{"id":4496,"date":"2024-06-03T13:54:12","date_gmt":"2024-06-03T13:54:12","guid":{"rendered":"https:\/\/www.thinkph1.eu\/?page_id=4496"},"modified":"2026-01-15T15:51:25","modified_gmt":"2026-01-15T15:51:25","slug":"hp1-litiasis-renal-metabolica","status":"publish","type":"page","link":"https:\/\/www.thinkph1.eu\/es\/","title":{"rendered":"HP1: Litiasis renal metab\u00f3lica | Think PH1\u2122"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4496\" class=\"elementor elementor-4496 elementor-22\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-094e2f1 randomBGImage e-con-full e-flex e-con e-parent\" data-id=\"094e2f1\" data-element_type=\"container\" data-e-type=\"container\" id=\"bgID\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\" data-images=\"\/wp-content\/uploads\/2024\/06\/behind-the-stone-ph1-adolescent-on-dialysis-banner-large.jpg,\/wp-content\/uploads\/2024\/06\/behind-the-stone-ph1-adult-on-dialysis-banner-large.jpg,\/wp-content\/uploads\/2024\/06\/behind-the-stone-ph1-child-on-dialysis-banner-large.jpg\">\n\t\t<div class=\"elementor-element elementor-element-c6ce04c e-flex e-con-boxed e-con e-child\" data-id=\"c6ce04c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0caa92a e-flex e-con-boxed e-con e-child\" data-id=\"0caa92a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c9ada73 eael-dual-header-content-align-left elementor-widget elementor-widget-eael-dual-color-header\" data-id=\"c9ada73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-dual-color-header.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"eael-dual-header\">\n\t\t\t\t<span class=\"subtext\"><p>\u00bfQU\u00c9 M\u00c1S PUEDE HABER<\/p><\/span>\n\t\t\t\t<h2 class=\"title eael-dch-title\"><span class=\"eael-dch-title-text eael-dch-title-lead lead solid-color\">DETR\u00c1S<\/span> <span class=\"eael-dch-title-text\">DEL C\u00c1LCULO? <\/span><\/h2>\t\t\t\t\t\t\t\t\t<span class=\"eael-dch-svg-icon\"><\/span>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4d28e4 elementor-widget elementor-widget-text-editor\" data-id=\"c4d28e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La recurrencia de c\u00e1lculos renales en un adulto o cualquier c\u00e1lculo renal en un ni\u00f1o pueden ser signos tempranos de una enfermedad metab\u00f3lica asociada a la litiasis con consecuencias potencialmente devastadoras, como la hiperoxaluria primaria de tipo 1 (HP1).<sup>1\u20134&nbsp;<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-caffbea elementor-align-left elementor-widget elementor-widget-button\" data-id=\"caffbea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/descubrir-la-hp1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">M\u00e1s sobre la HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7e2ee69 e-flex e-con-boxed e-con e-child\" data-id=\"7e2ee69\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f2a73f elementor-absolute e-transform elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"2f2a73f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;none&quot;,&quot;_transform_translateX_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:-24,&quot;sizes&quot;:[]},&quot;motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;motion_fx_translateX_effect&quot;:&quot;yes&quot;,&quot;motion_fx_translateX_direction&quot;:&quot;negative&quot;,&quot;motion_fx_translateX_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:5,&quot;sizes&quot;:[]},&quot;motion_fx_translateX_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;_transform_translateX_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateX_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_translateY_effect_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1100\" height=\"474\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone.png\" class=\"attachment-full size-full wp-image-3974\" alt=\"C\u00e1lculo de oxalato c\u00e1lcico - C\u00e1lculo renal\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone.png 1100w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone-300x129.png 300w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone-1024x441.png 1024w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/calcium-oxalate-kidney-stone-768x331.png 