362 54c-5.525 0-10.079-2.679-13.562-7.982a22.931 22.931 0 0 1-3.276-9.555c-.207-1.182-.306-2.375-.393-3.514L6 31.419v-.205c.11-3.45.459-7.451 2.577-11.139 3.702-6.312 9.27-9.349 16.576-9.056 2.543.014 5.034.715 7.207 2.028 3.647 2.343 5.547 5.922 5.634 10.64a10.146 10.146 0 0 1-.906 4.544 1.68 1.68 0 0 1-2.89.27 1.655 1.655 0 0 1-.157-1.658c.443-.97.652-2.028.612-3.091-.077-3.59-1.42-6.182-4.117-7.906a10.647 10.647 0 0 0-5.514-1.508c-5.61-.482-10.96 2.442-13.551 7.408-1.584 2.7-1.999 5.704-2.13 9.478 0 .489.088.977.12 1.454.099 1.15.186 2.234.339 3.308a19.93 19.93 0 0 0 2.806 8.22c2.85 4.339 6.377 6.508 10.767 6.508h.874a7.85 7.85 0 0 0 5.83-2.755c1.748-2.071 2.589-5.238-.283-7.906a1.664 1.664 0 0 1 .605-2.916 1.689 1.689 0 0 1 1.688.486A8.651 8.651 0 0 1 35.013 44a9.562 9.562 0 0 1-2.347 6.02 11.145 11.145 0 0 1-8.201 3.947L23.362 54z\"><\/path><path fill=\"#2098D5\" d=\"M37.468 35.62c-2.727-3.29-6.761-5.023-10.007-6.153a12.252 12.252 0 0 0-1.42-2.403 6.616 6.616 0 0 0 1.533-1.865l1.499-2.5c.162-.255.21-.563.134-.853a1.101 1.101 0 0 0-.54-.683 1.153 1.153 0 0 0-.878-.127c-.298.077-.55.27-.7.532l-1.532 2.49a5.544 5.544 0 0 1-.834 1.207 6.504 6.504 0 0 1-1.127-2.358 1.13 1.13 0 0 0-.763-.838c-.39-.126-.82-.04-1.127.225-.307.266-.446.67-.363 1.062a11.553 11.553 0 0 0 2.32 4.388c.65.781 1.206 1.631 1.657 2.534.08.175.147.355.203.538.143.432.212.884.203 1.338a4.302 4.302 0 0 1-.63 2.106 8.883 8.883 0 0 1-2.683 2.732l-4.417-1.997-1.51-.416a1.193 1.193 0 0 0-1.134.282 1.12 1.12 0 0 0-.315 1.097c.103.394.415.705.818.815l1.34.373 2.784 1.25c-.906.427-1.854.765-2.828 1.01a1.126 1.126 0 0 0-.708.491c-.159.25-.208.55-.138.836.123.506.594.858 1.127.844.094.011.188.011.282 0a19.037 19.037 0 0 0 5.127-2.194 1.13 1.13 0 0 0 .665-.416 11.331 11.331 0 0 0 3.572-3.599 6.47 6.47 0 0 0 .846-2.281 16.935 16.935 0 0 1 6.952 4.552c3.313 3.993 3.088 9.763 2.322 13.899-.372 1.996-.913 4.015-1.431 5.978a54.344 54.344 0 0 0-1.95 9.742 27.935 27.935 0 0 0 .642 8.468c.165.738.836 1.264 1.612 1.262.123.016.248.016.372 0 .437-.086.82-.342 1.06-.708.24-.366.317-.811.213-1.234a24.644 24.644 0 0 1-.563-7.547c.34-3.108.961-6.18 1.859-9.182.53-2.018 1.127-4.091 1.476-6.198.868-4.804 1.07-11.562-3.02-16.498z\"><\/path><path fill=\"#1E2656\" d=\"M64.674 54c5.524 0 10.077-2.679 13.56-7.982a22.934 22.934 0 0 0 3.275-9.555c.174-1.182.273-2.375.36-3.514l.131-1.53v-.205c-.12-3.45-.426-7.451-2.587-11.139-3.701-6.312-9.27-9.349-16.573-9.056a14.076 14.076 0 0 0-7.206 2.028c-3.646 2.343-5.546 5.922-5.633 10.64a10.15 10.15 0 0 0 1.004 4.544 1.68 1.68 0 0 0 2.222.819 1.66 1.66 0 0 0 .824-2.207 6.815 6.815 0 0 1-.611-3.091c.076-3.59 1.42-6.182 4.116-7.906a10.643 10.643 0 0 1 5.459-1.508c5.609-.482 10.957 2.442 13.548 7.408 1.583 2.7 1.998 5.737 2.184 9.478 0 .489-.088.977-.12 1.454-.099 1.15-.186 2.234-.339 3.308a19.932 19.932 0 0 1-2.806 8.22c-2.85 4.339-6.375 6.508-10.764 6.508h-.874a7.848 7.848 0 0 1-5.83-2.755c-1.746-2.071-2.587-5.238.284-7.906a1.662 1.662 0 0 0-.016-2.267 1.69 1.69 0 0 0-2.276-.163A8.652 8.652 0 0 0 53.08 44a9.562 9.562 0 0 0 2.292 6.02 11.142 11.142 0 0 0 8.2 3.947l1.102.033z\"><\/path><path fill=\"#2098D5\" d=\"M50.532 35.62c2.727-3.29 6.761-5.023 10.006-6.153.38-.85.856-1.656 1.42-2.403a6.616 6.616 0 0 1-1.532-1.865l-1.465-2.5a1.072 1.072 0 0 1-.135-.853c.077-.29.272-.537.54-.683.263-.158.58-.203.879-.127.298.077.55.27.699.532l1.499 2.49c.222.437.503.842.834 1.207a6.504 6.504 0 0 0 1.126-2.358c.128-.606.736-.997 1.358-.872a1.12 1.12 