{"id":3662,"date":"2024-06-03T14:02:31","date_gmt":"2024-06-03T14:02:31","guid":{"rendered":"https:\/\/www.thinkph1.eu\/?page_id=3662"},"modified":"2026-01-13T10:02:09","modified_gmt":"2026-01-13T10:02:09","slug":"behandlung","status":"publish","type":"page","link":"https:\/\/www.thinkph1.eu\/de\/behandlung\/","title":{"rendered":"Medizinisches Management der prim\u00e4ren Hyperoxalurie Typ 1 (PH1) | Think PH1\u2122"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3662\" class=\"elementor elementor-3662 elementor-31\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f6f2230 e-flex e-con-boxed e-con e-parent\" data-id=\"f6f2230\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-216076a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-heading\" data-id=\"216076a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">BEHANDLUNG VON PH1<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6214cba elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"6214cba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die derzeitigen Behandlungsans\u00e4tze f\u00fcr PH1 zielen darauf ab, die Oxalatausscheidung zu verbessern, die Oxalatkristallisation zu hemmen oder die Oxalatproduktion in der Leber zu verrignern.<sup>1\u20133<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-070d89a e-flex e-con-boxed e-con e-parent\" data-id=\"070d89a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-981738d e-flex e-con-boxed e-con e-child\" data-id=\"981738d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-701c391 elementor-widget elementor-widget-heading\" data-id=\"701c391\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Medizinische Behandlungsm\u00f6glichkeiten<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5d53b9 elementor-widget elementor-widget-text-editor\" data-id=\"f5d53b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die medizinische Behandlung von PH1 basiert auf der Beurteilung des jeweiligen Patienten durch den Arzt oder die \u00c4rztin.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5014fa elementor-widget elementor-widget-text-editor\" data-id=\"d5014fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die derzeitigen medizinischen Managementstrategien zielen darauf ab, die Ablagerung von Calciumoxalat-Kristallen und die Steinbildung zu verringern oder die Oxalatproduktion in der Leber zu reduzieren.<sup>1\u20133<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ce0906 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"6ce0906\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"88\" height=\"88\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/water_bottles.svg\" class=\"attachment-full size-full wp-image-104\" alt=\"Water bottles Icon\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Hyperhydration<sup>2<\/sup><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea742c1 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"ea742c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Die empfohlene t\u00e4gliche Fl\u00fcssigkeitszufuhr von \u2265 2\u20133 l\/m<sup>2<\/sup> K\u00f6rperoberfl\u00e4che zielt darauf ab, die Kristallisation von Calciumoxalat im Urin zu verringern<sup>2<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fd43a4 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"5fd43a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"88\" height=\"88\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/behind-the-stone-medical-management-ph1-pyroxidine-alkali-citrate-icon.png\" class=\"attachment-full size-full wp-image-100\" alt=\"Alkali Citrate Icon\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Alkalizitrat<sup>2,3<\/sup><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15fc84d elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"15fc84d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Hemmt die Kristallisation von Calciumoxalat<sup>2,3<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c10ca36 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"c10ca36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"88\" height=\"88\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/behind-the-stone-medical-management-ph1-pyroxidine-alkali-citrate-icon.png\" class=\"attachment-full size-full wp-image-100\" alt=\"Alkali Citrate Icon\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Therapie mit hochdosiertem Pyridoxin (Vitamin B6)<sup>1,3,4<\/sup><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6547dfc elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"6547dfc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Kann als Kofaktor der AGT wirken, was bei einigen Patienten die Restaktivit\u00e4t des AGT-Enzyms erh\u00f6ht und somit die Konversionsrate von Glyoxylat zu Glycin f\u00f6rdert<sup>1,3<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Eine kleine Untergruppe von Patienten mit PH1 spricht m\u00f6glicherweise auf Vitamin B6 an<sup>1,3,4<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9727e1 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"b9727e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"88\" height=\"88\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/behind-the-stone-medical-management-ph1-pyroxidine-alkali-citrate-icon.png\" class=\"attachment-full size-full wp-image-100\" alt=\"Alkali Citrate