768w\" sizes=\"(max-width: 1100px) 100vw, 1100px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0e5a07a e-flex e-con-boxed e-con e-parent\" data-id=\"0e5a07a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-be23a4b elementor-widget elementor-widget-heading\" data-id=\"be23a4b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">No pasar por alto ning\u00fan c\u00e1lculo renal<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e959b14 elementor-widget elementor-widget-heading\" data-id=\"e959b14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Cualquier c\u00e1lculo inusual puede ser un signo de una enfermedad metab\u00f3lica asociada a la litiasis, <br>como la hiperoxaluria de tipo 1, y merece una investigaci\u00f3n adicional<sup>1,2<\/sup><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-506f531 e-flex e-con-boxed e-con e-parent\" data-id=\"506f531\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cc978a2 e-con-full e-flex e-con e-child\" data-id=\"cc978a2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element 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1.774-2.653z\" transform=\"translate(-363 -1056) translate(215 872) translate(0 184) translate(149)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tNi\u00f1os o adolescentes\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tCualquier c\u00e1lculo o antecedentes familiares de c\u00e1lculos renales pueden ser se\u00f1ales de alarma.<sup>1,3\u20135<\/sup>\n\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad70bc6 e-con-full e-flex e-con e-child\" data-id=\"ad70bc6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31a330f 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3.275-9.555c.174-1.182.273-2.375.36-3.514l.131-1.53v-.205c-.12-3.45-.426-7.451-2.587-11.139-3.701-6.312-9.27-9.349-16.573-9.056a14.076 14.076 0 0 0-7.206 2.028c-3.646 2.343-5.546 5.922-5.633 10.64a10.15 10.15 0 0 0 1.004 4.544 1.68 1.68 0 0 0 2.222.819 1.66 1.66 0 0 0 .824-2.207 6.815 6.815 0 0 1-.611-3.091c.076-3.59 1.42-6.182 4.116-7.906a10.643 10.643 0 0 1 5.459-1.508c5.609-.482 10.957 2.442 13.548 7.408 1.583 2.7 1.998 5.737 2.184 9.478 0 .489-.088.977-.12 1.454-.099 1.15-.186 2.234-.339 3.308a19.932 19.932 0 0 1-2.806 8.22c-2.85 4.339-6.375 6.508-10.764 6.508h-.874a7.848 7.848 0 0 1-5.83-2.755c-1.746-2.071-2.587-5.238.284-7.906a1.662 1.662 0 0 0-.016-2.267 1.69 1.69 0 0 0-2.276-.163A8.652 8.652 0 0 0 53.08 44a9.562 9.562 0 0 0 2.292 6.02 11.142 11.142 0 0 0 8.2 3.947l1.102.033z\"><\/path><path fill=\"#2098D5\" d=\"M50.532 35.62c2.727-3.29 6.761-5.023 10.006-6.153.38-.85.856-1.656 1.42-2.403a6.616 6.616 0 0 1-1.532-1.865l-1.465-2.5a1.072 1.072 0 0 1-.135-.853c.077-.29.272-.537.54-.683.263-.158.58-.203.879-.127.298.077.55.27.699.532l1.499 2.49c.222.437.503.842.834 1.207a6.504 6.504 0 0 0 1.126-2.358c.128-.606.736-.997 1.358-.872a1.12 1.12 0 0 1 .896 1.321 11.553 11.553 0 0 1-2.321 4.388 13.221 13.221 0 0 0-1.657 2.534 4.41 4.41 0 0 0-.202.538 4.024 4.024 0 0 0-.203 1.338c.023.743.24 1.468.63 2.106a8.883 8.883 0 0 0 2.683 2.732l4.417-1.997 1.51-.416c.622-.17 1.268.184 1.442.79a1.136 1.136 0 0 1-.811 1.404l-1.34.373-2.784 1.25c.906.427 1.853.765 2.828 1.01.294.064.549.242.708.491.159.25.208.55.137.836a1.122 1.122 0 0 1-1.127.844c-.093.011-.188.011-.281 0a19.036 19.036 0 0 1-5.128-2.194 1.13 1.13 0 0 1-.664-.416 11.331 11.331 0 0 1-3.573-3.599 6.47 6.47 0 0 1-.845-2.281 16.935 16.935 0 0 0-6.952 4.552c-3.313 3.993-3.088 9.763-2.322 13.899.372 1.996.913 4.015 1.431 5.978a54.344 54.344 0 0 1 1.95 9.742 27.936 27.936 0 0 1-.642 8.468c-.165.738-.836 1.264-1.612 1.262a1.435 1.435 0 0 1-.372 0 1.646 1.646 0 0 1-1.06-.708 1.566 1.566 0 0 1-.213-1.234c.575-2.474.765-5.018.563-7.547a51.605 51.605 0 0 0-1.859-9.182c-.53-2.018-1.127-4.091-1.476-6.198-.868-4.804-1.07-11.562 3.02-16.498z\"><\/path><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tAdultos\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tLos c\u00e1lculos renales recurrentes y\/o inusuales* pueden ser se\u00f1ales de alarma.