0 0 1 .896 1.321 11.553 11.553 0 0 1-2.321 4.388 13.221 13.221 0 0 0-1.657 2.534 4.41 4.41 0 0 0-.202.538 4.024 4.024 0 0 0-.203 1.338c.023.743.24 1.468.63 2.106a8.883 8.883 0 0 0 2.683 2.732l4.417-1.997 1.51-.416c.622-.17 1.268.184 1.442.79a1.136 1.136 0 0 1-.811 1.404l-1.34.373-2.784 1.25c.906.427 1.853.765 2.828 1.01.294.064.549.242.708.491.159.25.208.55.137.836a1.122 1.122 0 0 1-1.127.844c-.093.011-.188.011-.281 0a19.036 19.036 0 0 1-5.128-2.194 1.13 1.13 0 0 1-.664-.416 11.331 11.331 0 0 1-3.573-3.599 6.47 6.47 0 0 1-.845-2.281 16.935 16.935 0 0 0-6.952 4.552c-3.313 3.993-3.088 9.763-2.322 13.899.372 1.996.913 4.015 1.431 5.978a54.344 54.344 0 0 1 1.95 9.742 27.936 27.936 0 0 1-.642 8.468c-.165.738-.836 1.264-1.612 1.262a1.435 1.435 0 0 1-.372 0 1.646 1.646 0 0 1-1.06-.708 1.566 1.566 0 0 1-.213-1.234c.575-2.474.765-5.018.563-7.547a51.605 51.605 0 0 0-1.859-9.182c-.53-2.018-1.127-4.091-1.476-6.198-.868-4.804-1.07-11.562 3.02-16.498z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tLa HP1 puede provocar un da\u00f1o renal irreparable<sup>1,3<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fbbf52 elementor-widget elementor-widget-text-editor\" data-id=\"4fbbf52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tUno de los aspectos m\u00e1s devastadores de la HP1 es que causa un deterioro progresivo de la funci\u00f3n renal que culmina en enfermedad renal terminal (ERT).<sup>1,3,6<\/sup> Adem\u00e1s, hay un riesgo potencial de oxalosis sist\u00e9mica.<sup>3,8<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-44cdeaa e-con-full e-flex e-con e-child\" data-id=\"44cdeaa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb0223d elementor-tablet-position-inline-start elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"cb0223d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" height=\"88\" viewBox=\"0 0 88 88\" width=\"88\"><g fill=\"none\" fill-rule=\"evenodd\"><g fill-rule=\"nonzero\"><g><g><g><path d=\"M1.2 47.1c0 .3-.7 5.5-.2 13.4.1 2.2 1.9 3.9 4.1 3.9h17.5c2.2 0 4-1.7 4.1-3.9.5-7.4-.2-13.3-.2-13.4-.3-2.6-.9-5.4-1.9-8.5-.9-2.9-1.4-6.3.1-9 .9-1.8 1.8-4 1.8-6.2.3-9.8-5.8-12.4-8-13.1V8.5h.5c.5 0 1-.4 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2.7-3.7 5.2-.1.5.3 1 .8 1.1h.1c.5 0 .9-.4 1-.8.2-1.7 1.1-3.1 2.5-3.6.5-.2.7-.7.6-1.2-.3-.6-.8-.9-1.3-.7z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(22.000000, 0.000000)\"><\/path><\/g><g><path d=\"M1.2 37.5c0 .2-.6 4.4-.2 10.8.1 1.7 1.6 3.1 3.3 3.1h14c1.7 0 3.2-1.4 3.3-3.1.4-5.9-.2-10.7-.2-10.8-.2-2.1-.7-4.3-1.5-6.8-.8-2.3-1.1-5.1.1-7.2.7-1.4 1.4-3.2 1.5-5 .2-7.8-4.6-10-6.4-10.5V6.6h.4c.4 0 .8-.3.8-.8V2c0-.9-.8-1.7-1.7-1.7H8.2c-.9 0-1.7.8-1.7 1.7v3.8c0 .4.3.8.8.8h.4V8c-1.8.5-6.7 2.7-6.4 10.5 0 1.3.5 3.1 1.5 5 .7 1.3 1.2 3.5.1 7.2-.9 2.4-1.4 4.7-1.7 6.8zm18.9 1.6c.2 2.8.3 5.8 0 9.1-.1.9-.8 1.6-1.7 1.6h-14c-.9 0-1.7-.7-1.7-1.6-.2-3.3-.2-6.3.1-9.1h17.3zM8 2c0-.1.1-.1.1-.1h6.4c.1 0 .1.1.1.1v3H7.9V2H8zm.6 7.3c.4 0 .7-.4.7-.8v-2h4.2v2c0 .4.3.7.7.8.2 0 6 .9 5.8 9H2.8c-.2-8.1 5.5-9 5.8-9zM4.1 22.7c-.8-1.4-1-2.3-1.1-2.9h16.7c-.1.5-.3 1.4-1.1 2.9s-1.5 4.3-.2 8.4c.9 2.7 1.3 4.7 1.4 6.4h-17c.3-2.2.8-4.4 1.5-6.5.9-2.7 1.2-5.8-.2-8.3z\" fill=\"#062059\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(49.000000, 10.000000)\"><\/path><path d=\"M12 23.1c-.3-.5-1-.5-1.3 0-.6.9-3.3 5.6-3.3 7.4 0 2.2 1.8 4 4 4s4-1.8 4-4c-.1-1.8-2.8-6.4-3.4-7.4zM13.7 48.2h2.4c1.3 0 2.3-1 2.3-2.3v-1.3c0-.4-.3-.8-.8-.8-.4 0-.8.3-.8.8v1.3c0 .4-.3.8-.8.8h-2.4c-.4 