Icon\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">RNA-Interferenz(RNAi)-Therapeutika<sup>5\u20138<\/sup><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12ff35e elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"12ff35e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Binden mit einen Komplex namens RISC (RNA induced) und dienen diesem bei der zielgerichteten Erkennung von an der Hyperoxalurie beteiligten Enzyme, deren Expression \u00fcber den RNAi-Weg unterbunden werden<sup>5,6<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Besitzt einen neuartigen Mechanismus zur Reduzierung der Oxalatproduktion, wodurch m\u00f6glicherweise der Bedarf an Transplantationen verringert werden kann<sup>7<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Die Registerdaten seit Einf\u00fchrung von RNAi zeigen einen R\u00fcckgang der Lebertransplantationen bei PH1<sup>7<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Erm\u00f6glicht eine metabolische Kontrolle, die eine alleinige Nierentransplantation in einer breiteren Bev\u00f6lkerungsgruppe unterst\u00fctzt \u2014 nicht nur bei Patienten mit Pyridoxin-responsiven <em>AGXT<\/em>-Varianten, wie bisher erfoderlich<sup>8<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39a2773 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"39a2773\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8491ea0 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"8491ea0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"88\" height=\"88\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/behind-the-stone-medical-management-ph1-dialysis-machine-icon-small.svg\" class=\"attachment-full size-full wp-image-101\" alt=\"Dialysis Machine Icon\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">DIALYSESTRATEGIEN BEI DER PH1 BEHANDLUNG<sup>1,3,9,10<\/sup><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2308f4a elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"2308f4a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Zur Senkung der Plasma-Oxalatkonzentration k\u00f6nnen bei PH1-Patienten mit eingeschr\u00e4nkter Nierenfunktion bis zu 6 H\u00e4modialysesitzungen pro Woche notwendig sein, m\u00f6glicherweise in Kombination mit einer kontinuierlichen Peritonealdialyse<sup>1,3,9,10<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Die Dialyse kann entweder als \u00dcberbr\u00fcckung bis zur Transplantation oder als Zusatztherapie zur Verringerung der Oxalatlast bei verz\u00f6gerter oder schlechter Nierenfunktion nach einer Leber-\/Nierentransplantation dienen<sup>1<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c1208e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1c1208e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84bb968 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"84bb968\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"64\" height=\"64\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/liver-icon.svg\" class=\"attachment-full size-full wp-image-102\" alt=\"Liver Icon\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">LEBER-NIEREN-TRANSPLANTATION<\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b691fea elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"b691fea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Die Lebertransplantation behebt den Defekt, der dazu f\u00fchrt, dass Glyoxylat nicht in ausreichender Menge in Glycin konvertiert wird, weshalb es zu einer Akkumulation von Glyoxylat kommt, welches alternativ in Oxalat konvertiert wird<sup>2,3<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Wenn die Nierenfunktion nachl\u00e4sst, kann eine kombinierte Nieren-Leber-Transplantation erforderlich sein<sup>1,3<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5f8700 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f5f8700\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a71ea6 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"5a71ea6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"88\" height=\"88\" src=\"https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/12\/icon-liver-and-pills.png\" class=\"attachment-full size-full wp-image-8307\" alt=\"Point de vue des patients - Ziggy\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">ALLEINIGE NIERENTRANSPLANTATION<\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d49f2f8 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"d49f2f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Die F\u00e4lle von Nierentransplantatversagen, die auf eine nicht erkannte PH1 vor der Transplantation zur\u00fcckzuf\u00fchren sind, sind zahlreich<sup>11<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Bei etwa 3 % der Nierentransplantationen kommt es innerhalb des ersten Jahres nach der Transplantation zu einem Versagen aufgrund des Verlusts der Nierenfunktion<sup>12<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-dot-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 56c110.532 0 200 89.451 200 200 0 110.532-89.451 200-200 200-110.532 0-200-89.451-200-200 0-110.532 89.451-200 200-200m0-48C119.033 8 8 119.033 8 256s111.033 248 248 248 248-111.033 248-248S392.967 8 256 8zm0 168c-44.183 0-80 35.817-80 80s35.817 80 80 80 80-35.817 80-80-35.817-80-80-80z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Eine Verringerung der Oxalateinlagerung erh\u00f6ht die Wahrscheinlichkeit eines