<sup>1,6\u20139<\/sup><br><br>\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0d49b23 e-con-full e-flex e-con e-child\" data-id=\"0d49b23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d9703b3 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"d9703b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"align-center\" width=\"60\" height=\"62\" viewBox=\"0 0 60 62\"><g fill=\"none\" fill-rule=\"evenodd\"><g fill-rule=\"nonzero\"><g><g><g><path fill=\"#1E2656\" d=\"M33.13 34.296c.27-.123.562-.222.87-.296H10v1h21.595c.487-.258 1-.493 1.536-.704zM39.598 26.516c.137-.183.275-.334.402-.516H9v1h30.255c.155-.148.27-.312.343-.484z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><path fill=\"#1E2656\" d=\"M49.808 39.418V56.46c0 .742-.711 2.166-1.874 2.146H5.364c-.567.006-1.113-.22-1.514-.628-.402-.407-.625-.961-.62-1.537l-.058-38.072h16.68V3.385l26.62.097c2.442-.117 3.26.615 3.317 2.624v9.52c1.327-.809 2.278-.555 3.211-.975V4.897C52.394 2.595 51.385.02 46.01.166L19.286 0H16.92L0 15.441v40.97C0 59.035 2.403 62 5 62l42.645-.176c1.42.01 2.785-.556 3.791-1.573 1.006-1.017 1.57-2.4 1.564-3.84V38.579c-.308.137-2.346.634-3.192.84zM16.92 4.068V15.44H3.932L16.92 4.068z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><path fill=\"#1E2656\" d=\"M27 43H10v1h16.272c.22-.342.463-.676.728-1z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><path fill=\"#2098D5\" d=\"M58.628 21.564l-.667-.069-.067.674c-.136 1.211-.382 2.408-.735 3.574L52.135 21.7c1.036-.593 2.122-1.09 3.247-1.484l.599-.205-.6-2.011-.608.195c-2.594.956-5.011 2.346-7.15 4.11-.846.718-1.631 1.505-2.348 2.354-.84 1.008-1.514 2.145-2 3.368-1 2.499-1.236 5.244-.676 7.88-2.677.019-5.29.837-7.507 2.353-1.065.752-2.012 1.66-2.812 2.694-.691.855-1.296 1.777-1.807 2.754-1.249 2.465-2.063 5.131-2.405 7.879L28 52.26l1.41.136.667.069.068-.674c.14-1.188.386-2.362.734-3.505l4.937 4.013c-1.027.58-2.1 1.073-3.207 1.474l-.6.205.667 2.021.6-.205c2.595-.954 5.015-2.34 7.159-4.1.86-.704 1.659-1.481 2.386-2.324.815-1.014 1.467-2.151 1.933-3.369.997-2.5 1.23-5.245.666-7.88 2.67-.028 5.273-.846 7.488-2.352 1.062-.755 2.01-1.663 2.812-2.695.694-.856 1.3-1.782 1.807-2.763 1.252-2.46 2.066-5.124 2.405-7.87L60 21.77l-1.372-.205zm-19.469 28.47c-.463.41-.966.742-1.4 1.084l-6.088-4.882c.203-.537.474-1.074.735-1.679.203-.332.338-.674.54-.976l6.977 5.584c-.217.322-.474.614-.764.87zm2.145-2.216l-7.178-5.79c.612-.777 1.335-1.458 2.145-2.02l6.55 5.32c-.406.888-.916 1.724-1.517 2.49zm2.136-4.579l-5.45-4.374c1.659-.75 3.472-1.085 5.285-.977.482 1.744.539 3.58.165 5.351zm1.41-7.274c-.434-1.74-.467-3.557-.096-5.311l5.352 4.305c-1.644.766-3.449 1.112-5.256 1.006zm7.024-2.08l-6.56-5.32c.402-.882.897-1.717 1.478-2.49l7.15 5.79c-.567.79-1.267 1.474-2.068 2.02zm3.865-4.647l-.599.976-7.024-5.653c.274-.284.565-.55.87-.8.463-.41.966-.743 1.4-1.084l6.087 4.882c-.207.574-.449 1.135-.724 1.679h-.01z\" transform=\"translate(-1170 -1056) translate(215 872) translate(800 184) translate(155)\"><\/path><\/g><\/g><\/g><\/g><\/g><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tPruebas\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tSe puede realizar un estudio de orina de 24 horas para ayudar a detectar la enfermedad metab\u00f3lica asociada a litiasis.<sup>10\u201312<\/sup>\n\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d1dcbef e-flex e-con-boxed e-con e-parent\" data-id=\"d1dcbef\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-89ef038 elementor-widget elementor-widget-text-editor\" data-id=\"89ef038\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size:16px;\">*Incluidos los c\u00e1lculos m\u00faltiples, bilaterales y\/o grandes.<\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17fa546 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"17fa546\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/pruebas-de-hp1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Ir a las pruebas de HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1db4af6 e-flex e-con-boxed e-con e-parent\" data-id=\"1db4af6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2e7b831 e-con-full e-flex e-con e-child\" data-id=\"2e7b831\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0342f95 elementor-widget elementor-widget-heading\" data-id=\"0342f95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">LA HP1 ES UNA ENFERMEDAD HEREDITARIA RARA, PROGRESIVA Y POTENCIALMENTE MORTAL.