0-.8.3-.8.8s.5.7.9.7zM8.2 11.6c-1.6.6-2.7 2.2-3 4.1-.1.4.3.8.7.9H6c.4 0 .7-.3.8-.7.2-1.4.9-2.5 2-2.9.4-.2.6-.6.4-1-.1-.4-.6-.6-1-.4z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(49.000000, 10.000000)\"><\/path><\/g><g><path d=\"M1.1 37.5c0 .2-.6 4.4-.2 10.8.1 1.7 1.5 3.1 3.3 3.1h14c1.7 0 3.2-1.4 3.3-3.1.4-5.9-.2-10.7-.2-10.8-.2-2.1-.7-4.3-1.5-6.8-.8-2.3-1.1-5.1.1-7.2.7-1.4 1.4-3.2 1.5-5 .2-7.8-4.6-10-6.4-10.5V6.6h.4c.4 0 .8-.3.8-.8V2c0-.9-.8-1.7-1.7-1.7H8c-.9 0-1.7.8-1.7 1.7v3.8c0 .4.3.8.8.8h.4V8c-1.8.5-6.7 2.7-6.4 10.5 0 1.3.5 3.1 1.5 5 .7 1.3 1.2 3.5.1 7.2-.9 2.4-1.4 4.7-1.6 6.8zm18.8 1.6c.2 2.8.3 5.8 0 9.1-.1.9-.8 1.6-1.7 1.6h-14c-.9 0-1.7-.7-1.7-1.6-.2-3.3-.2-6.3.1-9.1h17.3zM7.8 2c0-.1.1-.1.1-.1h6.4c.1 0 .1.1.1.1v3H7.7V2h.1zm.6 7.3c.4 0 .7-.4.7-.8v-2h4.2v2c0 .4.3.7.7.8.2 0 6 .9 5.8 9H2.6c-.2-8.1 5.5-9 5.8-9zM3.9 22.7c-.8-1.4-1-2.3-1.1-2.9h16.7c-.1.5-.3 1.4-1.1 2.9s-1.5 4.3-.2 8.4c.9 2.7 1.3 4.7 1.4 6.4h-17c.3-2.2.8-4.4 1.5-6.5.9-2.7 1.2-5.8-.2-8.3z\" fill=\"#062059\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(0.000000, 10.000000)\"><\/path><path d=\"M11.8 23.1c-.3-.5-1-.5-1.3 0-.6.9-3.3 5.6-3.3 7.4 0 2.2 1.8 4 4 4s4-1.8 4-4c-.1-1.8-2.8-6.4-3.4-7.4zM13.5 48.2H16c1.3 0 2.3-1 2.3-2.3v-1.3c0-.4-.3-.8-.8-.8-.4 0-.8.3-.8.8v1.3c0 .4-.3.8-.8.8h-2.4c-.4 0-.8.3-.8.8s.4.7.8.7zM8 11.6c-1.6.6-2.7 2.2-3 4.1-.1.4.3.8.7.9h.1c.4 0 .7-.3.8-.7.2-1.4.9-2.5 2-2.9.4-.1.6-.6.4-1-.1-.4-.6-.6-1-.4z\" fill=\"#1F99D5\" transform=\"translate(-75.000000, -188.000000) translate(75.000000, 188.000000) translate(9.000000, 12.000000) translate(0.000000, 10.000000)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tUn diagn\u00f3stico y una intervenci\u00f3n tempranos son clave para atenuar el da\u00f1o<sup>2\u20136<\/sup>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8c6d55 elementor-widget elementor-widget-text-editor\" data-id=\"d8c6d55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLos enfoques de manejo pueden disminuir el da\u00f1o al reducir la formaci\u00f3n de c\u00e1lculos y la deposici\u00f3n renal de cristales de oxalato c\u00e1lcico; lo cual destaca la importancia de un diagn\u00f3stico y una intervenci\u00f3n tempranos.<sup>3,7,8<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-834924a e-flex e-con-boxed e-con e-parent\" data-id=\"834924a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d45841f elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d45841f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/conocer-los-signos\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conocer los signos<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-81dc0fb elementor-widget elementor-widget-heading\" data-id=\"81dc0fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LA HP1 ES PROGRESIVA Y SIST\u00c9MICA<sup>2,9<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb170e3 elementor-widget elementor-widget-heading\" data-id=\"fb170e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">C\u00f3mo la HP1 puede ser potencialmente mortal<sup>2<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d8ed625 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"d8ed625\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/PH1-ESP-00110-AnimatedPH1_MechanismofDisease_video-part2_Spanish.jpg&quot;,&quot;id&quot;:5110,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Miniatura de v\\u00eddeo Mecanismo de la HP1&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1043694105?