positiven Transplantationsergebnisses bei Patienten mit PH1<sup>13,14<\/sup><\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6fdefdb e-flex e-con-boxed e-con e-parent\" data-id=\"6fdefdb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-61a454d e-con-full e-flex e-con e-child\" data-id=\"61a454d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8de0481 elementor-widget elementor-widget-heading\" data-id=\"8de0481\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DIE PH1 BEHANDLUNG KANN BELASTEND SEIN<sup>2,4<\/sup><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-59f4dbd e-con-full e-flex e-con e-child\" data-id=\"59f4dbd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e0ec18 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"5e0ec18\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/zoe-and-nathan-story-with-primary-hyperoxaluria-type-1-ph1-video-thumbnail.jpg&quot;,&quot;id&quot;:5186,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Miniaturansicht des Videos: Das Leben von Zoe und Nathan mit prim\\u00e4rer Hyperoxalurie Typ 1 (PH1)&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1040351436?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1&amp;h=e6f69614ab#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2024\/06\/zoe-and-nathan-story-with-primary-hyperoxaluria-type-1-ph1-video-thumbnail.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Miniaturansicht des Videos: Das Leben von Zoe und Nathan mit prim\u00e4rer Hyperoxalurie Typ 1 (PH1)\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8ccc3d elementor-widget elementor-widget-text-editor\" data-id=\"b8ccc3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dies ist die Geschichte von Zoe und Nathan, die an PH1 leiden \u2014 erz\u00e4hlt von ihrer Mutter Becky.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9728ac0 e-con-full e-flex e-con e-child\" data-id=\"9728ac0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-272a8f0 animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"272a8f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/PH1-ESP-0003_0PH1carer-video_Stephanie_Spanish.jpg&quot;,&quot;id&quot;:5909,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1040350640?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1&amp;h=7e25f4b16a#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/01\/PH1-ESP-0003_0PH1carer-video_Stephanie_Spanish.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd1c2ef elementor-widget elementor-widget-text-editor\" data-id=\"cd1c2ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>J\u00f6rgs Geschichte vom Leben mit PH1.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b43819c e-con-full e-flex e-con e-child\" data-id=\"b43819c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d852b57 e-con-full e-flex e-con e-child\" data-id=\"d852b57\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-151286d animated-fast elementor-invisible elementor-widget elementor-widget-video\" data-id=\"151286d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;vimeo&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/dev-thinkph1eu-wp2.pantheonsite.io\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/patient-perspective-ziggy.jpg&quot;,&quot;id&quot;:8211,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;Patient Perspective - Ziggy&quot;,&quot;source&quot;:&quot;library&quot;},&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<iframe class=\"elementor-video-iframe\" allowfullscreen allow=\"clipboard-write\" title=\"vimeo Video Player\" src=\"https:\/\/player.vimeo.com\/video\/1094033407?color&amp;autopause=0&amp;loop=0&amp;muted=0&amp;title=1&amp;portrait=1&amp;byline=1&amp;h=844df97132#t=\"><\/iframe>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/www.thinkph1.eu\/wp-content\/uploads\/2025\/02\/patient-perspective-ziggy.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video about Patient Perspective - Ziggy\" tabindex=\"0\">\n\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" height=\"121\" viewBox=\"0 0 120 121\" width=\"120\"><g fill=\"none\" fill-rule=\"evenodd\" transform=\"translate(6 .657)\"><circle cx=\"54\" cy=\"60\" fill=\"#062059\" r=\"60\"><\/circle><g transform=\"translate(25 30)\"><circle cx=\"29\" cy=\"30\" r=\"29\"><\/circle><path d=\"M44.681 29.682L18.984 47.245V13.332z\" fill=\"#FFF\"><\/path><path d=\"M56.126 28.893L12.654 59.521V1.23z\" stroke=\"#1F99D5\" stroke-linejoin=\"round\" stroke-width=\"3\"><\/path><\/g><\/g><\/svg>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de8a6c2 elementor-widget elementor-widget-text-editor\" data-id=\"de8a6c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tZiggys Mutter erz\u00e4hlt von den emotionalen Herausforderungen, vor die sie durch die PH1-Diagnose ihres Kindes gestellt wird.