<sup>3,4<\/sup><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-53d81f0 e-con-full e-flex e-con e-child\" data-id=\"53d81f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fbc7d69 elementor-widget elementor-widget-image\" data-id=\"fbc7d69\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"492\" height=\"264\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/primary-hyperoxaluria-type-1-mechanism-of-disease.png\" class=\"attachment-large size-large wp-image-3962\" alt=\"Mecanismo de la enfermedad hiperoxaluria primaria de tipo 1 (HP1) - Interacci\u00f3n de h\u00edgado y ri\u00f1\u00f3n\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/primary-hyperoxaluria-type-1-mechanism-of-disease.png 492w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/primary-hyperoxaluria-type-1-mechanism-of-disease-300x161.png 300w\" sizes=\"(max-width: 492px) 100vw, 492px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f496017 e-con-full e-flex e-con e-child\" data-id=\"f496017\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-79642b8 elementor-widget elementor-widget-text-editor\" data-id=\"79642b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La HP1 est\u00e1 causada por mutaciones autos\u00f3micas recesivas en el gen <em>AGXT<\/em>, que dan lugar a una hiperproducci\u00f3n de oxalato en el h\u00edgado.<sup>3,4<\/sup> Con el paso del tiempo, la hiperproducci\u00f3n de oxalato puede causar un deterioro progresivo de la funci\u00f3n renal.<sup>2,4<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-070b5b0 elementor-align-left elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"070b5b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/descubrir-la-hp1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Descubrir la HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dcc5ba1 e-flex e-con-boxed e-con e-parent\" data-id=\"dcc5ba1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-11679f0 e-con-full e-flex e-con e-child\" data-id=\"11679f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8081c64 elementor-widget elementor-widget-heading\" data-id=\"8081c64\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">LA SOSPECHA DE HP1 DEBER\u00cdA SER ALTA EN PACIENTES NO DIAGNOSTICADOS CON S\u00cdNTOMAS DE ALERTA PROCEDENTES DE ZONAS CON TASAS ELEVADAS DE HP1<sup>13<\/sup><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1bd0945 e-con-full e-flex e-con e-child\" data-id=\"1bd0945\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-17bb91a elementor-widget elementor-widget-text-editor\" data-id=\"17bb91a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Los informes publicados indican una prevalencia de HP1 superior a la media en las siguientes poblaciones:<sup>13<\/sup><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0141101 elementor-widget elementor-widget-image\" data-id=\"0141101\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"453\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-es-1-1024x580.jpg\" class=\"attachment-large size-large wp-image-8313\" alt=\"PH1 Prevalence map\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-es-1-1024x580.jpg 1024w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-es-1-300x170.jpg 300w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-es-1-768x435.jpg 768w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/population-map-1-es-1.jpg 1140w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-116bd2d e-con-full e-flex e-con e-child\" data-id=\"116bd2d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-063584d elementor-widget elementor-widget-text-editor\" data-id=\"063584d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Vea al Dr. Moochhala explicar c\u00f3mo la consanguinidad puede elevar el riesgo de HP1 y por qu\u00e9 resulta fundamental tenerla en cuenta al evaluar a pacientes con c\u00e1lculos renales de causa desconocida.<\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e59619e animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"e59619e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/dr-shabbir-moochhala-es.jpg&quot;,&quot;id&quot;:8753,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Dr. Moochhala KOL video&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1143804572?