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1&amp;h=1c31f6ba5e#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ESP-00110-AnimatedPH1_MechanismofDisease_video-part2_Spanish.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Miniatura de v\u00eddeo Mecanismo de la HP1\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93c3cee elementor-widget elementor-widget-text-editor\" data-id=\"93c3cee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La HP1 da lugar a un deterioro progresivo de la funci\u00f3n renal.<sup>2<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-18b58b1 e-flex e-con-boxed e-con e-parent\" data-id=\"18b58b1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-490699c elementor-widget elementor-widget-heading\" data-id=\"490699c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">EL EXCESO DE OXALATO PUEDE DA\u00d1AR LOS RI\u00d1ONES<sup>9<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9e086d elementor-widget elementor-widget-text-editor\" data-id=\"e9e086d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La hiperproducci\u00f3n de oxalato en el h\u00edgado puede dar lugar a inflamaci\u00f3n y deterioro progresivo de la funci\u00f3n renal tras la formaci\u00f3n de cristales de oxalato c\u00e1lcico.<sup>8,9<\/sup> La hiperproducci\u00f3n continua de oxalato puede dar lugar a un da\u00f1o irreversible en los ri\u00f1ones y otros \u00f3rganos.<sup>8,9<\/sup><\/p>\n<p>La HP1 avanza a velocidades variables y progresa a ERT.<sup>2<\/sup> Cuando los ri\u00f1ones no son capaces de excretar el oxalato de forma eficaz debido a la toxicidad del dep\u00f3sito de cristales de oxalato c\u00e1lcico, se puede producir oxalosis sist\u00e9mica, es decir, una deposici\u00f3n tisular extendida de oxalato c\u00e1lcico.<sup>9<\/sup> Las complicaciones de la oxalosis sist\u00e9mica pueden ser mortales.<sup>2<\/sup><\/p>\n<p>En algunos casos, la funci\u00f3n renal puede deteriorarse tras un \u00fanico episodio de deshidrataci\u00f3n debido a una enfermedad aguda o por una actividad f\u00edsica intensa.<sup>10\u201313<\/sup> Esto puede suceder incluso en pacientes con enfermedad previamente estable.<sup>9,11<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6c8909 e-flex e-con-boxed e-con e-parent\" data-id=\"c6c8909\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-03585b9 e-flex e-con-boxed e-con e-child\" data-id=\"03585b9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b15ab3d elementor-widget elementor-widget-heading\" data-id=\"b15ab3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u00bfQU\u00c9 CAUSA LA HIPERPRODUCCI\u00d3N DE OXALATO EN LA HP1?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1da21d elementor-widget elementor-widget-heading\" data-id=\"c1da21d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Incapacidad de la AGT de procesar el glioxilato producido por la GO<sup>2<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ba4b4cd e-grid e-con-boxed e-con e-child\" data-id=\"ba4b4cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef80976 elementor-widget elementor-widget-text-editor\" data-id=\"ef80976\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La HP1 es una enfermedad gen\u00e9tica causada por mutaciones en el gen <em>AGXT<\/em> que hace disfuncional a la enzima hep\u00e1tica AGT.<sup class=\"sup\">3<\/sup><\/p><p class=\"mb-70 mob-mb-40\">Normalmente, la AGT procesa el glioxilato, que es generado por otra enzima hep\u00e1tica, la GO.