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b816415 e-con-full e-flex e-con e-child\" data-id=\"b816415\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fc2dffb elementor-hidden-tablet elementor-hidden-mobile elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"fc2dffb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-544e5f0 e-flex e-con-boxed e-con e-parent\" data-id=\"544e5f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a70690e elementor-align-center elementor-widget elementor-widget-button\" data-id=\"a70690e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/de\/informationsmaterial-und-unterstutzung\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">WEITER MIT <span>INFORMATIONSMATERIALIEN<br \/>UND UNTERST\u00dcTZUNG<\/span><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-49526b26 e-flex e-con-boxed e-con e-parent\" data-id=\"49526b26\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-558a6b37 e-con-full e-flex e-con e-child\" data-id=\"558a6b37\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3249e062 elementor-widget elementor-widget-heading\" data-id=\"3249e062\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Patienten auf PH1 testen<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22ede3eb elementor-widget elementor-widget-text-editor\" data-id=\"22ede3eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die wichtige Rolle von Gentests bei der Diagnose von PH1.<sup>1,3<\/sup><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c8c958e elementor-align-center elementor-widget elementor-widget-button\" data-id=\"5c8c958e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/de\/auf-ph1-testen\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Testoptionen<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1eb70ff1 e-con-full e-flex e-con e-child\" data-id=\"1eb70ff1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-69fd5295 elementor-widget elementor-widget-heading\" data-id=\"69fd5295\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Updates erhalten<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d92e4b9 elementor-widget elementor-widget-text-editor\" data-id=\"2d92e4b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Melden Sie sich an, um Informationen von Alnylam \u00fcber PH1 zu erhalten.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6a7816ea elementor-align-center elementor-widget elementor-widget-global elementor-global-3470 elementor-global-493 elementor-widget-button\" data-id=\"6a7816ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.alnylamconnect.eu\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Anmelden<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4850b1b e-flex e-con-boxed e-con e-parent\" data-id=\"4850b1b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3d3c4f4 elementor-widget elementor-widget-text-editor\" data-id=\"3d3c4f4\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"footer-refs\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Literatur: 1.<\/strong> Milliner DS, Harris PC, Sas DJ, <em>et al.<\/em> Primary hyperoxaluria type 1. GeneReviews<sup>\u00ae<\/sup> [<em>Internet<\/em>]. Aktualisiert am 15.08.2024. Zugriff: Januar 2026. <a class=\"comment-text__link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1283\/<\/a> <strong>2.<\/strong> Cochat P, Rumsby G. <em>N Engl J Med.<\/em> 2013;369(7):649\u2013658. <strong>3.<\/strong> Cochat P, Hulton SA, Acquaviva C, <em>et al. Nephrol Dial Transplant.<\/em> 2012;27(5):1729\u20131736. <strong>4.<\/strong> Hoyer-Kuhn H, Kohbrok S, Volland R, <em>et al. Clin J Am Soc Nephrol.<\/em> 2014;9(3):468\u2013477. <strong>5.<\/strong> Le Dudal M, Huguet L, Perez J, <em>et al. J Clin Invest.<\/em> 2019;129(6):2571\u20132577. <strong>6.<\/strong> Lai C, Pursell N, Gierut J, <em>et al. Mol Ther.<\/em> 2018;26(8):1983\u20131995. <strong>7.<\/strong> Tan E, Ahimsadasan N, Than Hlaing NK, <em>et al. Am J Transplant.<\/em> 2025;25(12):2611\u20132620. <strong>8.<\/strong> Moretti MI, Leporati M, Mazzucchelli R, <em>et al. Case Rep Nephrol Dial.<\/em> 2025;15(1):141\u2013149. <strong>9.<\/strong> Cochat P, Fargue S, Harambat J. <em>Curr Opin Organ Transplant.<\/em> 2010;15(5):590\u2013593. <strong>10.<\/strong> Plumb TJ, Swee ML, Filaus JA. <em>Am J Kidney Dis.<\/em> 2013;62(6):1155\u20131159. <strong>11.<\/strong> Cai Z, Ding M, Chen R, <em>et al. BMC Nephrol.<\/em> 2021;22(1):393. <strong>12.<\/strong> Helanter\u00e4 I, R\u00e4ih\u00e4 J, Finne P, Lempinen M. <em>Transpl Int.<\/em> 2018;31(8):880\u2013886. <strong>13.<\/strong> Somers MJ, Devresse A, Willey R, <em>et al.<\/em> Pr\u00e4sentation anl\u00e4sslich: National Kidney Foundation (NKF) Spring Clinical Meeting; 10.\u201313. April 2025; Boston, MA. <strong>14.<\/strong> Devresse A, Cochat P, Godefroid N, <em>et al. Kidney Int Rep.<\/em> 2020;5(12):2136\u20132145.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b76702a elementor-widget elementor-widget-text-editor\" data-id=\"b76702a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>PH1-DEU-00129 | Januar 2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Erfahren Sie mehr \u00fcber medizinische Managementoptionen der prim\u00e4ren Hyperoxalurie Typ 1 (PH1), wie z. B. Hyperhydratation, hochdosierte Pyridoxin-Therapie (Vitamin B6) und Dialyse.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-3662","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/pages\/3662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/comments?post=3662"}],"version-history":[{"count":133,"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/pages\/3662\/revisions"}],"predecessor-version":[{"id":8718,"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/pages\/3662\/revisions\/8718"}],"wp:attachment":[{"href":"https:\/\/www.thinkph1.eu\/de\/wp-json\/wp\/v2\/media?parent=3662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}