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2026\/01\/dr-shabbir-moochhala-es.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Dr. Moochhala KOL video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34fd73f e-flex e-con-boxed e-con e-parent\" data-id=\"34fd73f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5dc388a e-con-full e-flex e-con e-child\" data-id=\"5dc388a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-23f1689 elementor-widget elementor-widget-heading\" data-id=\"23f1689\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">HP1: INFRADIAGNOSTICADA Y RETRASO EN EL DIAGN\u00d3STICO<sup>8,14\u201317<\/sup><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e68bdb3 elementor-widget elementor-widget-heading\" data-id=\"e68bdb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">El diagn\u00f3stico se suele retrasar cuando se pasa por alto la HP1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4dfe011 e-con-full e-flex e-con e-child\" data-id=\"4dfe011\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53b6f9f elementor-widget elementor-widget-eael-progress-bar\" data-id=\"53b6f9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-progress-bar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-progressbar-circle-container center\">\n                \n            \n                <div class=\"eael-progressbar eael-progressbar-circle\" data-layout=\"circle\" data-count=\"50\" data-duration=\"1500\">\n                    <div class=\"eael-progressbar-circle-pie\">\n                        <div class=\"eael-progressbar-circle-half-left eael-progressbar-circle-half\"><\/div>\n                        <div class=\"eael-progressbar-circle-half-right eael-progressbar-circle-half\"><\/div>\n                    <\/div>\n                    <div class=\"eael-progressbar-circle-inner\"><\/div>\n                    <div class=\"eael-progressbar-circle-inner-content\">\n                        <div class=\"eael-progressbar-title\">EL<br><span>~<\/span><\/div>\n                        <span class=\"eael-progressbar-count-wrap\"><span class=\"eael-progressbar-count\">0<\/span><span class=\"postfix\">%<\/span><\/span>\n                    <\/div>\n                <\/div>\n\n                \n            <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ecabaa elementor-widget elementor-widget-text-editor\" data-id=\"4ecabaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>de los pacientes con HP1 pueden estar infradiagnosticados, aunque los datos de prevalencia son limitados.<sup>17<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6f8f9ee e-con-full e-flex e-con e-child\" data-id=\"6f8f9ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3674a62 elementor-widget elementor-widget-eael-progress-bar\" data-id=\"3674a62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-progress-bar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-progressbar-circle-container center\">\n                \n            \n                <div class=\"eael-progressbar eael-progressbar-circle\" data-layout=\"circle\" data-count=\"55\" data-duration=\"1500\">\n                    <div class=\"eael-progressbar-circle-pie\">\n                        <div class=\"eael-progressbar-circle-half-left eael-progressbar-circle-half\"><\/div>\n                        <div class=\"eael-progressbar-circle-half-right eael-progressbar-circle-half\"><\/div>\n                    <\/div>\n                    <div class=\"eael-progressbar-circle-inner\"><\/div>\n                    <div class=\"eael-progressbar-circle-inner-content\">\n                        <span class=\"eael-progressbar-title\">5,5 <br><span>A\u00d1OS<\/span><\/span>\n                        <span class=\"eael-progressbar-count-wrap\" style=\"display: none;\"><span class=\"eael-progressbar-count\">0<\/span><span class=\"postfix\">%<\/span><\/span>\n                    <\/div>\n                <\/div>\n\n                \n            <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1260fd elementor-widget elementor-widget-text-editor\" data-id=\"b1260fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>es la mediana del retraso del diagn\u00f3stico en adultos desde el inicio de las manifestaciones cl\u00ednicas.