<sup class=\"sup\">2,3<\/sup> En la HP1, un defecto en la AGT hace que el glioxilato se convierta, al final, en oxalato.<sup class=\"sup\">2<\/sup> El oxalato no se puede metabolizar y suele ser excretado por los ri\u00f1ones a niveles normales.<sup class=\"sup\">3<\/sup> Cuando hay hiperproducci\u00f3n, como ocurre en la HP1, el oxalato puede causar un da\u00f1o irreversible progresivo.<sup class=\"sup\">2<\/sup> El oxalato se combina con el calcio y crea cristales de oxalato c\u00e1lcico.<sup class=\"sup\">2<\/sup> Estos cristales se adhieren a los tejidos renales, donde pueden agregarse para formar c\u00e1lculos renales o causar nefrocalcinosis.<sup class=\"sup\">2,9<\/sup> A medida que el oxalato c\u00e1lcico se acumula, la excreci\u00f3n de los ri\u00f1ones se altera y los cristales se depositan por todo el cuerpo.<sup>9<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-545ff66 e-flex e-con-boxed e-con e-child\" data-id=\"545ff66\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-579544e elementor-widget elementor-widget-heading\" data-id=\"579544e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Descargar un resumen de la HP1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f62fbc elementor-widget elementor-widget-image\" data-id=\"4f62fbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"849\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/SpanishPH1DSABrochureCEMEAupdated_old-logo-2.jpg\" class=\"attachment-full size-full wp-image-5121\" alt=\"HP1 - Informaci\u00f3n general - Miniatura de folleto\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/SpanishPH1DSABrochureCEMEAupdated_old-logo-2.jpg 600w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/SpanishPH1DSABrochureCEMEAupdated_old-logo-2-212x300.jpg 212w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1af67c3 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"1af67c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/downloads\/es\/PH1-ESP-00127-PH1-DSA-Brochure-Spain-2024.pdf\" target=\"_blank\" download=\"Folleto de la HP1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"15\" viewBox=\"0 0 16 15\"><path fill=\"#D0191F\" fill-rule=\"evenodd\" d=\"M14.28 7.58a.5.5 0 0 1 1 0v4.825c0 .643-.263 1.227-.685 1.65a2.332 2.332 0 0 1-1.65.685H2.335a2.328 2.328 0 0 1-1.65-.685A2.324 2.324 0 0 1 0 12.405V7.58a.5.5 0 0 1 1 0v4.825a1.335 1.335 0 0 0 1.334 1.334h10.611a1.338 1.338 0 0 0 1.334-1.334V7.58zm-9.958-.854a.5.5 0 0 1 .707-.707l2.111 2.11V.5a.5.5 0 0 1 1 0v7.63l2.11-2.11a.5.5 0 0 1 .707.707l-2.96 2.96a.453.453 0 0 1-.032.03l-.018.015-.004.003-.008.006-.008.006-.005.004-.004.002-.006.005-.004.003-.006.003-.008.005a.508.508 0 0 1-.508 0l-.009-.005-.004-.003-.004-.003-.008-.005-.002-.002-.006-.004-.008-.006h-.002l-.005-.006-.004-.003a.173.173 0 0 1-.02-.014c-.012-.01-.02-.02-.03-.031l-2.962-2.96z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Descargar<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-06906e6 e-flex e-con-boxed e-con e-parent\" data-id=\"06906e6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-88643fd e-con-full e-flex e-con e-child\" data-id=\"88643fd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5196e77 elementor-widget elementor-widget-image\" data-id=\"5196e77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"247\" height=\"249\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle.png\" class=\"attachment-large size-large wp-image-5166\" alt=\"Kim Hollander - Directora ejecutiva - Oxalosis and Hyperoxaluria