<sup>15<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-87663c0 e-con-full e-flex e-con e-child\" data-id=\"87663c0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-55d4d6c elementor-widget elementor-widget-eael-progress-bar\" data-id=\"55d4d6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-progress-bar.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-progressbar-circle-container center\">\n                \n            \n                <div class=\"eael-progressbar eael-progressbar-circle\" data-layout=\"circle\" data-count=\"70\" data-duration=\"1500\">\n                    <div class=\"eael-progressbar-circle-pie\">\n                        <div class=\"eael-progressbar-circle-half-left eael-progressbar-circle-half\"><\/div>\n                        <div class=\"eael-progressbar-circle-half-right eael-progressbar-circle-half\"><\/div>\n                    <\/div>\n                    <div class=\"eael-progressbar-circle-inner\"><\/div>\n                    <div class=\"eael-progressbar-circle-inner-content\">\n                        <div class=\"eael-progressbar-title\">HASTA<br>UN<\/div>\n                        <span class=\"eael-progressbar-count-wrap\"><span class=\"eael-progressbar-count\">0<\/span><span class=\"postfix\">%<\/span><\/span>\n                    <\/div>\n                <\/div>\n\n                \n            <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-233393e elementor-widget elementor-widget-text-editor\" data-id=\"233393e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>de los diagn\u00f3sticos en adultos se realizan despu\u00e9s de progresar a la enfermedad renal terminal (ERT).<sup>14,18\u201321<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e8f799e e-flex e-con-boxed e-con e-parent\" data-id=\"e8f799e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ed6d46b e-con-full e-flex e-con e-child\" data-id=\"ed6d46b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5edec30 elementor-align-right elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"5edec30\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/conocer-los-signos\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conocer los signos<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-60b866c e-con-full e-flex e-con e-child\" data-id=\"60b866c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8490d00 elementor-align-left elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"8490d00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/downloads\/es\/PH1-ESP-00127-PH1-DSA-Brochure-Spain-2024.pdf\" target=\"_blank\" download=\"Folleto de la HP1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"15\" viewBox=\"0 0 16 15\"><path fill=\"#D0191F\" fill-rule=\"evenodd\" d=\"M14.28 7.58a.5.5 0 0 1 1 0v4.825c0 .643-.263 1.227-.685 1.65a2.332 2.332 0 0 1-1.65.685H2.335a2.328 2.328 0 0 1-1.65-.685A2.324 2.324 0 0 1 0 12.405V7.58a.5.5 0 0 1 1 0v4.825a1.335 1.335 0 0 0 1.334 1.334h10.611a1.338 1.338 0 0 0 1.334-1.334V7.58zm-9.958-.854a.5.5 0 0 1 .707-.707l2.111 2.11V.5a.5.5 0 0 1 1 0v7.63l2.11-2.11a.5.5 0 0 1 .707.707l-2.96 2.96a.453.453 0 0 1-.032.03l-.018.015-.004.003-.008.006-.008.006-.005.004-.004.002-.006.005-.004.003-.006.003-.008.005a.508.508 0 0 1-.508 0l-.009-.005-.004-.003-.004-.003-.008-.005-.002-.002-.006-.004-.008-.006h-.002l-.005-.006-.004-.003a.173.173 0 0 1-.02-.014c-.012-.01-.02-.02-.03-.031l-2.962-2.96z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Descargar el folleto de la HP1<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc5b474 e-flex e-con-boxed e-con e-parent\" data-id=\"cc5b474\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2bce96d e-con-full e-flex e-con e-child\" data-id=\"2bce96d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59e05f1 elementor-widget elementor-widget-heading\" data-id=\"59e05f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Registrarse para recibir m\u00e1s informaci\u00f3n sobre la HP1<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-48656ef elementor-mobile-align-center elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"48656ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conect\u00e9monos<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1f2359f e-con-full e-flex e-con e-child\" data-id=\"1f2359f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8a20469 elementor-widget elementor-widget-image\" data-id=\"8a20469\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/laptop-icon.png\" class=\"attachment-large size-large wp-image-3965\" alt=\"Icono de port\u00e1til\" srcset=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/laptop-icon.png 300w, https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/laptop-icon-150x150.png 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-44b788d e-flex e-con-boxed e-con e-parent\" data-id=\"44b788d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dfd856 elementor-widget elementor-widget-heading\" data-id=\"5dfd856\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">ENFOQUES DE MANEJO DE LA HP1<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbbd4a9 elementor-widget elementor-widget-text-editor\" data-id=\"dbbd4a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Los enfoques actuales de manejo de la HP1 tienen como objetivo aumentar la eliminaci\u00f3n de oxalato, inhibir la cristalizaci\u00f3n de oxalato o disminuir la producci\u00f3n de oxalato por parte del h\u00edgado.<sup>3,4,11<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6545417 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6545417\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/manejo\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Manejo<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4f49f3 e-flex e-con-boxed e-con e-parent\" data-id=\"f4f49f3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4e9530 elementor-hidden-tablet elementor-hidden-mobile elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b4e9530\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eeaccc0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"eeaccc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/descubrir-la-hp1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">IR A <span>DESCUBRIR LA HP1<\/span><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9b32ca e-flex e-con-boxed e-con e-parent\" data-id=\"d9b32ca\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1fc7878 e-con-full e-flex e-con e-child\" data-id=\"1fc7878\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-260f8d2 elementor-widget elementor-widget-heading\" data-id=\"260f8d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pruebas a pacientes para detectar la HP1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c10eae elementor-widget elementor-widget-text-editor\" data-id=\"1c10eae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Vea c\u00f3mo las pruebas gen\u00e9ticas desempe\u00f1an un papel importante en el diagn\u00f3stico de la HP1.<sup>3,11<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4958985 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"4958985\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/es\/pruebas-de-hp1\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Opciones de pruebas<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64116a1 e-con-full e-flex e-con e-child\" data-id=\"64116a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a4e59d5 elementor-widget elementor-widget-heading\" data-id=\"a4e59d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Obtener informaci\u00f3n actualizada<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b19f6b elementor-widget elementor-widget-text-editor\" data-id=\"9b19f6b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Registrarse para recibir informaci\u00f3n de Alnylam sobre la HP1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1f6d86 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"e1f6d86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Registrarse<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d828f46 e-flex e-con-boxed e-con e-parent\" data-id=\"d828f46\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d27d09 elementor-widget elementor-widget-text-editor\" data-id=\"6d27d09\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"footer-refs\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Referencias: 1.