Foundation\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle.png 247w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/oxalosis-and-hyperoxaluria-foundation-executive-director-kim-hollander-headshot-circle-150x150.png 150w\" sizes=\"(max-width: 247px) 100vw, 247px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-11e20b3 e-con-full e-flex e-con e-child\" data-id=\"11e20b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22d351c elementor-widget elementor-widget-text-editor\" data-id=\"22d351c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00abDada la naturaleza de esta enfermedad, la HP1 puede permanecer sin diagnosticarse durante muchos a\u00f1os. Los s\u00edntomas tempranos en adultos, como los c\u00e1lculos renales, se suelen atribuir a otras afecciones mucho m\u00e1s comunes. Tenemos que ayudar a los m\u00e9dicos a reconocer los s\u00edntomas m\u00e1s r\u00e1pidamente, para detener la progresi\u00f3n antes de que el paciente llegue a la enfermedad renal terminal\u00bb.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c2cfe8 elementor-widget elementor-widget-text-editor\" data-id=\"6c2cfe8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Kim Hollander<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a69df67 person-role elementor-widget elementor-widget-text-editor\" data-id=\"a69df67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDirectora ejecutiva de <a style=\"color: #1f99d5;\" href=\"https:\/\/ohf.org\/\" rel=\"nofollow\" class=\"external\">Oxalosis and Hyperoxaluria Foundation<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe7e8fc e-flex e-con-boxed e-con e-parent\" data-id=\"fe7e8fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-094ad73 elementor-hidden-tablet elementor-hidden-mobile elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"094ad73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc862c8 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"dc862c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/conocer-los-signos\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">IR A <span>CONOCER LOS SIGNOS<span style=\"background-color: var( --e-global-color-5a8cfc1 );color: var( --e-global-color-accent );font-size: 32px\"><\/span><\/span><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e996090 e-flex e-con-boxed e-con e-parent\" data-id=\"e996090\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4dda9423 e-con-full e-flex e-con e-child\" data-id=\"4dda9423\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27f870e6 elementor-widget elementor-widget-heading\" data-id=\"27f870e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pruebas a pacientes para detectar la HP1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33003895 elementor-widget elementor-widget-text-editor\" data-id=\"33003895\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Vea c\u00f3mo las pruebas gen\u00e9ticas desempe\u00f1an un papel importante en el diagn\u00f3stico de la HP1.