<\/strong> Ferraro PM, D\u2019Addessi A, Gambaro G. <em>Nephrol Dial Transplant.<\/em> 2013;28(4):811\u2013820. <strong>2.<\/strong> Hoppe B. <em>Nat Rev Nephrol.<\/em> 2012;8(8):467\u2013475. <strong>3.<\/strong> Milliner DS, Harris PC, Sas DJ, <em>et al.<\/em> Primary hyperoxaluria type 1. GeneReviews<sup>\u00ae<\/sup> [<em>Internet<\/em>]. Actualizado el 15 de agosto 2024. Consultado en enero de 2026. <a class=\"comment-text__link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/<\/a> <strong>4.<\/strong> Cochat P, Rumsby G. <em>N Engl J Med.<\/em> 2013;369(7):649\u2013658. <strong>5.<\/strong> Hoppe B, Kemper MJ. <em>Pediatr Nephrol.<\/em> 2010;25(3):403\u2013413. <strong>6.<\/strong> Jendeberg J, Geijer H, Alshamari M, <em>et al. Eur Radiol.<\/em> 2017;27(11):4775\u20134785. <strong>7.<\/strong> Carrasco A Jr, Granberg CF, Gettman MT, <em>et al. Urology.<\/em> 2015;85(3):522\u2013526. <strong>8.<\/strong> Hoppe B, Beck BB, Milliner DS. <em>Kidney Int.<\/em> 2009;75(12):1264\u20131271. <strong>9.<\/strong> Leumann E, Hoppe B. <em>J Am Soc Nephrol.<\/em> 2001;12(9):1986\u20131993. <strong>10.<\/strong> Ben-Shalom E, Frishberg Y. <em>Pediatr Nephrol.<\/em> 2015;30(10):1781\u20131791. <strong>11.<\/strong> Cochat P, Hulton SA, Acquaviva C, <em>et al. Nephrol Dial Transplant.<\/em> 2012;27(5):1729\u20131736. <strong>12.<\/strong> Groothoff JW, Metry E, Deesker L, <em>et al. Nat Rev Nephrol.<\/em> 2023;19(3):194\u2013211. <strong>13.<\/strong> Mandrile G, Rumsby G, Sciannameo V, <em>et al. Clin Kidney J.<\/em> 2025;18(7):sfaf194. <strong>14.<\/strong> Harambat J, Fargue S, Acquaviva C, <em>et al. Kidney Int.<\/em> 2010;77(5):443\u2013449. <strong>15.<\/strong> van der Hoeven SM, van Woerden CS, Groothoff JW. <em>Nephrol Dial Transplant.<\/em> 2012;27(10):3855\u20133862. <strong>16.<\/strong> Hulton SA. <em>Int J Surg.<\/em> 2016;36(Pt D):649\u2013654. <strong>17.<\/strong> Hopp K, Cogal AG, Bergstralh EJ, <em>et al. J Am Soc Nephrol.<\/em> 2015;26(10):2559\u20132570. <strong>18.<\/strong> van Woerden CS, Groothoff JW, Wanders RJA, <em>et al. Nephrol Dial Transplant.<\/em> 2003;18(2):273\u2013279. <strong>19.<\/strong> Mandrile G, van Woerden CS, Berchialla P, et al; para OxalEurope Consortium. <em>Kidney Int.<\/em> 2014;86(6):1197\u20131204. <strong>20.<\/strong> Lieske JC, Monico CG, Holmes WS, <em>et al. Am J Nephrol.<\/em> 2005;25(3):290\u2013296. <strong>21.<\/strong> Soliman NA, Nabhan MM, Abdelrahman SM, <em>et al. Nephrol Ther.<\/em> 2017;13(3):176\u2013182.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8a8bb8 elementor-widget elementor-widget-text-editor\" data-id=\"f8a8bb8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<section id=\"block-footerhomereferences\" class=\"block block-block-content block-block-contentead207f3-e885-4e6e-bd3b-f06ef2b5be1d clearfix\"><div class=\"field field--name-body field--type-text-with-summary field--label-hidden field--item\"><div class=\"container\"><div class=\"container-970\"><p class=\"references\">PH1-ESP-00172 | Enero de 2026<\/p><\/div><\/div><\/div><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La hiperoxaluria primaria de tipo 1 (HP1) es una enfermedad hereditaria progresiva rara que puede causar un deterioro de la funci\u00f3n renal. Consulte las manifestaciones de la HP1. <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-4496","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages\/4496","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/comments?post=4496"}],"version-history":[{"count":148,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages\/4496\/revisions"}],"predecessor-version":[{"id":8804,"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/pages\/4496\/revisions\/8804"}],"wp:attachment":[{"href":"https:\/\/www.thinkph1.eu\/es\/wp-json\/wp\/v2\/media?parent=4496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}