<sup>2,4<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61982d65 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"61982d65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/pruebas-de-hp1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Opciones de pruebas<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2525b1e4 e-con-full e-flex e-con e-child\" data-id=\"2525b1e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b4575f8 elementor-widget elementor-widget-heading\" data-id=\"5b4575f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Obtener informaci\u00f3n actualizada<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37f042f4 elementor-widget elementor-widget-text-editor\" data-id=\"37f042f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Registrarse para recibir informaci\u00f3n de Alnylam sobre la HP1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6c5f16 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c6c5f16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Registrarse<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ae63e4 e-flex e-con-boxed e-con e-parent\" data-id=\"1ae63e4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-478a2d1 elementor-widget elementor-widget-text-editor\" data-id=\"478a2d1\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"footer-refs\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Referencias: 1.<\/strong> Hoppe B. <em>Nat Rev Nephrol<\/em>. 2012;8(8):467\u2013475. <strong>2.<\/strong> Milliner DS, Harris PC, Sas DJ, <em>et al.<\/em> Primary hyperoxaluria type 1. GeneReviews<sup>\u00ae<\/sup> [<em>Internet<\/em>]. Actualizado el 15 de agosto de 2024. Consultado en enero de 2026.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/<\/a>\u00a0<strong>3.<\/strong> Cochat P, Rumsby G. <em>N Engl J Med<\/em>. 2013;369(7):649\u2013658. <strong>4.<\/strong> Cochat P, Hulton SA, Acquaviva C, <em>et al. Nephrol Dial Transplant.<\/em> 2012;27(5):1729\u20131736. <strong>5.<\/strong> Ben-Shalom E, Frishberg Y. <em>Pediatr Nephrol<\/em>. 2015;30(10):1781\u20131791. <strong>6.<\/strong> Raju DL, Cantarovich M, Brisson ML, <em>et al. Am J Kidney Dis.<\/em> 2008;51(1):e1\u2013e5. <strong>7.<\/strong> Bhasin B, \u00dcrekli HM, Atta MG. <em>World J Nephrol<\/em>. 2015;4(2):235\u2013244. <strong>8.<\/strong> Hoppe B, Beck BB, Milliner DS. <em>Kidney Int<\/em>. 2009;75(12):1264\u20131271. <strong>9.<\/strong> Leumann E, Hoppe B. <em>J Am Soc Nephrol<\/em>. 2001;12(9):1986\u20131993. <strong>10.<\/strong> El-Reshaid K, Al-Bader D, Madda JP. <em>Saudi J Kidney Dis Transpl<\/em>. 2016;27(3):606\u2013609. <strong>11.<\/strong> Cochat P. <em>Kidney Int<\/em>. 1999;55(6):2533\u20132547. <strong>12.<\/strong> Harambat J, Fargue S, Bacchetta J, <em>et al. Int J Nephrol.<\/em> 2011;2011:864580. <strong>13.<\/strong> Tintillier M, Pochet JM, Cosyns JP, <em>et al. Clin Nephrol.<\/em> 2004;62(2):155\u2013157.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60902a3 elementor-widget elementor-widget-text-editor\" data-id=\"60902a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>PH1-ESP-00173 | Enero de 2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Obtenga informaci\u00f3n sobre la hiperoxaluria primaria de tipo 1 (HP1), una enfermedad gen\u00e9tica progresiva rara que a menudo se presenta con c\u00e1lculos renales y puede causar un da\u00f1o renal irreversible.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-4521","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages\/4521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/comments?post=4521"}],"version-history":[{"count":122,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages\/4521\/revisions"}],"predecessor-version":[{"id":8837,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages\/4521\/revisions\/8837"}],"wp:attachment":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/media?parent=4521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}